Search Hotels in Greater South Side, Des Moines

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
31 Dec - 1 Jan
Tomorrow
1 Jan - 2 Jan
This weekend
2 Jan - 4 Jan
Next weekend
9 Jan - 11 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Greater South Side hotels

Deluxe Room, 2 Queen Beds, Non Smoking | Desk, iron/ironing board, free cots/infant beds, rollaway beds
Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport
2.0 star property
Greater South Side
8.6 out of 10, Excellent, (1691)
"Breakfast was good and parking was close and snow removed."
United States
Deborah
The price is Rp1.056.573
Rp1.183.361 total
includes taxes & fees
7 Jan - 8 Jan 2026
Days Inn & Suites by Wyndham Des Moines Airport
Free daily continental breakfast
Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport
2.5 star property
Greater South Side
8.8 out of 10, Excellent, (1002)
"Friendly staff, clean room, comfy bed, and convenient shuttle."
United States
Cullanete
The price is Rp1.829.045
Rp2.048.530 total
includes taxes & fees
27 Jan - 28 Jan 2026
Hampton Inn Des Moines-Airport
Free daily buffet breakfast
Quality Inn & Suites Des Moines Airport

Quality Inn & Suites Des Moines Airport

Quality Inn & Suites Des Moines Airport
2.5 star property
Greater South Side
7.4 out of 10, Good, (1001)
"Great staff very helpful. "
United States
Cleo and Michaelle
The price is Rp1.056.573
Rp1.183.361 total
includes taxes & fees
8 Jan - 9 Jan 2026
Quality Inn & Suites Des Moines Airport
Reception
AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport

AmericInn by Wyndham Des Moines Airport
2.5 star property
Greater South Side
7.8 out of 10, Good, (1003)
"Staff was very helpful."
United States
Ronda
The price is Rp1.040.641
Rp1.165.518 total
includes taxes & fees
8 Jan - 9 Jan 2026
AmericInn by Wyndham Des Moines Airport
Property amenity
Holiday Inn Des Moines-Airport/Conf Center by IHG

Holiday Inn Des Moines-Airport/Conf Center by IHG

Holiday Inn Des Moines-Airport/Conf Center by IHG
3.0 star property
Greater South Side
8.2 out of 10, Very good, (601)
"Beautiful updated room. We had breakfast at the resturant and it was incredible"
United States
Stacy J
The price is Rp2.096.375
Rp2.347.939 total
includes taxes & fees
5 Jan - 6 Jan 2026
Holiday Inn Des Moines-Airport/Conf Center by IHG
Lobby
Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West
2.5 star property
14.9 km from Greater South Side
9.0 out of 10, Wonderful, (1005)
"Room was clean, staff was courteous and the bed was comfortable. "
United States
Craig
The price is Rp1.268.726
Rp1.420.973 total
includes taxes & fees
25 Jan - 26 Jan 2026
Fairfield Inn and Suites by Marriott Des Moines West
Free daily full breakfast
Holiday Inn Express Des Moines Ankeny by IHG

Holiday Inn Express Des Moines Ankeny by IHG

Holiday Inn Express Des Moines Ankeny by IHG
2.5 star property
17.5 km from Greater South Side
9.4 out of 10, Exceptional, (299)
"clean, friendly staff, room was well equipped"
United States
Colin
The price is Rp1.425.535
Rp1.596.600 total
includes taxes & fees
23 Jan - 24 Jan 2026
Holiday Inn Express Des Moines Ankeny by IHG
Free WiFi, bed sheets
Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA

Motel 6 West Des Moines, IA
2.0 star property
15.3 km from Greater South Side
7.8 out of 10, Good, (726)
"Nice clean room, friendly staff. "
United States
Cheryl
The price is Rp805.679
Rp902.280 total
includes taxes & fees
11 Jan - 12 Jan 2026
Motel 6 West Des Moines, IA
Lobby
Baymont by Wyndham Des Moines Airport

Baymont by Wyndham Des Moines Airport

Baymont by Wyndham Des Moines Airport
2.5 star property
Southwestern Hills, 6.2 km from Greater South Side
9.4 out of 10, Exceptional, (1172)
"Convenient location to restaurants"
United States
Sally
The price is Rp1.439.790
Rp1.612.565 total
includes taxes & fees
20 Jan - 21 Jan 2026
Baymont by Wyndham Des Moines Airport
Free buffet breakfast
La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA

La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA
3.0 star property
18 km from Greater South Side
9.2 out of 10, Wonderful, (1000)
"Great stay with dogs"
United States
Mindy
The price is Rp1.343.357
Rp1.504.560 total
includes taxes & fees
1 Jan - 2 Jan 2026
La Quinta Inn & Suites by Wyndham Ankeny IA - Des Moines IA
Lobby
Hampton Inn & Suites Altoona-Des Moines

Hampton Inn & Suites Altoona-Des Moines

Hampton Inn & Suites Altoona-Des Moines
2.5 star property
18.8 km from Greater South Side
9.2 out of 10, Wonderful, (675)
"Great place to stay!"
United States
Donald J
The price is Rp1.650.266
Rp1.848.298 total
includes taxes & fees
10 Jan - 11 Jan 2026
Hampton Inn & Suites Altoona-Des Moines
Property amenity
Country Inn & Suites by Radisson, Indianola, IA

Country Inn & Suites by Radisson, Indianola, IA

Country Inn & Suites by Radisson, Indianola, IA
2.5 star property
19.7 km from Greater South Side
9.0 out of 10, Wonderful, (716)
"I stay at this property multiple times a year and have always had a positive experience. "
United States
John
The price is Rp1.767.663
Rp1.979.784 total
includes taxes & fees
24 Jan - 25 Jan 2026
Country Inn & Suites by Radisson, Indianola, IA
Terrace/patio
Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University

Home2 Suites by Hilton Des Moines at Drake University
3.0 star property
Drake, 5.6 km from Greater South Side
9.4 out of 10, Exceptional, (1011)
"Great place to stay and the employees were super nice and helpful"
United States
Amy
The price is Rp1.567.753
Rp1.755.884 total
includes taxes & fees
4 Jan - 5 Jan 2026
Home2 Suites by Hilton Des Moines at Drake University
Free daily buffet breakfast
Drury Inn & Suites West Des Moines

Drury Inn & Suites West Des Moines

Drury Inn & Suites West Des Moines
3.0 star property
12.3 km from Greater South Side
9.4 out of 10, Exceptional, (1000)
"A great place to stay"
United States
Carol
The price is Rp1.676.932
Rp1.878.184 total
includes taxes & fees
5 Jan - 6 Jan 2026
Drury Inn & Suites West Des Moines
Exterior
Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG

Staybridge Suites Des Moines Downtown by IHG
3.0 star property
Historic East Village, 4.5 km from Greater South Side
9.4 out of 10, Exceptional, (1000)
"Staff was amazing. Room, pool, breakfast all spectacular. Enjoyed our stay. Will tell our friends and family and will come back "
United States
Amanda
The price is Rp1.492.619
Rp1.671.733 total
includes taxes & fees
4 Jan - 5 Jan 2026
Staybridge Suites Des Moines Downtown by IHG
Exterior
Courtyard Marriott Ankeny

Courtyard Marriott Ankeny

Courtyard Marriott Ankeny
3.0 star property
17.9 km from Greater South Side
8.8 out of 10, Excellent, (541)
"Location, easy check in, welcoming vibe. "
United States
Denise
The price is Rp1.553.833
Rp1.740.293 total
includes taxes & fees
10 Jan - 11 Jan 2026
Courtyard Marriott Ankeny
Exterior
Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG

Holiday Inn Express & Suites Des Moines Downtown by IHG
2.5 star property
Downtown Des Moines, 3.2 km from Greater South Side
9.2 out of 10, Wonderful, (979)
"Great room, good breakfast. "
United States
Jason
The price is Rp1.492.619
Rp1.671.733 total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Des Moines Downtown by IHG
Exterior
Hampton Inn West Des Moines Lake Drive

Hampton Inn West Des Moines Lake Drive

Hampton Inn West Des Moines Lake Drive
3.0 star property
14.9 km from Greater South Side
9.0 out of 10, Wonderful, (1003)
"Easy friendly check in. "
United States
Lisa
The price is Rp1.430.231
Rp1.601.858 total
includes taxes & fees
6 Jan - 7 Jan 2026
Hampton Inn West Des Moines Lake Drive
Exterior
Comfort Inn & Suites West Des Moines

Comfort Inn & Suites West Des Moines

Comfort Inn & Suites West Des Moines
2.5 star property
15.2 km from Greater South Side
8.8 out of 10, Excellent, (576)
"Convenient location"
United States
Todd
The price is Rp1.388.639
Rp1.555.276 total
includes taxes & fees
1 Jan - 2 Jan 2026
Comfort Inn & Suites West Des Moines
Lobby
La Quinta Inn & Suites by Wyndham Des Moines West Clive

La Quinta Inn & Suites by Wyndham Des Moines West Clive

La Quinta Inn & Suites by Wyndham Des Moines West Clive
3.0 star property
13.3 km from Greater South Side
8.6 out of 10, Excellent, (1005)
"Very clean with a great breakfast. My kiddos loved the pool!"
United States
Erica
The price is Rp1.190.406
Rp1.333.254 total
includes taxes & fees
25 Jan - 26 Jan 2026
La Quinta Inn & Suites by Wyndham Des Moines West Clive
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Greater South Side

Find the best Greater South Side areas for the activities you enjoy most.
State Historical Society of Iowa Museum which includes a high-rise building, landscape views and a city

Downtown Des Moines

The abundant dining options and live music are top of the list for many visitors to Downtown Des Moines. A stop by 801 Grand or Des Moines Civic Center might round out your trip.

Historic East Village

Historic East Village

Find beautiful government buildings, cultural attractions and a garden oasis in this older section of the city extending along a pretty riverfront.

Court District

Travellers come to Court District for its abundant dining options, and you can see top attractions like Science Center of Iowa and Principal Park while you're in town.

Drake

While visiting Drake, you might make a stop by sights like Knapp Center and Des Moines Community Playhouse.

Southwestern Hills

Though Southwestern Hills may not have many top sights, you can venture to the surrounding area to see attractions like Air Lanes Bowling Center and Gray’s Lake Park.

Top Greater South Side Hotel Reviews

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

10/10 Excellent
"Always fun to stay here , nice place it is a little old but still nice and fun for kids , main pool was nice and warm ! "
Emily 1-night trip
Posted 3 weeks ago
Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Frequently asked questions

What's it like in Greater South Side?
Travellers are sure to enjoy a stay in Des Moines's Greater South Side neighbourhood. Consider a visit to Gray's Lake Park as part of your Greater South Side travel plans.
What's the best accommodation in Greater South Side?
Based on Expedia customer reviews, Days Inn & Suites by Wyndham Des Moines Airport is the highest ranked property in Greater South Side. This hotel offers free breakfast and an indoor pool. Other favourite options in the area include Hampton Inn Des Moines-Airport and AmericInn by Wyndham Des Moines Airport.
How many hotels can I expect to find in Greater South Side?
With 16 Expedia hotels and other accommodation options in Greater South Side to choose from, this is a good starting point for exploring the greater Des Moines area.
If I need to cancel my hotel reservation in Greater South Side, will I receive a refund?
Yes, most room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Greater South Side.
What is there to do around this Des Moines neighbourhood?
Gray's Lake Park is an attraction you might want to check out while you're in Greater South Side. While you're out sightseeing, Air Lanes Bowling Center and Lauridsen Amphitheater are a couple of additional sights to visit in Des Moines.