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Top Trending Hotels Near Santa Ana, Panama City

Casco View Apartments

3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (52)
"Great stay, would recommend."
United States
Brooke
Casco View Apartments

Hostal La Cigarra

2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
The price is Rp422.193
Rp464.479 total
includes taxes & fees
2 Jan - 3 Jan 2026
Hostal La Cigarra

Hotel República

2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
Hotel República

La Manzana by Wynwood House

3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is Rp1.273.572
Rp1.858.749 total
includes taxes & fees
9 Dec - 10 Dec
La Manzana by Wynwood House

ART CASCO The Hotel

2.0 star property
Santa Ana
5.8 out of 10, (10)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is Rp2.464.346
Rp2.710.781 total
includes taxes & fees
9 Dec - 10 Dec
Room-sofa Bed Stay Rooftop Pool & Gym, A

Casa Quijano 06 By Wynwood House

4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (4)
"Easy to find, seamless check-in "
Canada
Matthew
The price is Rp1.748.040
Rp2.472.228 total
includes taxes & fees
15 Dec - 16 Dec
Casa Quijano 06 By Wynwood House

Hotel Riu Plaza Panama

5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (4628)
"Awesome great place to stay "
United States
Herbert
The price is Rp2.038.675
Rp2.242.543 total
includes taxes & fees
8 Dec - 9 Dec
Hotel Riu Plaza Panama

The Westin Playa Bonita Panama

5.0 star property
7.5 km from Santa Ana
8.0 out of 10, Very good, (1003)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is Rp2.915.564
Rp3.207.120 total
includes taxes & fees
16 Dec - 17 Dec
The Westin Playa Bonita Panama

Megapolis Hotel Panamá

4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.4 out of 10, Very good, (1255)
"Excellent hotel very clean and staff very friendly "
United States
ALLENDRA
The price is Rp2.182.165
Rp2.400.382 total
includes taxes & fees
9 Dec - 10 Dec
Megapolis Hotel Panamá

Crowne Plaza Panama Airport by IHG

4.0 star property
21.1 km from Santa Ana
8.4 out of 10, Very good, (2300)
"The room was clean and the staff were nice! "
United States
CECILIA
The price is Rp1.831.280
Rp2.014.408 total
includes taxes & fees
23 Dec - 24 Dec
Crowne Plaza Panama Airport by IHG

ORHO HOTEL BOUTIQUE PANAMA Airport

2.0 star property
20.5 km from Santa Ana
9.0 out of 10, Wonderful, (32)
"Very nice boutique hotel"
United States
Fernando
The price is Rp1.997.760
Rp2.197.536 total
includes taxes & fees
8 Dec - 9 Dec
ORHO HOTEL BOUTIQUE PANAMA Airport

Riande Aeropuerto Hotel & Casino

4.0 star property
19.8 km from Santa Ana
8.6 out of 10, Excellent, (1858)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
The price is Rp2.081.841
Rp2.290.025 total
includes taxes & fees
13 Dec - 14 Dec
Riande Aeropuerto Hotel & Casino

Courtyard by Marriott Panama Metromall

4.0 star property
14.6 km from Santa Ana
8.8 out of 10, Excellent, (1003)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
The price is Rp1.683.945
Rp1.852.340 total
includes taxes & fees
5 Jan - 6 Jan 2026
Courtyard by Marriott Panama Metromall

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 star property
Obarrio, 4.1 km from Santa Ana
8.8 out of 10, Excellent, (1000)
"Clean room nice location "
United States
daniel
The price is Rp2.647.032
Rp2.911.735 total
includes taxes & fees
8 Dec - 9 Dec
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz, 12.7 km from Santa Ana
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is Rp3.858.174
Rp4.243.991 total
includes taxes & fees
14 Dec - 15 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

JW Marriott Panama

5.0 star property
Punta Pacifica, 4.3 km from Santa Ana
9.0 out of 10, Wonderful, (1005)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is Rp4.180.313
Rp4.598.344 total
includes taxes & fees
4 Jan - 5 Jan 2026
JW Marriott Panama

Plaza Paitilla Inn Hotel

3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2134)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
The price is Rp2.632.258
Rp2.895.484 total
includes taxes & fees
8 Dec - 9 Dec
Plaza Paitilla Inn Hotel

Decapolis Hotel Panama City

4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
8.6 out of 10, Excellent, (1433)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is Rp1.860.873
Rp2.046.960 total
includes taxes & fees
10 Dec - 11 Dec
Decapolis Hotel Panama City

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1103)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
The price is Rp1.981.112
Rp2.179.223 total
includes taxes & fees
24 Dec - 25 Dec
Ramada Plaza by Wyndham Panama Punta Pacifica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Punta Paitilla is known for its abundant dining options, and you can plan a trip to Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Vibrant Shopping Centres: Santa Ana boasts a range of shopping venues, perfect for family outings and leisurely exploration.
  • Scenic Avenida Balboa: Enjoy breathtaking views and impressive architecture along this iconic promenade.
  • Cultural Attractions: Discover historical museums and cathedrals that offer a glimpse into Panama's rich heritage.
  • Outdoor Activities: Engage in bike lanes, boat tours, and city walks for an adventurous experience.
  • Diverse Accommodation: Choose from various lodging options catering to both leisure and business travellers, ensuring a comfortable stay.

Find great hotels near Santa Ana

In Santa Ana, you’ll discover a delightful selection of accommodation options, ranging from hotels to apartments, perfect for every type of traveller. Whether you're seeking a city-themed retreat, a pet-friendly haven, or a comfortable base for business travel, Santa Ana has you covered. Many establishments offer essential amenities such as air conditioning and all-inclusive options, ensuring a pleasant stay in this charming area of Panama City.

  • Residencial & Hotel Palazzo: Experience the vibrant city life at Residencial & Hotel Palazzo, a comfortable 3-star hotel located just 1.4km from Santa Ana. Ideal for urban adventurers, this property offers a city-themed vacation experience with easy access to local attractions. Guests can enjoy well-appointed rooms and a welcoming atmosphere, making it a great base for exploring the bustling streets of Panama City.
  • Tantalo Hotel: Positioned a mere 644m from Santa Ana, the 3.5-star Tantalo Hotel is perfect for both business travellers and those seeking an exciting city escape. With a chic, contemporary design, this hotel features modern amenities and a vibrant social scene, including a rooftop bar that offers stunning views of the city skyline. Its prime location allows guests to immerse themselves in the local culture and nightlife, ensuring a memorable stay.
  • La Concordia Boutique Hotel: For a family-friendly and pet-friendly experience, look no further than La Concordia Boutique Hotel, located just 483m from Santa Ana. This 4-star establishment caters to families with children, offering amenities such as babysitting services and high chairs. The hotel is also welcoming to pets, with specific policies in place to ensure a comfortable stay for all guests. With its charming atmosphere and focus on family care, La Concordia is a delightful choice for those travelling with loved ones.

Where to stay near Santa Ana

Santa Ana, a vibrant neighbourhood in Panama City, offers an array of experiences for all types of travellers. Explore the stunning Avenida Balboa with its breathtaking views and impressive architectural elements. The friendly atmosphere and family-friendly options make it perfect for a leisurely visit. Nearby, you can discover beautiful places that reflect the charm of an Asian city, providing a unique blend of relaxation and luxury. Santa Ana truly captures the essence of Panamanian hospitality.

  • Panama City: As the vibrant capital of Panama, Panama City serves as a gateway to the rich culture and history of the country. Located in close proximity to Santa Ana, this bustling metropolis offers a mix of modern skyscrapers and historical sites. Visitors can indulge in shopping at various centres and enjoy the local beaches, parks, and lively streets. The city is particularly popular among families and business travellers, and with its year-round appeal, there’s always something to experience, whether it’s the vibrant nightlife or the serene parks.
  • Casco Viejo: A mere 644m from Santa Ana, Casco Viejo is a UNESCO World Heritage site renowned for its colonial charm and historical significance. This picturesque neighbourhood is filled with cobblestone streets, colourful buildings, and a variety of shops and restaurants. Popular for family outings and cultural explorations, visitors can enjoy relaxing at parks, shopping in the local area, or soaking up the sun at nearby beaches. The atmosphere here is energetic, particularly during peak seasons in January and March to April, making it a must-visit destination.
  • Barrio Chino: Just 322m from Santa Ana, Barrio Chino, or Chinatown, is a vibrant neighbourhood that celebrates Chinese culture within Panama. This area boasts a variety of shopping options, from bustling markets to modern shopping centres, as well as theatres showcasing local performances. Visitors can immerse themselves in the rich history at nearby museums and historic places of worship. With its peak visitor arrivals in February to March and December, Barrio Chino offers a unique blend of cultural experiences, making it an intriguing stop on your journey.

Things to do near Santa Ana

Santa Ana in Panama City is perfect for family, city, and business-themed vacations. Visitors can explore vibrant shopping centres and areas, while also enjoying activities such as bike lanes, boat tours, and city walks. Adventure seekers will find plenty to do, making it an ideal destination for those looking to experience the charm and excitement of Panama City.

Shopping

In Santa Ana, you can enjoy shopping at Albrook Shopping Mall, just 1.6km away, offering a vibrant mix of entertainment and family-friendly options. For a local experience, visit Avenida Central, 483m away, featuring a lively atmosphere perfect for souvenirs and gifts.

Recreation

Experience the vibrant atmosphere at Maracana Stadium, only 1.3km from Santa Ana, where you can enjoy exciting sports events. For a broader range of activities, Estadio Nacional Rod Carew and Estadio Rommel Fernandez, located 6 and 11.3km away respectively, also offer thrilling sports experiences.

Adventure

Embark on the Honeycreeper Ridge Trail, located 43.5km from Santa Ana, where you'll encounter breathtaking scenery and a true outdoor adventure. Experience the thrill of Gatun Eco Adventures, a zipline ropes course 48.3km away, offering exhilarating rides amidst lush surroundings and vibrant adventure vibes.

Nightlife

Experience the vibrant nightlife in Santa Ana by visiting the National Theatre, offering a blend of romance and culture just 966m away. For more theatrical charm, check out Anita Villalaz Theatre, located 1.3km away, or enjoy a show at Amador Theatre, a mere 483m from Santa Ana.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Ana

For a budget-friendly trip to Santa Ana, consider visiting between September and November when accommodation prices are lower. Tuesdays are the cheapest days to stay, while Saturdays tend to be more expensive. Utilise Expedia’s search tool to find the best deals based on your budget and preferences, and consider booking a package that combines flights and hotels for additional savings. Look for app deals and instant savings to further cut costs. Additionally, explore free activities in the area to make the most of your visit without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to refine your preferences, including your budget, preferred location, and ideal type of accommodation. To discover the best prices and offers, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservation in Santa Ana with your flights and activities through an Expedia package deal.

Find the best attractions near Santa Ana

Santa Ana, located in Panama City, offers a delightful mix of family-friendly, city-themed, and business-oriented activities. Visitors can explore captivating attractions such as hills, historical museums, and cathedrals, perfect for those seeking cultural immersion, scenic beauty, and outdoor adventures. Whether you're travelling with family or on a business trip, Santa Ana presents a variety of experiences that cater to every type of traveller.

  • Metropolitan Cathedral of Panama: This stunning cathedral, located 805m from Santa Ana, showcases a blend of architectural styles, reflecting Panama's rich cultural heritage. Its serene atmosphere and intricate details make it a must-visit for those seeking a glimpse into the nation's history.
  • Interoceanic Canal Museum: Situated 805m from Santa Ana, this museum offers an engaging exploration of the Panama Canal's history and significance. Interactive exhibits and informative displays provide a fascinating insight into this engineering marvel and its impact on global trade.
  • Ancon Hill: Just 966m from Santa Ana, Ancon Hill provides breathtaking views of the city and surrounding nature. Ideal for outdoor enthusiasts, the hill features trails that allow visitors to immerse themselves in Panamanian flora and fauna while enjoying panoramic scenery.

Best time to go to Santa Ana

The best time to visit Santa Ana is dependent on what kind of holiday you are seeking. April is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. November is its coolest month on average. At this time, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

Visiting Santa Ana is convenient with three major airports nearby. Panama City (PAC-Marcos A. Gelabert Intl.) is situated 3.2km away, with luxurious hotels such as W Panama and Bristol Panama, both offering 24-hour airport shuttles. Balboa (BLB-Panama Pacifico Intl.) is located 6.4km from Santa Ana, and the Sortis Hotel, Spa & Casino provides scheduled airport shuttle services. Lastly, Panama City (PTY-Tocumen Intl.) is 20.9km away, with hotels like Las Americas Golden Tower Panama and Hotel El Panama, both offering shuttle services to the airport. Each hotel ensures easy access to the respective airports for a seamless travel experience.

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Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Cinta Costera and Avenida Balboa while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Expedia customers rank Hostal La Cigarra the highest for a stay in Santa Ana.
How many hotels can I expect to find in Santa Ana?
Expedia has 112 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighbourhood. Albrook Shopping Mall, Amador Theater and Museum of Contemporary Art Panama are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Mi Pueblito and Iglesia de la Merced are also worth a stop.