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Check prices for these dates

This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

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Our top choices for Medical Center District hotels

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

1. Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,000 reviews)
"Amazing stay!!!!"
United States
Erik
The price is Rp1.587.584
Rp1.876.667 total
includes taxes & fees
2 Oct - 3 Oct
Courtyard by Marriott Medical Center San Antonio
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

2. Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,463 reviews)
"Nice hotel"
United States
Clifton T
The price is Rp1.603.442
Rp1.895.414 total
includes taxes & fees
1 Oct - 2 Oct
Drury Inn & Suites San Antonio Northwest Medical Center
A modern kitchen with a large window, wooden counter, and two bar stools.

3. Park Inn by Radisson, Medical Center

Park Inn by Radisson, Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (1,001 reviews)
"My room was clean, the staff were very helpful and kind."
United States
Joanne
The price is Rp1.196.479
Rp1.396.890 total
includes taxes & fees
23 Oct - 24 Oct
Park Inn by Radisson, Medical Center
A self-service snack and drink vending area with multiple shelves stocked with various products.

4. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very good, (3,679 reviews)
"We had a great stay"
United States
Maria
The price is Rp1.582.238
Rp1.870.347 total
includes taxes & fees
27 Sept - 28 Sept
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

5. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,082 reviews)
"Super clean, staff was really helpful and breakfast has a good variety"
United States
Paola
The price is Rp1.704.826
Rp1.990.385 total
includes taxes & fees
29 Sept - 30 Sept
Fairfield Inn & Suites by Marriott San Antonio Medical Center
A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

6. OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (248 reviews)
"great place to stay close to the hospital. Would stay there again"
United States
Melanie
The price is Rp904.263
Rp1.146.153 total
includes taxes & fees
8 Oct - 9 Oct
OYO Inn & Suites Medical Center San Antonio
A spacious lobby with a central staircase, seating area, and large windows.

7. San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,164 reviews)
"Great hotel"
United States
Mario
The price is Rp1.531.947
Rp1.820.343 total
includes taxes & fees
25 Oct - 26 Oct
San Antonio Marriott Northwest Medical Center
A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

8. Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (315 reviews)
"Amazing comfortable and affordable"
United States
José
The price is Rp1.028.989
Rp1.201.344 total
includes taxes & fees
27 Sept - 28 Sept
Atria Inn & Suites
A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

9. Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (373 reviews)
"It's a good place to stay I"
United States
Ruben
The price is Rp835.842
Rp975.845 total
includes taxes & fees
4 Oct - 5 Oct
Studio 6 San Antonio, Tx - Northwest Medical Center
A modern bedroom with a large bed, bedside tables, a desk, and a chair.

10. Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (999 reviews)
"front desk reps very friendly and helpful"
United States
Rachel
The price is Rp801.810
Rp1.019.083 total
includes taxes & fees
10 Oct - 11 Oct
Motel 6 San Antonio, TX - Northwest Medical Center
A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

11. Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.2 out of 10, (573 reviews)
"Yes I would stay again"
United States
Jasper
The price is Rp783.992
Rp926.749 total
includes taxes & fees
4 Oct - 5 Oct
Flex Studios
A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

12. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (994 reviews)
"Good for a short stay traveling through the SA area."
United States
Jerron
Studio 6 Extended Stay - San Antonio, TX - Medical Center
A modern lobby with a sofa, patterned chairs, a central ottoman, and a chandelier.

13. Drury Plaza Hotel San Antonio Airport

Drury Plaza Hotel San Antonio Airport
3.0 star property
9 km from Medical Center District
9.4 out of 10, Exceptional, (2,296 reviews)
"Very close to the airport, food nearby"
United States
Jay
The price is Rp2.031.074
Rp2.400.911 total
includes taxes & fees
28 Sept - 29 Sept
Drury Plaza Hotel San Antonio Airport
A modern kitchen with a central island, built-in appliances, and a coffee station.

14. Wyndham Garden San Antonio Airport

Wyndham Garden San Antonio Airport
3.0 star property
Uptown Central, 9.2 km from Medical Center District
8.6 out of 10, Excellent, (1,939 reviews)
"Location is good and close to airport"
United States
SWAROOP JADHAV
The price is Rp1.517.203
Rp1.793.382 total
includes taxes & fees
27 Sept - 28 Sept
Wyndham Garden San Antonio Airport
A spacious living area with a dark blue sofa, four grey armchairs, and three metallic coffee tables.

15. La Quinta Inn & Suites by Wyndham San Antonio Airport

La Quinta Inn & Suites by Wyndham San Antonio Airport
3.0 star property
9.3 km from Medical Center District
7.8 out of 10, Good, (2,709 reviews)
"Exceptional customer service, professional and d knowledgeable staff, clean spacious rooms, and comfortable beds."
United States
Gonzalo
The price is Rp1.411.186
Rp1.668.121 total
includes taxes & fees
28 Sept - 29 Sept
La Quinta Inn & Suites by Wyndham San Antonio Airport
A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

16. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
2.5 star property
Uptown Central, 9.3 km from Medical Center District
9.0 out of 10, Wonderful, (2,237 reviews)
"Great stay"
United States
Aaron
The price is Rp1.425.262
Rp1.684.870 total
includes taxes & fees
27 Sept - 28 Sept
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham
A modern bar area with a central island, bar stools, and a kitchen counter with appliances.

17. Hyatt Place San Antonio-Northwest/Medical Center

Hyatt Place San Antonio-Northwest/Medical Center
3.0 star property
3.7 km from Medical Center District
8.4 out of 10, Very good, (1,051 reviews)
"Good location, clean, very helpful staff and good breakfast"
United States
Erica
The price is Rp1.657.074
Rp1.980.549 total
includes taxes & fees
1 Oct - 2 Oct
Hyatt Place San Antonio-Northwest/Medical Center
A Holiday Inn Express reception desk with a modern design, featuring a large illuminated sign, a reception area, and a potted plant.

18. Holiday Inn Express San Antonio-Airport by IHG

Holiday Inn Express San Antonio-Airport by IHG
2.5 star property
8.9 km from Medical Center District
9.4 out of 10, Exceptional, (1,003 reviews)
"Good place to stay, staff was really attentive to our needs!"
United States
Liz
The price is Rp1.799.618
Rp2.127.311 total
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Express San Antonio-Airport by IHG
A spacious lobby with a modern design, featuring a large seating area with sofas and armchairs, a patterned rug, and a reception desk.

19. Comfort Inn and Suites Near Medical Center

Comfort Inn and Suites Near Medical Center
2.5 star property
4.6 km from Medical Center District
7.2 out of 10, Good, (2,276 reviews)
"great service and free parking"
United States
Kalkidan
The price is Rp995.848
Rp1.233.925 total
includes taxes & fees
18 Oct - 19 Oct
Comfort Inn and Suites Near Medical Center
A hotel pool area with lounge chairs and a building with large windows in the background.

20. The Westin San Antonio North

The Westin San Antonio North
4.0 star property
3.4 km from Medical Center District
8.4 out of 10, Very good, (1,632 reviews)
"Safe and secure location, nice hotel. It's on my list now."
United States
Jack
The price is Rp1.787.145
Rp2.141.609 total
includes taxes & fees
2 Oct - 3 Oct
The Westin San Antonio North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.
Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
9.2
Wonderful
1,463 reviews
View
A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,082 reviews
View
A modern bar area with wooden bar counters, black bar stools, and pendant lighting.
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,000 reviews
View
A spacious lobby with a central staircase, seating area, and large windows.
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,164 reviews
View
A self-service snack and drink vending area with multiple shelves stocked with various products.
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very good
3,679 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most.
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

A riverside walkway with colorful umbrellas, a stone bridge, and historic buildings.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A riverside walkway adorned with colorful umbrellas and festive lights.

Uptown Central

If you're spending some time in Uptown Central, Marion Koogler McNay Art Museum and Alamo Quarry Market are top sights worth seeing.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Crystal Ice Palace are top sights worth seeing.

A historic stone building with a large wooden door, arched windows, and ornate columns.

Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista at Stone Oak while you're in town.

Top Medical Center District Hotel Reviews

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

8/10 Good
"Very affordable"
Daniel 1-night trip
Posted 8 hours ago
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

Frequently asked questions

What is Medical Center District like?
Travellers are sure to enjoy a stay in San Antonio's Medical Center District neighbourhood. Consider a visit to Cinemark San Antonio 16 as part of your Medical Center District travel plans.
What's a favourite hotel to stay in Medical Center District?
Based on our traveller data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include Drury Inn & Suites San Antonio Northwest Medical Center and Courtyard by Marriott Medical Center San Antonio.
How many hotels will I be able to find in Medical Center District?
Expedia has 124 hotels and other accommodation options in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Medical Center District.
What can I see and do in this San Antonio neighbourhood?
Cinemark San Antonio 16 is an attraction you might want to check out while you're in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.