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Check prices for these dates

Tonight
6 Nov - 7 Nov
Tomorrow
7 Nov - 8 Nov
This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Sanctuary hotels

A resort with a central pool, multiple lounge areas, and a beach view.

1. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,000 reviews)
"They could do better on the food for breakfast at the restaurant on the property"
United States
Carol
The price is Rp3.894.863
Rp4.975.642 total
includes taxes & fees
10 Nov - 11 Nov
Tween Waters Island Resort & Spa
A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.

2. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very good, (1,000 reviews)
"Staff was super friendly and made my family feel so welcome. Standouts were our waiter Dale at the Beach House and Jocaleb, a worker at the pool. We had an awesome stay and will return."
United States
Jeremy
The price is Rp3.717.659
Rp6.255.539 total
includes taxes & fees
1 Dec - 2 Dec
South Seas
A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

3. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
9.0 out of 10, Wonderful, (478 reviews)
"Beautiful grounds, restaurant and bar very nice, good beach access"
Canada
Ronald
The price is Rp4.689.296
Rp5.228.565 total
includes taxes & fees
19 Nov - 20 Nov
Casa Ybel Resort
A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

4. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,001 reviews)
"I love everything about this hotel"
United States
Yunior
The price is Rp4.055.098
Rp5.157.315 total
includes taxes & fees
22 Nov - 23 Nov
Marriott Sanibel Harbour Resort & Spa
A resort with multiple-story buildings, palm trees, and a well-maintained lawn.

5. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,412 reviews)
"It was a wonderful stay. We really enjoyed it."
United States
Elina
The price is Rp3.598.318
Rp4.516.250 total
includes taxes & fees
12 Nov - 13 Nov
Sanibel Island Beach Resort
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.

6. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,168 reviews)
"Great location"
United States
Nicole
The price is Rp4.862.611
Rp5.421.810 total
includes taxes & fees
30 Nov - 1 Dec
Island Inn
A pathway leading to a pool area with lounge chairs and umbrellas, surrounded by tropical plants and a thatched-roof structure.

7. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,001 reviews)
"Staff was amazingly friendly"
United States
Tamara
The price is Rp5.482.462
Rp7.262.238 total
includes taxes & fees
19 Nov - 20 Nov
Sanibel Inn
A pool area with lounge chairs and umbrellas, a beach with umbrellas and lounge chairs, and palm trees.

8. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,718 reviews)
"Love the resort and great access to beach"
United States
Lisa Renee
The price is Rp6.310.618
Rp8.225.863 total
includes taxes & fees
29 Nov - 30 Nov
Sundial Beach Resort & Spa
A large, clear swimming pool with multiple lounge areas and palm trees.

9. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (2,738 reviews)
"Everything about the resort was excellent"
United States
Lance
The price is Rp3.253.889
Rp4.540.002 total
includes taxes & fees
29 Nov - 30 Nov
Margaritaville Beach Resort Fort Myers
A resort with multiple buildings featuring blue roofs, a beach, and a clear view of the ocean.

10. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (109 reviews)
"Clean, quiet, perfect location. Easy access to the beach ⛱️."
United States
Mauricio
The price is Rp5.679.556
Rp6.332.705 total
includes taxes & fees
9 Nov - 10 Nov
Shalimar Beach Resort
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.

11. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (165 reviews)
"Very good on everything I love the location"
United States
George
The price is Rp2.861.259
Rp3.795.147 total
includes taxes & fees
1 Dec - 2 Dec
Off the Charts Inn & Out Island Resort
A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

12. Pink Shell Beach Resort and Marina

Pink Shell Beach Resort and Marina
4.0 star property
20.4 km from Sanctuary
9.4 out of 10, Exceptional, (1,489 reviews)
"It's nice place to stay"
United States
Mario
The price is Rp3.907.937
Rp5.552.623 total
includes taxes & fees
15 Nov - 16 Nov
Pink Shell Beach Resort and Marina
A balcony with a table and chairs, large windows, and a view of the sea.

13. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,000 reviews)
"Very clean and nice place!"
United States
Charles
The price is Rp2.657.615
Rp3.773.534 total
includes taxes & fees
15 Nov - 16 Nov
The Westin Cape Coral Resort At Marina Village
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

14. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,747 reviews)
"Very clean - nice breakfast - great parking"
United States
Sherri
The price is Rp1.808.200
Rp2.016.143 total
includes taxes & fees
12 Nov - 13 Nov
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
Living area

15. The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (85 reviews)
"The whole place was wonderful."
United States
April
The price is Rp3.020.218
Rp3.638.774 total
includes taxes & fees
10 Nov - 11 Nov
The Anchor Inn
A modern dining area with wooden flooring, white chairs, and large windows offering a view of the beach.

16. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,000 reviews)
"Convenient location, friendly staff and clean rooms."
United States
Stacy
The price is Rp3.917.284
Rp4.367.771 total
includes taxes & fees
7 Dec - 8 Dec
Best Western Plus Beach Resort
A spacious living room with a grey sofa, striped armchair, and a woven coffee table. Large windows offer a view of a tropical garden.

17. Driftwood Inn

Driftwood Inn
4.0 star property
Mid Island, 13.1 km from Sanctuary
10.0 out of 10, Exceptional, (11 reviews)
"Great place to stay on sanibel"
United States
Terri
The price is Rp3.515.141
Rp8.269.730 total
includes taxes & fees
9 Nov - 10 Nov
Driftwood Inn
A balcony with two lounge chairs and a table, overlooking a beach with a clear view of the ocean and distant cityscape.

18. DiamondHead Beach Resort

DiamondHead Beach Resort
3.5 star property
22.3 km from Sanctuary
9.2 out of 10, Wonderful, (1,330 reviews)
"excellent place will stay again!"
United States
James Edward
The price is Rp3.637.709
Rp4.866.337 total
includes taxes & fees
15 Nov - 16 Nov
DiamondHead Beach Resort
An outdoor seating area with wicker chairs and a central table, surrounded by lush greenery and palm trees.

19. THE Palmview AND Sandpiper Inns

THE Palmview AND Sandpiper Inns
3.5 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (230 reviews)
"Nice and clean, has everything you need, in the kitchen particularly, 5 minute walk to the beach and the staff were lovely checking in every so often."
United Kingdom
Callie
The price is Rp4.621.759
Rp6.161.332 total
includes taxes & fees
9 Nov - 10 Nov
THE Palmview AND Sandpiper Inns
A balcony with wicker furniture, a view of a beach, and a clear sky.

20. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
8.8 out of 10, Excellent, (2,180 reviews)
"It was great to be right on the beach! The restaurants were also good."
United States
Tanya
The price is Rp2.348.850
Rp3.024.114 total
includes taxes & fees
3 Dec - 4 Dec
Lani Kai Beachfront Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.
Off the Charts Inn & Out Island Resort
2.5 star property
9.6
Exceptional
165 reviews
View
Living area
The Anchor Inn
2.0 star property
10.0
Exceptional
85 reviews
View
A resort with a central pool, multiple lounge areas, and a beach view.
Tween Waters Island Resort & Spa
3.0 star property
8.6
Excellent
1,000 reviews
View
A resort with multiple-story buildings, palm trees, and a well-maintained lawn.
Sanibel Island Beach Resort
3.0 star property
9.2
Wonderful
2,412 reviews
View
A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.
South Seas
3.5 star property
8.4
Very good
1,000 reviews
View

Hotels recommended for families in Sanctuary

A resort with a central pool, multiple lounge areas, and a beach view.

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
Captiva
8.6 out of 10, Excellent, (1,000)
The price is Rp3.894.863
Rp4.975.642 total
includes taxes & fees
10 Nov - 11 Nov
Tween Waters Island Resort & Spa

Where to stay in Sanctuary

Find the best Sanctuary areas for the activities you enjoy most.
A coastal scene with a lighthouse, beach, and ocean.

Mid Island

If you're spending some time in Mid Island, Periwinkle Way and Sanibel Island Southern Beach are top sights worth seeing.

A coastal scene with a lighthouse, beach, and ocean.

West End

If you're spending some time in West End, J. N. Ding Darling National Wildlife Refuge and Bowman's Beach are top sights worth seeing.

A coastal scene with a lighthouse, beach, and ocean.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

A street lined with palm trees and a sign for Periwinkle Place Shops.

Beachview Country Club Estates

While visiting Beachview Country Club Estates, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

A beach with clear turquoise water, a sandy shore, and a weathered driftwood structure.

Gulf Shores

When in Gulf Shores, you can plan a visit to Bowman's Beach and J. N. Ding Darling National Wildlife Refuge, some noteworthy sights in the nearby area.

Top Sanctuary Hotel Reviews

A resort with a central pool, multiple lounge areas, and a beach view.
Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
Captiva

10/10 Excellent

Great location, excellent facilities and a short walk across the road to the beach to watch th sunset. Excellent and thoroughly recommend
United Kingdom
Andy
Reviewed August 8, 2026
Tween Waters Island Resort & Spa

Frequently Asked Questions

What is Sanctuary like?

Travellers are sure to enjoy a stay in Sanibel's Sanctuary neighbourhood. Consider a visit to J. N. Ding Darling National Wildlife Refuge as part of your Sanctuary travel plans.

How many hotels will I be able to find in the Sanctuary area?

When you want to find places to stay in Sanibel, start by booking one of Expedia's 8 hotels and other accommodation options in Sanctuary.

If I need to cancel my hotel reservation in Sanctuary, will I receive a refund?

Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals available in Sanctuary.

What is there to do around this Sanibel neighbourhood?

J. N. Ding Darling National Wildlife Refuge is an attraction you might want to check out while you're in Sanctuary. Castaways Marina and Blind Pass Beach are also worth a visit when you're out sightseeing in Sanibel.