Medical Center District Travel Guide

San Antonio

Photo by Linda Cronan

Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is Rp1.480.829 per night from 11 Dec to 12 Dec
Rp1.480.829
Rp1.750.313 total
11 Dec - 12 Dec
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,109 reviews)
Clean room , everything looks fresh. Decent morning breakfast.

Reviewed on 8 Dec 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is Rp1.484.164 per night from 14 Dec to 15 Dec
Rp1.484.164
Rp1.763.754 total
14 Dec - 15 Dec
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.4/10 Very Good! (1,001 reviews)
Overall great. However, phone didn’t work. No conditioner in bottle. half roll of toilet paper to use and had to use it sparingly. Don’t care where the AC is stationed. Little things that didn’t make it so bad at all. Thank you.

Reviewed on 3 Dec 2025

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
The price is Rp1.484.164 per night from 17 Dec to 18 Dec
Rp1.484.164
Rp1.754.415 total
17 Dec - 18 Dec
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
8.6/10 Excellent! (1,000 reviews)
Every time we’ve stayed here, the staff is always friendly and helpful.

Reviewed on 7 Dec 2025

Courtyard by Marriott Medical Center San Antonio
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is Rp1.726.800 per night from 14 Dec to 15 Dec
Rp1.726.800
Rp2.517.576 total
14 Dec - 15 Dec
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
9.4/10 Exceptional! (2,223 reviews)
Stayed here for an unexpected trip and everything was amazing. I have stayed at several hotels for business, pleasure, etc from 1 star to 5 stars and I can’t speak highly enough about his hotel. The Hotel Valencia Riverwalk truly impressed me from every point of contact throughout my stay. The entire ...

Reviewed on 8 Dec 2025

Hotel Valencia Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the ...
8/10 Very Good! (6,140 reviews)
The hotel was excellent. Staff is very friendly and helpful.

Reviewed on 6 Dec 2025

Riverwalk Plaza
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
The price is Rp1.261.539 per night from 4 Jan to 5 Jan
Rp1.261.539
Rp2.179.972 total
4 Jan - 5 Jan 2026
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the helpful staff in their reviews. ...
8.8/10 Excellent! (1,265 reviews)
Incredible location, beautiful room, loved all of it!

Reviewed on 5 Dec 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

Northwest Side
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Shearer Hills - Ridgeview

While visiting Shearer Hills - Ridgeview, you might make a stop by sights like North Star Mall and San Pedro Driving Range & Par 3 Course.

Shearer Hills - Ridgeview
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Midtown

Unique features of Midtown include the river views and bars. Make a stop by The DoSeum or San Antonio Zoo and Aquarium while you're exploring the area.

Midtown
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La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
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Tobin Hill

Tobin Hill might not have many top sights, but San Antonio Museum of Art and Historic Brackenridge Golf Course are two attractions nearby that you can check out.

Tobin Hill
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Uptown

If you're spending some time in Uptown, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

Uptown


Medical Center District Travel Guide