Medical Center District Travel Guide

San Antonio

River walk in San Antonio
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
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Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is Rp1.378.318 per night from 28 May to 29 May
Rp1.378.318
Rp1.629.297 total
28 May - 29 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,312 reviews)
I am writing to formally raise a complaint regarding my recent stay at your property. I originally booked a two-night stay for $263; however, I was ultimately charged $362. When I returned to the front desk for clarification, I was told there was a $20 parking fee. This fee was not disclosed during ...

Reviewed on 27 Apr 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is Rp1.889.160 per night from 2 May to 3 May
Rp1.889.160
Rp2.244.873 total
2 May - 3 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,041 reviews)
The room has small stains in the mirror and walls

Reviewed on 27 Apr 2026

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is Rp1.596.267 per night from 3 May to 4 May
Rp1.596.267
Rp1.886.932 total
3 May - 4 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.8/10 Excellent! (1,003 reviews)
It was good ! The mattress was a little soft! But everything else was good!

Reviewed on 14 Apr 2026

Courtyard by Marriott Medical Center San Antonio
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
The price is Rp2.342.972 per night from 10 May to 11 May
Rp2.342.972
Rp2.769.602 total
10 May - 11 May
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and 2 hot tubs. Our guests praise the breakfast and the pool in their reviews. ...
9.4/10 Exceptional! (4,543 reviews)
Very friendly staff, breakfast is great and the location is wonderful, we really enjoyed our time there.

Reviewed on 27 Apr 2026

Drury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is Rp1.535.104 per night from 10 May to 11 May
Rp1.535.104
Rp1.814.558 total
10 May - 11 May
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,448 reviews)
The location was perfect for the trip. We wanted to be close to the river and the parking was 40$ per day but had in and out privileges. Now the room was pretty much falling apart from decor hanging halfway out the way to the tub leaking and the toilet rocking when you sit on it. The patio door did ...

Reviewed on 26 Apr 2026

Riverwalk Plaza
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
The price is Rp1.666.906 per night from 10 May to 11 May
Rp1.666.906
Rp1.970.481 total
10 May - 11 May
includes taxes & fees
Stay at this historic hotel in San Antonio. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the pool and the bar in their reviews. ...
8.8/10 Excellent! (3,943 reviews)
The room was spacious with a great patio.

Reviewed on 27 Apr 2026

Menger Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

SanAntonio_UniversityofTexasSanAntonio_502634_03

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

Northwest Side
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Shearer Hills - Ridgeview

While visiting Shearer Hills - Ridgeview, you might make a stop by sights like North Star Mall and San Pedro Driving Range & Par 3 Course.

Shearer Hills - Ridgeview
River Walk in San Antonio, Texas

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or The DoSeum while you're exploring the area.

Midtown
Historic architecture Spanish San Antonio Texas Mission San Jose on a cloudy day

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
Tobin Hill

Tobin Hill

Tobin Hill might not have many top sights, but San Antonio Zoo and Aquarium and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
Dallas Skyline Reflection on Trinity River During Sunset, Dallas, Texas.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown


Medical Center District Travel Guide