Search Hotels in Santa Ana, Panama City

Start date: Check-in selected.
To Date
End date: Check-out

    Change your mind

    Book hotels with free cancellation

    Treat yourself

    Sign in to save 10% or more on thousands of hotels

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Top Trending Hotels Near Santa Ana, Panama City

Casco View Apartments
3.5 star property
9.4 out of 10, Exceptional, (48)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments
Hotel República
2.0 star property
6.6 out of 10, (177)
"Fantastic customer service"
United States
OLGA
Hotel República
ART CASCO The Hotel
2.0 star property
6.4 out of 10, (9)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel
Hostal La Cigarra
2.5 star property
7.4 out of 10, Good, (53)
"Helpful staff, secure, close to sights"
Australia
Suzanne
Hostal La Cigarra
Hotel Riazor
3.0 star property
3.8 out of 10, (11)
"Rough neighborhood "
Canada
Del
Hotel Riazor
La Manzana by Wynwood House
3.0 star property
7.0 out of 10, Good, (14)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is Rp835.985
Rp1.251.323 total
includes taxes & fees
23 Oct - 24 Oct
La Manzana by Wynwood House
Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is Rp2.419.835
Rp2.661.819 total
includes taxes & fees
5 Nov - 6 Nov
Room-sofa Bed Stay Rooftop Pool & Gym, A
Crowne Plaza Panama Airport by IHG
4.0 star property
8.4 out of 10, Very good, (2263)
"Great location "
United States
Juan
The price is Rp2.005.575
Rp2.206.133 total
includes taxes & fees
1 Nov - 2 Nov
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo
4.0 star property
9.2 out of 10, Wonderful, (1001)
"Very beautiful hotel with helpful staff. Very good dining options. "
United States
Joseph
The price is Rp3.275.626
Rp3.603.189 total
includes taxes & fees
24 Oct - 25 Oct
Central Hotel Panama Casco Viejo
La Concordia Boutique Hotel
4.0 star property
9.4 out of 10, Exceptional, (188)
"Clean, safety, nice staff, decoration and quite building "
United States
Claudia
The price is Rp3.720.132
Rp4.092.145 total
includes taxes & fees
27 Oct - 28 Oct
La Concordia Boutique Hotel
Hotel Coral Suites
3.5 star property
9.0 out of 10, Wonderful, (1013)
"Great location with spacious rooms "
United States
Paul
The price is Rp1.149.479
Rp1.264.427 total
includes taxes & fees
23 Oct - 24 Oct
Hotel Coral Suites
The Westin Playa Bonita Panama
5.0 star property
8.0 out of 10, Very good, (1007)
"Only here for a short stay, but enjoyed the facilities and staff!"
Canada
Leona
The price is Rp2.664.702
Rp2.931.172 total
includes taxes & fees
16 Nov - 17 Nov
The Westin Playa Bonita Panama
TRYP by Wyndham Panamá Centro
3.5 star property
9.0 out of 10, Wonderful, (1026)
"Great affordable dining and service "
United States
Sean
The price is Rp1.433.117
Rp1.576.428 total
includes taxes & fees
30 Oct - 31 Oct
TRYP by Wyndham Panamá Centro
Hotel Riu Plaza Panama
5.0 star property
9.0 out of 10, Wonderful, (4446)
"Great stay, clean, great restaurants, nearby for business travels"
United States
Christian
The price is Rp1.898.178
Rp2.087.996 total
includes taxes & fees
9 Nov - 10 Nov
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
4.5 star property
8.4 out of 10, Very good, (1142)
"Great stay "
United States
Mark
The price is Rp2.140.030
Rp2.354.033 total
includes taxes & fees
14 Nov - 15 Nov
Megapolis Hotel Panamá
Principe Hotel and Suites
3.0 star property
9.0 out of 10, Wonderful, (1535)
"A nice hotel with plenty of shopping and restaurants in the area"
United States
Neil
The price is Rp829.349
Rp912.284 total
includes taxes & fees
9 Nov - 10 Nov
Principe Hotel and Suites
Riande Aeropuerto Hotel & Casino
4.0 star property
8.6 out of 10, Excellent, (1888)
"Property location is great for the airport"
Canada
Amber
The price is Rp2.853.084
Rp3.138.392 total
includes taxes & fees
30 Oct - 31 Oct
Riande Aeropuerto Hotel & Casino
Hospedium Princess Hotel Panama
3.5 star property
7.6 out of 10, Good, (648)
"A proper place to wait for check-in time, comfortable and with AC should be nice"
United States
Sergio
The price is Rp919.583
Rp1.011.541 total
includes taxes & fees
25 Oct - 26 Oct
Hospedium Princess Hotel Panama
Novotel Panama City
4.0 star property
9.2 out of 10, Wonderful, (1036)
"Very friendly and accommodating staff. Breakfast was great."
United States
Shanaz
The price is Rp1.612.256
Rp1.773.482 total
includes taxes & fees
2 Nov - 3 Nov
Novotel Panama City
Plaza Paitilla Inn Hotel
3.5 star property
9.4 out of 10, Exceptional, (2138)
"Breakfast was great, friendly staff and walking distance to a small mall"
United States
Troy
The price is Rp2.620.715
Rp2.882.787 total
includes taxes & fees
4 Nov - 5 Nov
Plaza Paitilla Inn Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

While visiting San Felipe, you might make a stop by sights like Interoceanic Canal Museum and National Theater.

Top Santa Ana Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi. Another top choice in the area is Hostal La Cigarra.
How many hotels can I expect to find in Santa Ana?
Expedia has 109 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.