South Central Houston Travel Guide
Houston
Visit South Central Houston
Popular places to visit
MD Anderson Cancer Center
If MD Anderson Cancer Center is what brings you to town, hopefully you'll have a chance to explore more of Houston.
Rice University
Enjoy the student vibe when you visit Rice University during your travels in Houston. Experience the area's acclaimed art galleries and great live music.
Houston Zoo
Feed a giraffe, catch a 4-D movie or cool off in the water park at this extraordinary zoo.
University of Houston
Take a campus tour or just explore the area of University of Houston during your travels in Houston. Experience the acclaimed theatre scene and lively festivals in this vibrant area.
Children's Museum of Houston
You can take time to visit Children's Museum of Houston during your travels to Houston. Experience the area's entertainment choices and acclaimed theatre scene.
Houston Natural Science Museum
You can spend time browsing the exhibits at Houston Natural Science Museum during your trip to Houston. Experience the area's acclaimed art galleries and entertainment choices.
Things to do
Houston Museum of Natural Sciences: Planetarium Ticket
Houston: Downtown Aquarium All Day Pass
Houston's Official City & Mural Tour!
NASA's Space Center Admission Plus Houston City Tour
Houston: Houston Botanic Garden Entry Ticket
Color Factory Houston Ticket
Top hotels in South Central Houston
Hotel Zaza Houston Museum District
Great staff all around and excellent location
Reviewed on 9 Apr 2026
Hilton Houston Plaza/Medical Center
Clean room. Comfortable bed and pillows. Very friendly staff that also followed up with me throughout my stay.
Reviewed on 10 Apr 2026
InterContinental Houston by IHG
Excellent
Reviewed on 9 Apr 2026
The Westin Houston Medical Center/Museum District
I found the bathroom to be quite surprising. I noticed that the solid door had been replaced with a glass one. My 10-year-old son almost bumped into it, which was a bit concerning. Also, the transparent glass allows you to see inside the bathroom, which might not be ideal for all guests. I believe ...
Reviewed on 9 Apr 2026
DoubleTree by Hilton Houston Medical Center Hotel & Suites
The lady at the breakfast buffet is wonderful. She's so friendly and helpful, perfect for the job!
Reviewed on 7 Apr 2026
Extended Stay America Suites Houston Med Ctr Braeswood Bl
Ok, simple hotel.
Reviewed on 8 Apr 2026
Other neighbourhoods around South Central Houston
Greater Third Ward
If you're spending time in Greater Third Ward, check out sights like Barbara Jordan & Mickey Leland Archives or Fertitta Center and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Midtown
Midtown is well liked for its restaurants and live music. If you're hoping to get in some sightseeing, Houston Fire Museum and Midtown Arts and Theater Center Houston are top spots, and you can jump on the metro at McGowen Station or Ensemble/HCC Station to get around.
East Downtown Houston
The restaurants and live music are just a few things visitors like about East Downtown Houston. Shell Energy Stadium and Giant Beatles Statues are worthwhile spots to check out, and you can hop on the metro at Leeland/Third Ward Station or EaDo/Stadium Station to get around the larger area.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.
