Lodging Image

Search Hotels in Isle of Palms South, Jacksonville

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Isle of Palms South hotels

1. Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
Isle of Palms, 2 km from Isle of Palms South
9.4 out of 10, Exceptional, (561 reviews)
"Great place to stay!"
United States
Chad
The price is Rp2.379.548
Rp2.700.787 total
includes taxes & fees
15 Aug - 16 Aug
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

2. Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
1.5 km from Isle of Palms South
8.4 out of 10, Very good, (787 reviews)
"Nice hotel for the money."
United States
Troy
The price is Rp2.723.992
Rp3.091.732 total
includes taxes & fees
25 Jul - 26 Jul
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

3. Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
1.9 km from Isle of Palms South
9.4 out of 10, Exceptional, (287 reviews)
"Great hotel and very convenient to Mayo."
United States
Margaret
The price is Rp3.116.103
Rp3.536.777 total
includes taxes & fees
26 Jul - 27 Jul
Hilton Jacksonville At Mayo Clinic

4. Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
2.9 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Great location. 10 mins from the beach access. Nice clean hotel. Will stay again."
United States
keilyn
The price is Rp2.045.861
Rp2.322.051 total
includes taxes & fees
26 Jul - 27 Jul
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

5. Element by Marriott Jacksonville Beach

Element by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 4.4 km from Isle of Palms South
9.6 out of 10, Exceptional, (571 reviews)
"Best hotel ever 😊"
United States
Tablo
The price is Rp3.189.938
Rp3.620.579 total
includes taxes & fees
26 Jul - 27 Jul
Element by Marriott Jacksonville Beach

6. Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
9.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,120 reviews)
"Would stay again! Great area too!!"
United States
Alicia Ann
The price is Rp2.849.439
Rp3.234.113 total
includes taxes & fees
20 Jul - 21 Jul
Hyatt Place Jacksonville / St. Johns Town Center

7. Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
3.5 km from Isle of Palms South
9.2 out of 10, Wonderful, (1,003 reviews)
"Great staff and location"
United States
Tiffany
The price is Rp1.923.461
Rp2.183.136 total
includes taxes & fees
16 Aug - 17 Aug
Holiday Inn Express Jacksonville Beach by IHG

8. Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
Oceanfront, 4.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (4,179 reviews)
"Great location!"
United States
JOHN
The price is Rp3.014.491
Rp3.421.448 total
includes taxes & fees
2 Aug - 3 Aug
Margaritaville Jacksonville Beach

9. TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
2.9 km from Isle of Palms South
9.2 out of 10, Wonderful, (640 reviews)
"This was one of the hotels I really enjoyed they have a whole refrigerator, hot top, plates, utensils, and let’s not forget the Free Breakfast from 6-9am. The staff is very welcoming, nice, friendly, and understanding. When I visit Jacksonville again this will be my hotel every stay I really enjoyed it all."
United States
Khalia
The price is Rp2.132.599
Rp2.420.499 total
includes taxes & fees
2 Aug - 3 Aug
TownePlace Suites by Marriott Jacksonville East

10. Best Western Mayport Inn & Suites

Best Western Mayport Inn & Suites
2.5 star property
8.9 km from Isle of Palms South
7.8 out of 10, Good, (766 reviews)
"Room was a little dated but clean, staff we very helpful breakfast was ok."
United States
john
The price is Rp2.214.319
Rp2.513.253 total
includes taxes & fees
26 Jul - 27 Jul
Best Western Mayport Inn & Suites

11. Fairfield Inn & Suites by Marriott Jacksonville Beach

Fairfield Inn & Suites by Marriott Jacksonville Beach
3.0 star property
Oceanfront, 5.2 km from Isle of Palms South
8.6 out of 10, Excellent, (959 reviews)
"Clean room friendly staff"
United States
Dorian
The price is Rp2.580.624
Rp2.929.008 total
includes taxes & fees
26 Jul - 27 Jul
Fairfield Inn & Suites by Marriott Jacksonville Beach

12. Wyndham Garden Jacksonville

Wyndham Garden Jacksonville
3.0 star property
15.3 km from Isle of Palms South
7.8 out of 10, Good, (1,961 reviews)
"Great location"
United States
Richard
The price is Rp1.435.472
Rp1.629.260 total
includes taxes & fees
19 Jul - 20 Jul
Wyndham Garden Jacksonville

13. Holiday Inn Jacksonville E 295 Baymeadows by IHG

Holiday Inn Jacksonville E 295 Baymeadows by IHG
3.0 star property
9.6 km from Isle of Palms South
8.6 out of 10, Excellent, (1,002 reviews)
"The front desk, staff and the staff Doing the breakfast were awesome. We will definitely stay there again."
United States
Fred
The price is Rp1.689.233
Rp1.917.279 total
includes taxes & fees
23 Jul - 24 Jul
Holiday Inn Jacksonville E 295 Baymeadows by IHG

14. Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
3.8 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,178 reviews)
"Excellent access to multiple places with ample parking, good breakfast options and clean rooms."
United States
Roberto
The price is Rp2.178.656
Rp2.472.775 total
includes taxes & fees
9 Aug - 10 Aug
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

15. Weekly Inn

Weekly Inn
2.0 star property
14.7 km from Isle of Palms South
7.6 out of 10, Good, (1,373 reviews)
"Very comfortable and clean."
United States
Laporsha
The price is Rp870.961
Rp988.541 total
includes taxes & fees
20 Jul - 21 Jul
Weekly Inn

16. Baymont by Wyndham Jacksonville/Butler Blvd

Baymont by Wyndham Jacksonville/Butler Blvd
2.5 star property
16.2 km from Isle of Palms South
8.2 out of 10, Very good, (1,422 reviews)
"Everything was perfect here I’ll definitely be back"
United States
Kelly
The price is Rp1.188.162
Rp1.348.563 total
includes taxes & fees
26 Jul - 27 Jul
Baymont by Wyndham Jacksonville/Butler Blvd

17. Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
3.7 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Breakfast was a hit and the pool is the best hotel pool we've seen in a long time!!"
United States
Patsy
The price is Rp1.772.925
Rp2.012.349 total
includes taxes & fees
16 Aug - 17 Aug
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

18. Four Points by Sheraton Jacksonville Baymeadows

Four Points by Sheraton Jacksonville Baymeadows
3.0 star property
15.5 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"The room was a great value for the price and in a good location"
United States
Tom
The price is Rp1.684.574
Rp1.911.992 total
includes taxes & fees
1 Aug - 2 Aug
Four Points by Sheraton Jacksonville Baymeadows

19. Embassy Suites by Hilton Jacksonville Baymeadows

Embassy Suites by Hilton Jacksonville Baymeadows
3.5 star property
14 km from Isle of Palms South
8.4 out of 10, Very good, (1,460 reviews)
"Clean room ,nice staff, good breakfast"
United States
Samantha
The price is Rp2.621.484
Rp2.975.424 total
includes taxes & fees
26 Jul - 27 Jul
Embassy Suites by Hilton Jacksonville Baymeadows

20. Best Western Oceanfront

Best Western Oceanfront
3.0 star property
Oceanfront, 4.6 km from Isle of Palms South
9.0 out of 10, Wonderful, (1,003 reviews)
"Nice place and good location."
United States
Erik
The price is Rp2.838.507
Rp3.221.705 total
includes taxes & fees
4 Aug - 5 Aug
Best Western Oceanfront
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Isle of Palms South

Find the best Isle of Palms South areas for the activities you enjoy most.

Amelia City

While visiting Amelia City, you might make a stop by sights like American Beach and Fernandina Beach.

Downtown Jacksonville

The picturesque St. Johns River meanders through the center of this hub of skyscrapers, cultural landmarks and exciting nightlife.

Oceanfront

While visiting Oceanfront, you might make a stop by sights like Oceanfront Park and Northeast Florida Beaches.

Southside

If you're spending some time in Southside, St. Johns Town Center and Orange Park Place Shopping Center are top sights worth seeing.

American Beach

If you're spending some time in American Beach, American Beach and Spanish Quarter Village are top sights worth seeing.

Top Isle of Palms South Hotel Reviews

Frequently asked questions

What is Isle of Palms South like?
Travellers will be sure to find plenty to entertain them in Jacksonville Beach's Isle of Palms South neighbourhood.
How many hotels can I expect to find in Isle of Palms South?
Expedia has 7 Isle of Palms South hotels and other accommodation options, and one might make a good home base for venturing out into the greater Jacksonville Beach area.
If I need to cancel my hotel reservation in Isle of Palms South, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, you might be able to still cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to view the best deals in Isle of Palms South.
What are the top things to see and do in Isle of Palms South?
Cradle Creek Preserve, Windsor Parke Golf Club and Jacksonville Beach Golf Club are just a few of the places to visit in and around Isle of Palms South. Windsor Commons Shopping Center and Harbor City Municipal Golf Course are also worth a visit when you're out sightseeing in Jacksonville Beach.