The Best Hotels in Santa Lucia, Syracuse - 2026 Updated Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Compare popular hotels in Santa Lucia

Property	Property class	Guest rating
Calafatari B&B	3.0 star property	10.0 Exceptional 13 reviews	View
Giuggiulena Villa	3.0 star property	10.0 Exceptional 129 reviews	View
Caportigia Boutique Hotel	5.0 star property	9.4 Exceptional 283 reviews	View
Hotel Palazzo Cavalieri	4.0 star property	9.0 Wonderful 42 reviews	View
Nostos rooms & Apartments	3.0 star property	9.0 Wonderful 282 reviews	View

Where to stay in Santa Lucia

Find the best Santa Lucia areas for the activities you enjoy most.

A historic waterfront with a stone bridge, illuminated buildings, and a calm water body.

Ortigia

Ortigia is popular for its seaside views, and if you're looking for more to see and do, you might think about a trip to Cathedral of Syracuse or Piazza del Duomo.

See properties

Neapolis

While visiting Neapolis, you might make a stop by sights like Roman Amphitheatre of Syracuse and Archaeological Park of Neapolis.

See properties

Grottasanta

Grottasanta is noteworthy for its historical sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.

See properties

Acradina

You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.

See properties

Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe

Tiche

Gardens and restaurants are notable features of Tiche. You might consider stopping by Ionian Sea while you're exploring the neighbourhood.

See properties

Top Santa Lucia Hotel Reviews

Siracusa Resort Musciara

10/10 Excellent

"We loved this property run by an incredible and warm mother / daughter duo. It’s one of a kind. Absolutely stunning and immaculate. They made our family feel like family. I cannot say enough!!! We will be back for sure!!"

Caportigia Boutique Hotel

10/10 Excellent

"Valentina was so very lovely and helpful. She was very informative as well. The property is very beautiful and a great location. My only criticism is the sound the doors make when you unlock the room door. It’s a very load electronic buzzing sound. Late at night you can hear other people coming in late because of it. The room we were upgraded to was very beautiful and much appreciated. The bathroom walls and ceiling looked like they were just patched up but not painted. The rooftop is beautiful and has stunning views."

Palazzo Artemide - VRetreats, SLH Collection

10/10 Excellent

"Beautiful hotel in central Ortigia. The room was so comfortable and the view was gorgeous to the streets below. The staff were incredibly helpful. And the breakfast was fantastic on the outdoor terrace. We wouldn’t hesitate to recommend staying here. We loved our time in the city and st this hotel."

Algila' Ortigia Charme Hotel

10/10 Excellent

"We were encouraged by a tour guide to book a multi-star resort hotel in the Center of Siracusa. But, our research persuaded us that a boutique hotel on the Island of Ortigia was more in line with our standards and preferences. The Algila Ortigia Charme Hotel both met and exceeded our expectations. Everything, including the Center of Siracusa was within walking distance. The morning breakfast was convenient and ample. The bar was a nice place for a nightcap and the whisky selection was excellent. Our Junior Suite was very comfortable with quiet and great air conditioning. Our only regret was that we did not have more time to enjoy the terrace and views that were connected to our room."

Eureka Palace Hotel Spa Resort

8/10 Good

"The room was spacious, very clean, balcony was huge with a view over the front of the hotel. The staff were very friendly. Particularly the resteraunt staff. Veronica was very helpful with the menu and very courteous. The food was excellent both for breakfast & Dinner. A minor observation was that the power sockets in the room required a different adapter, not supplied , we had to loan from reception. Also there was no tea making facilities in the room , we had to ask for this from reception, and inconvenience rather than a complaint, we should of been told of this on checking in. The Bars both inside & by the pool were not operational., throughout our stay. Overall it was a very nice hotel oh and the pools were very good & well maintained. Anyone who may be planning to go there should be aware that it's a remote location, no local transport whatsoever. Imperative that you need a car. There is no shuttle bus available. A taxi cost £60 to the town. I don't think I've been over critical, but I hope this review helps you as a potential visitor."

Frequently asked questions

What is Santa Lucia like?

Santa Lucia is a neighbourhood that people enjoy for its interesting historical sites. Are you looking for Santa Lucia travel tips? Make sure that you visit Porto Piccolo and Ionian Sea while you're in the neighbourhood.

Where is the best hotel for a stay in Santa Lucia?

Based on our traveller data, Grande Albergo Alfeo is one of the top choices for your stay in Santa Lucia. This hotel is a short 9-minute walk from Lungomare di Ortigia, and it offers free breakfast and a restaurant. Other good choices for your stay in the area include Nostos rooms & Apartments and Caportigia Boutique Hotel.

How many hotels will I find in Santa Lucia?

Expedia has 312 hotels and other accommodation options in Santa Lucia to choose from, making this an ideal home base for exploring the greater Syracuse area.

If I need to cancel my hotel reservation in Santa Lucia, will I receive a refund?

Yes! You'll find that most hotel room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to review the best options available in Santa Lucia.

What are the top things to see and do in Santa Lucia?

Landmarks in Santa Lucia that you won't want to miss include Syracuse Forum Ruins and Santa Lucia Bridge. Porto Piccolo and Ionian Sea are some other stops worth a visit in the neighbourhood. A few places to visit in the area around Santa Lucia include Piazza Santa Lucia, Santa Lucia al Sepolcro Basilica and Madonna delle Lacrime. When you're sightseeing in Syracuse, Papyrus Museum and Museo Archeologico Regionale Paolo Orsi are also worth a stop.

Explore a world of travel with Expedia

More ways to book

Book Hotels in Santa Lucia on Expedia.it

Search Hotels in Santa Lucia, Syracuse

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Santa Lucia hotels

B&B IL MORO

Melody rooms

Nostos rooms & Apartments

Hotel Palazzo Cavalieri

B&B Nike

Le Camere Luxsury Rooms

Caportigia Boutique Hotel

Isonzo Suites

B&B L'INFIORESCENZA

Gymnasium

Hotel Mediterraneo

Piccolo Hotel Casa Mia

Fortaleza Charme House

B&B Siracusa

AmaCasa Siracusa

Eos Elegant Apartment & Suites

San Nicola Rooms Siracusa

Eos Serenity Suites

Grande Albergo Alfeo

Lakkios

Compare popular hotels in Santa Lucia

Where to stay in Santa Lucia

Ortigia

Neapolis

Grottasanta

Acradina

Tiche

Top Santa Lucia Hotel Reviews

Siracusa Resort Musciara

Frequently asked questions

Explore a world of travel with Expedia