Otay Mesa Hotel Guide - 5 Stars Hotels in Otay Mesa, San Diego

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Check availability on Otay Mesa 5 Star Hotels

Tonight
4 Dec - 5 Dec
Tomorrow
5 Dec - 6 Dec
This weekend
5 Dec - 7 Dec
Next weekend
12 Dec - 14 Dec

Top Otay Mesa 5 Star Hotels

3 restaurants, breakfast, lunch, dinner served; seafood
Pendry San Diego

Pendry San Diego

5.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1001)
"Stunning hotel, delicious restaurants, energizing location and beautiful time! Can’t wait to come back! "
United States
Lisa K
The price is Rp4.240.140
Rp5.789.533 total
includes taxes & fees
24 Dec - 25 Dec
Pendry San Diego
Cocktail bar
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

5.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1002)
"I loved my stay here ! I would definitely stay here again . The staff were pleasant and welcoming. The amenities were great ! The only complaint I have is I wish parking was included in our stay if you’re staying at the hotel as a guest "
United States
Vanessa
The price is Rp4.723.183
Rp5.476.295 total
includes taxes & fees
5 Jan - 6 Jan 2026
The US Grant, a Luxury Collection Hotel, San Diego
Terrace/patio
Shore House at The Del, LXR Hotels & Resorts

Shore House at The Del, LXR Hotels & Resorts

5.0 star property
Historic Downtown Coronado
9.2 out of 10, Wonderful, (112)
"What a beautiful place. We had the best room with an incredible view of the ocean. The staff was very friendly and helpful. We will definitely return."
United States
Charles
The price is Rp9.311.680
Rp11.167.366 total
includes taxes & fees
11 Dec - 12 Dec
Shore House at The Del, LXR Hotels & Resorts
Exterior
Beach Village at The Del, LXR Hotels & Resorts

Beach Village at The Del, LXR Hotels & Resorts

5.0 star property
Historic Downtown Coronado
9.2 out of 10, Wonderful, (120)
"Best place I’ve ever stayed "
United States
Kevin
The price is Rp11.972.160
Rp14.024.122 total
includes taxes & fees
17 Dec - 18 Dec
Beach Village at The Del, LXR Hotels & Resorts
Terrace/patio
The Bower Coronado

The Bower Coronado

5.0 star property
Historic Downtown Coronado
9.2 out of 10, Wonderful, (147)
"Wonderful service. Great location. Beautiful design. "
United States
Kelly
The price is Rp3.427.031
Rp4.601.134 total
includes taxes & fees
7 Dec - 8 Dec
The Bower Coronado
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Otay Mesa.
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

1500 Orange Ave Coronado CA
The price is Rp5.639.386 per night from 5 Jan to 6 Jan
Rp5.639.386
Rp7.183.902 total
5 Jan - 6 Jan 2026
includes taxes & fees
8.4/10 Very Good! (1,022 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Otay Mesa?
How much you pay for a 5-star hotel in Otay Mesa can vary according to when you want to travel and how long you plan to stay, among a number of factors. Use our price per night filter and other search tools to score the best deal on a luxurious stay.

  • Search for the lowest price per night from Rp2.100.143

What makes a hotel 5 stars in Otay Mesa?
From gourmet dining venues and 24-hour fitness centres to swimming pools and deluxe bedding, the 5-star experience in Otay Mesa is all about luxury and comfort. But it calls for more than just upscale perks to receive a 5-star rating. Stays also have to offer remarkable guest services like in-room beauty treatments, on-site laundry and concierge services.
Are there any 5-star all-inclusive resorts in Otay Mesa?
Use our filters to find a luxury getaway in Otay Mesa where most of what you need is included in the price. Next, refine your results for resorts that have a rating of 5 stars and are described as "All inclusive." The main thing on the schedule at these stays? Relaxation and indulgence.

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