Search Hotels in Otay Mesa, San Diego

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Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very good, (1,729 reviews)
"great breakfast and nice staff"
United States
rosita
The price is Rp2.190.762
Rp2.492.079 total
includes taxes & fees
17 May - 18 May
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,007 reviews)
"Good for short stay"
Japan
Yuki
The price is Rp1.804.255
Rp2.052.340 total
includes taxes & fees
10 May - 11 May
Quality Suites San Diego Otay Mesa

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,898 reviews)
"Great stay"
United States
Zuhair
The price is Rp1.862.148
Rp2.257.006 total
includes taxes & fees
26 May - 27 May
Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.8 out of 10, Good, (1,008 reviews)
"Clean rooms Good breakfast Excellent staff"
United States
Dulce j
The price is Rp1.537.011
Rp1.693.668 total
includes taxes & fees
10 May - 11 May
Days Inn by Wyndham San Diego-East/El Cajon

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
26.3 km from Otay Mesa
9.2 out of 10, Wonderful, (1,003 reviews)
"Really nice staff and great hotel!"
Canada
Shana
The price is Rp2.718.110
Rp2.995.221 total
includes taxes & fees
31 May - 1 Jun
Courtyard by Marriott San Diego El Cajon

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very good, (1,015 reviews)
"Clean room, clean property, kind staff, great breakfast, very spacious rooms."
United States
Sergio
The price is Rp2.394.364
Rp2.633.801 total
includes taxes & fees
26 May - 27 May
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (641 reviews)
"Best hotel ever!"
United States
Nicholas
The price is Rp3.815.856
Rp4.204.934 total
includes taxes & fees
10 May - 11 May
SpringHill Suites by Marriott Chula Vista Eastlake

Heritage Inn La Mesa

Heritage Inn La Mesa
2.0 star property
24.3 km from Otay Mesa
7.0 out of 10, Good, (1,435 reviews)
"Good and quick good customer service"
United States
Angel
The price is Rp1.248.734
Rp1.376.043 total
includes taxes & fees
10 May - 11 May
Heritage Inn La Mesa

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,415 reviews)
"Clean room, beautiful landscaping, adequate breakfast, easy parking. "
United States
Deborah
The price is Rp2.698.106
Rp3.042.056 total
includes taxes & fees
18 May - 19 May
Lamplighter Inn & Suites at SDSU

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,617 reviews)
"Great stay"
United States
Helda
The price is Rp1.758.695
Rp1.934.564 total
includes taxes & fees
25 May - 26 May
La Quinta Inn by Wyndham San Diego Chula Vista

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very good, (1,474 reviews)
"We really enjoyed our stay here! Breakfast in the morning was great & staff was always friendly & helpful!"
United States
Megan
The price is Rp1.778.816
Rp1.960.256 total
includes taxes & fees
31 May - 1 Jun
Comfort Inn Chula Vista San Diego South

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very good, (1,639 reviews)
"Clean room, friendly and nice staff, easy parking and safe "
United States
Erik
The price is Rp1.338.799
Rp1.525.535 total
includes taxes & fees
13 May - 14 May
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,271 reviews)
"Clean room, nice staff, a simple breakfast, and free parking on site."
United States
Nicole
The price is Rp2.126.778
Rp2.419.211 total
includes taxes & fees
21 May - 22 May
Best Western Americana Inn

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,229 reviews)
"The parking was not bad at all the AC and all the amenities were really good to have during our trip"
United States
Jesus
The price is Rp1.322.107
Rp1.454.318 total
includes taxes & fees
12 May - 13 May
Hotel Palmeras Chula Vista

Springhill Suites San Diego Mission Valley

Springhill Suites San Diego Mission Valley
3.5 star property
28.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1,005 reviews)
"additional, the location is perfect for most of resorts, "
United States
xiaoyang
The price is Rp2.596.176
Rp2.984.175 total
includes taxes & fees
10 May - 11 May
Springhill Suites San Diego Mission Valley

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,132 reviews)
"The room was lovely and clean friendly staff, nice breakfast"
United Kingdom
Niki Andrew
The price is Rp2.202.064
Rp2.422.357 total
includes taxes & fees
25 May - 26 May
Holiday Inn Express San Diego South - Chula Vista by IHG

San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
4.0 star property
28.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,006 reviews)
"Good to stay "
United States
Tamaz
The price is Rp3.112.273
Rp3.577.375 total
includes taxes & fees
17 May - 18 May
San Diego Marriott Mission Valley

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.6 out of 10, Excellent, (1,441 reviews)
"Clean room, friendly staff "
United States
Avery
The price is Rp1.645.319
Rp1.813.059 total
includes taxes & fees
13 May - 14 May
Hercor Hotel - Urban Boutique

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very good, (1,000 reviews)
"Very comfortable room and close to cool restaurants"
United States
Samantha
The price is Rp1.566.592
Rp1.766.271 total
includes taxes & fees
11 May - 12 May
Berkshire Motor Hotel

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,133 reviews)
"Such an adorable property in a great location!"
United States
Kory
The price is Rp1.895.183
Rp2.192.675 total
includes taxes & fees
10 May - 11 May
The Rambler Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Ocean Beach.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! Most room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.
What is there to do in this San Diego neighbourhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.