Otay Mesa Holidays

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

3 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is Rp7.070.976 per night from 3 Feb to 4 Feb
Rp7.070.976
Rp9.006.075 total
3 Feb - 4 Feb
includes taxes & fees
8.8/10 Excellent! (3,253 reviews)
Great location clean place and very friendly staff

Reviewed on 20 Jan 2026

Hard Rock Hotel San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
The price is Rp1.977.001 per night from 22 Feb to 23 Feb
Rp1.977.001
Rp2.292.232 total
22 Feb - 23 Feb
includes taxes & fees
8.8/10 Excellent! (918 reviews)
Very friendly and helpful staff, safe location. Bathrooms were clean, rooms were comfortable. Wifi wasn’t high speed or anything, but I had no issues with it.

Reviewed on 17 Jan 2026

The DEXTRO Little Italy, BW Premier Collection
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
The price is Rp3.362.304 per night from 30 Jan to 31 Jan
Rp3.362.304
Rp4.608.225 total
30 Jan - 31 Jan
includes taxes & fees
8.2/10 Very Good! (3,248 reviews)
I love that place !!! I will definitely come back again.

Reviewed on 18 Jan 2026

Sheraton San Diego Resort
See all 4,905 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as , a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

4.5/5(47 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
USS Midway Museum which includes military items

USS Midway Museum

4.5/5(51 reviews)

Experience the thrills and hardships of Navy life at this waterfront museum which has become a San Diego landmark.

USS Midway Museum

Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Rp1.740.767
per adult
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
Tijuana Urban Art Walk from San Diego

Tijuana Urban Art Walk from San Diego

Rp1.345.520
per adult
Tijuana Urban Art Walk from San Diego
Introduction Rosarito Day Tour from San Diego

Introduction Rosarito Day Tour from San Diego

Rp2.637.219
per adult
Introduction Rosarito Day Tour from San Diego
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.