The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices

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Compare popular hotels in Medical Center District

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	3.0 star property	9.2 Wonderful 1,393 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	3.0 star property	9.0 Wonderful 1,041 reviews	View
Courtyard by Marriott Medical Center San Antonio	3.0 star property	8.8 Excellent 1,003 reviews	View
San Antonio Marriott Northwest Medical Center	3.5 star property	8.6 Excellent 1,134 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	3.0 star property	8.4 Very good 3,533 reviews	View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.

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Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

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A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

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A large, abstract sculpture with a flowing design, set against a dramatic sky.

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

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A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

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A riverside walkway with colorful umbrellas, a stone bridge, and a red sculpture.

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or Historic Brackenridge Golf Course while you're exploring the area.

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Top Medical Center District Hotel Reviews

Signia by Hilton La Cantera Resort & Spa

10/10 Excellent

"Friendly and helpful staff. Feels like paradise in the Hill Country. Food and beverages everywhere we went were outstanding. Will be back!"

Menger Hotel

8/10 Good

"I have stayed here multiple times. I love to stay here because of the history. Being the oldest hotel west of the Mississippi, it is probably not the nicest hotel in downtown, but to me it is the coolest. The location is super nice once you get there. Getting to the drop off area valet parking is always difficult and I forget how to get to it every time I stay. Easy walking distance to the Alamo, the mall, the riverwalk and tons of restaurants and bars. You must go to the bar at the hotel just to say you were in the bar where Teddy Rosevelt recruited the rough riders. We have stayed in the original section and have experienced “ghost” or heard things like kids laughing and playing in the hall @ 4am. We will stay here again."

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

8/10 Good

"This was a decent stay. The hotel is well kept, the breakfast is good, and the staff are very polite. A huge thank you to Olga in the lounge, who was so friendly and welcoming! My only issue was that my room had stained bed sheets when I arrived. I told the front desk, and they quickly brought up clean ones to fix the problem. Good service overall!"

Frequently asked questions

What is Medical Center District like?

Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Are you looking for Medical Center District travel tips? Make sure that you visit USAA Corporate Office Headquarters and Cinemark San Antonio 16 while you're in the neighbourhood.

What's a favourite hotel to stay in Medical Center District?

Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Courtyard by Marriott Medical Center San Antonio and San Antonio Marriott Northwest Medical Center.

How many hotels will I be able to find in Medical Center District?

Expedia has 129 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.

If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.

What can I see and do in this San Antonio neighbourhood?

A few attractions you might want to check out while you're in Medical Center District are USAA Corporate Office Headquarters and Cinemark San Antonio 16. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.

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Our top choices for Medical Center District hotels

1. Courtyard by Marriott Medical Center San Antonio

2. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3. Park Inn by Radisson

4. Drury Inn & Suites San Antonio Northwest Medical Center

5. OYO Inn & Suites Medical Center San Antonio

6. Fairfield Inn & Suites by Marriott San Antonio Medical Center

7. Studio 6 Extended Stay - San Antonio, TX - Medical Center

8. San Antonio Marriott Northwest Medical Center

9. Atria Inn & Suites

10. Motel 6 San Antonio, TX - Northwest Medical Center

11. Studio 6 San Antonio, Tx - Northwest Medical Center

12. Flex Studios

13. Drury Plaza Hotel San Antonio Airport

14. La Quinta Inn & Suites by Wyndham San Antonio Airport

15. Drury Plaza Hotel San Antonio North Stone Oak

16. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

17. Hyatt Place San Antonio-Northwest/Medical Center

18. Wyndham Garden San Antonio Airport

19. Days Inn by Wyndham San Antonio Airport

20. Holiday Inn Express San Antonio-Airport by IHG

Compare popular hotels in Medical Center District

Where to stay in Medical Center District

Downtown San Antonio

Far West Side

Uptown

La Cantera District

Midtown

Top Medical Center District Hotel Reviews

Signia by Hilton La Cantera Resort & Spa

Frequently asked questions

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