The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,412 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,046 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,001 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,139 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,518 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

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Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A large, abstract sculpture with a flowing design, set against a dramatic sky.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

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A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

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A riverside walkway with colorful umbrellas, a stone bridge, and a red sculpture.

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or Historic Brackenridge Golf Course while you're exploring the area.

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Top Medical Center District Hotel Reviews

JW Marriott San Antonio Hill Country Resort & Spa

10/10 Excellent

"The hotel is amazing!"

Drury Inn & Suites San Antonio Northwest Medical Center

8/10 Good

"Check in & check out was a breeze. The buffet breakfast and the happy hour reception were amazing and delicious. The vent did not work in the bathroom, and there was a lot of dust buildup in the bathroom vent (visible to eye). No safe in room, not sure if any rooms have a safe. The room was otherwise very comfortable & having the large refrigerator was great. The property inside was clean, but the parking lot had a lot of trash. Not very appealing when coming/going. Lastly, the giant A/C units outside are very loud on the one side of the hotel. While obviously needed, just know that they are loud."

Hotel Contessa

8/10 Good

"The hotel is in a great location, no doubt about it. This was my second stay here. The entrance was pretty dirty, but once you get inside, the property is nice. Check-in was slow, and the staff didn’t seem to be in the best mood. They came across as a little rude. However, the room was clean, spacious, and comfortable. It’s also very easy to get to the River Walk from the hotel. One thing to keep in mind is the valet parking. At $60 per night, I found it to be very expensive, especially since there’s parking available directly across the street for only $24. Overall, despite the check-in experience, I would consider staying here again because of the convenient location, clean and spacious rooms, and easy access to the River Walk."

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and Drury Inn & Suites San Antonio Northwest Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 130 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

USAA Corporate Office Headquarters, The San Antonio Art Institute and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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Our top choices for Medical Center District hotels

1. Courtyard by Marriott Medical Center San Antonio

2. Drury Inn & Suites San Antonio Northwest Medical Center

3. Park Inn by Radisson

4. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

5. Studio 6 Extended Stay - San Antonio, TX - Medical Center

6. OYO Inn & Suites Medical Center San Antonio

7. Fairfield Inn & Suites by Marriott San Antonio Medical Center

8. San Antonio Marriott Northwest Medical Center

9. Motel 6 San Antonio, TX - Northwest Medical Center

10. Atria Inn & Suites

11. Studio 6 San Antonio, Tx - Northwest Medical Center

12. Flex Studios

13. Drury Plaza Hotel San Antonio Airport

14. La Quinta Inn & Suites by Wyndham San Antonio Airport

15. Wyndham Garden San Antonio Airport

16. Holiday Inn Express San Antonio-Airport by IHG

17. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

18. Drury Plaza Hotel San Antonio North Stone Oak

19. Days Inn by Wyndham San Antonio Airport

20. Hyatt Place San Antonio-Northwest/Medical Center

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Far West Side

Uptown

La Cantera District

Midtown

Top Medical Center District Hotel Reviews

JW Marriott San Antonio Hill Country Resort & Spa

Frequently asked questions

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