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Our top choices for Santa Ana hotels

1. Casco View Life Residences

Casco View Life Residences
4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (106 reviews)
"Amazing location and comfort"
United States
Ruben
The price is Rp1.414.521
Rp2.092.793 total
includes taxes & fees
3 Oct - 4 Oct
Casco View Life Residences

2. Hotel Caracas - Casco Viejo

Hotel Caracas - Casco Viejo
3.0 star property
Santa Ana
8.0 out of 10, Very good, (19 reviews)
"great staff"
United States
Keith
The price is Rp718.086
Rp789.895 total
includes taxes & fees
5 Oct - 6 Oct
Hotel Caracas - Casco Viejo

3. Hotel República

Hotel República
2.0 star property
Santa Ana
6.8 out of 10, (197 reviews)
"Good location. Walking distance to shops and public transport."
Canada
Danilo
The price is Rp525.505
Rp1.656.016 total
includes taxes & fees
3 Oct - 4 Oct
Hotel República

4. Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (75 reviews)
"Excellent staff, close to metro and embassies. A good location, good room for a great price. I would stay again. "
United Kingdom
Mark
The price is Rp525.433
Rp577.976 total
includes taxes & fees
6 Oct - 7 Oct
Hostal La Cigarra

5. ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (13 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
The price is Rp661.476
Rp727.624 total
includes taxes & fees
3 Oct - 4 Oct
ART CASCO The Hotel

6. La Manzana Barrio Vivo by Wynwood

La Manzana Barrio Vivo by Wynwood
3.0 star property
Santa Ana
7.6 out of 10, Good, (19 reviews)
"Very clean and safe property"
United States
Javier Alberto Lindauer
The price is Rp1.252.230
Rp1.871.518 total
includes taxes & fees
4 Oct - 5 Oct
La Manzana Barrio Vivo by Wynwood

7. Hotel Riazor

Hotel Riazor
3.0 star property
Santa Ana
3.8 out of 10, (11 reviews)
"Rough neighborhood "
Canada
Del
The price is Rp485.082
Rp533.590 total
includes taxes & fees
3 Oct - 4 Oct
Hotel Riazor

8. Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1 review)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is Rp2.865.509
Rp3.152.060 total
includes taxes & fees
3 Oct - 4 Oct
Room-sofa Bed Stay Rooftop Pool & Gym, A

9. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
5.0 star property
Campo Alegre, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (5,991 reviews)
"Beautiful hotel, breakfast was wonderful, location was very convenient."
United States
Sandrelly
The price is Rp2.462.957
Rp2.709.253 total
includes taxes & fees
27 Oct - 28 Oct
Hotel Riu Plaza Panama

10. The Executive Hotel

The Executive Hotel
3.5 star property
Campo Alegre, 3.2 km from Santa Ana
9.2 out of 10, Wonderful, (1,272 reviews)
"great location, great hotel"
United States
Sandra
The price is Rp1.593.576
Rp1.752.934 total
includes taxes & fees
26 Oct - 27 Oct
The Executive Hotel

11. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
5.0 star property
San Felipe, 1.1 km from Santa Ana
9.8 out of 10, Exceptional, (753 reviews)
"Amazing service and beautiful hotel"
United States
Jose
The price is Rp7.114.536
Rp7.825.990 total
includes taxes & fees
6 Oct - 7 Oct
Sofitel Legend Casco Viejo, Panama City

12. Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
Punta Paitilla, 3.5 km from Santa Ana
8.6 out of 10, Excellent, (1,772 reviews)
"Hotel was amazing"
United States
Sheena
The price is Rp2.885.734
Rp3.174.307 total
includes taxes & fees
26 Oct - 27 Oct
Megapolis Hotel Panamá

13. Hotel San Felipe

Hotel San Felipe
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (457 reviews)
"The hotel was a great surprise. Great friendly knowledgeable staff. Super modern room with great decor. Massive comfortable bed."
United States
Eric
The price is Rp2.750.130
Rp3.025.143 total
includes taxes & fees
3 Oct - 4 Oct
Hotel San Felipe

14. Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
Punta Paitilla, 3.4 km from Santa Ana
9.4 out of 10, Exceptional, (2,227 reviews)
"Great location close to all the areas of Panama City. Hotel staff was helpful and the buffet breakfast great"
United States
Jennifer
The price is Rp1.938.868
Rp1.938.868 total
includes taxes & fees
15 Oct - 16 Oct
Plaza Paitilla Inn Hotel

15. Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo
4.0 star property
San Felipe, 0.9 km from Santa Ana
9.0 out of 10, Wonderful, (1,002 reviews)
"Great location and nice hotel."
United States
Olga
The price is Rp3.416.937
Rp3.758.631 total
includes taxes & fees
5 Oct - 6 Oct
Central Hotel Panama Casco Viejo

16. Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
Punta Paitilla, 3.6 km from Santa Ana
9.0 out of 10, Wonderful, (1,118 reviews)
"The breakfast was great and the rooms were comfortable"
United States
Armando
The price is Rp2.729.317
Rp3.002.249 total
includes taxes & fees
4 Oct - 5 Oct
Las Americas Golden Tower Panama

17. American Trade Hotel

American Trade Hotel
4.5 star property
San Felipe, 0.7 km from Santa Ana
9.4 out of 10, Exceptional, (818 reviews)
"Beautiful hotel"
United States
Ashleigh-Ann
The price is Rp3.220.406
Rp3.542.447 total
includes taxes & fees
12 Oct - 13 Oct
American Trade Hotel

18. Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino
4.0 star property
El Cangrejo, 3.5 km from Santa Ana
9.0 out of 10, Wonderful, (1,178 reviews)
"Breakfast was excellent"
United States
kevin
The price is Rp1.603.465
Rp2.751.942 total
includes taxes & fees
3 Oct - 4 Oct
Waymore Hotel Spa & Casino

19. Hilton Panama

Hilton Panama
5.0 star property
Bella Vista, 3 km from Santa Ana
9.0 out of 10, Wonderful, (1,000 reviews)
"Perfect location close to the financial district, local markets, and great restaurants."
United States
Simon
The price is Rp4.448.269
Rp4.893.096 total
includes taxes & fees
10 Oct - 11 Oct
Hilton Panama

20. Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco, 5.1 km from Santa Ana
9.6 out of 10, Exceptional, (1,364 reviews)
"excellent breakfast great location"
United States
Maria
The price is Rp1.878.345
Rp2.066.180 total
includes taxes & fees
1 Nov - 2 Nov
Ramada Plaza by Wyndham Panama Punta Pacifica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Santa Ana

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern indoor pool area with clear blue water, lounge chairs, and a wall of plants.
Casco View Life Residences
4.0 star property
9.0
Wonderful
106 reviews
View
A hotel corridor with a wooden railing, doors, and wall-mounted plants.
Hotel Caracas - Casco Viejo
3.0 star property
8.0
Very good
19 reviews
View
A restaurant with a long counter, chairs, and tables. There are plants and lights decorating the space.
Hostal La Cigarra
2.0 star property
7.6
Good
75 reviews
View
A modern hotel room with a large bed, a sofa, a TV, and a view of the city.
La Manzana Barrio Vivo by Wynwood
3.0 star property
7.6
Good
19 reviews
View
A hotel room with a large bed, a window with curtains, a city view, and a lamp.
Hotel República
2.0 star property
6.8
197 reviews
View

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top Santa Ana Hotel Reviews

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Vibrant Walking Tours: Explore Santa Ana through free walking tours led by knowledgeable locals, offering insights into the culture and history of the neighbourhood.
  • Historical Attractions: Visit notable sites such as the Santa Ana Church and the nearby San Miguel, enriching your experience with the area's historical significance.
  • Family-Friendly Atmosphere: Santa Ana provides a welcoming environment for families, making it an ideal destination for both leisure and business-themed holidays.
  • Diverse Accommodation: Choose from a variety of accommodations, including pet-friendly hotels and comfortable apartments tailored to suit all travellers.
  • Local Culture: Immerse yourself in the warm Panamanian culture, characterised by friendly locals and a lively atmosphere.

Find great hotels near Santa Ana

Discover the charm of Santa Ana, a vibrant area in Panama City, offering a diverse selection of accommodations to suit every traveller's needs. From inviting hotels to comfortable apartments, you’ll find pet-friendly options and facilities tailored for business and leisure. Experience the unique city-themed vibes and enjoy your stay in this captivating destination, with convenient access to Panama’s rich culture and attractions.

  • American Trade Hotel: The American Trade Hotel is a charming 4.5-star accommodation that captures the essence of romance and adventure. With a guest rating of 9.4 out of 10, this hotel is located 644m from Santa Ana. It is ideally suited for families and couples seeking both relaxation and excitement. Guests can indulge in various adventure sports, including nearby Segway tours, bicycle rentals, and hiking. The hotel offers amenities for children, such as breakfast options and travel cribs. Guests can enjoy delightful garden views from the restaurant and savour romantic dining experiences with room service and champagne services. For those looking to unwind, the hotel features outdoor pools and in-room massage services, making it a perfect getaway for relaxation.
  • Sofitel Legend Casco Viejo, Panama City: With a prestigious 5-star rating and an impressive guest rating of 9.8 out of 10, the Sofitel Legend Casco Viejo is a luxurious haven located 1km from Santa Ana. This elegant property caters to business travellers and those seeking a rejuvenating spa experience. Guests can indulge in a comprehensive range of spa services, including body scrubs and treatments, alongside a serene pool area with sun loungers. The hotel’s sophisticated atmosphere and high-end amenities create a refined environment perfect for unwinding after a busy day in the city.
  • Innfiniti Hotel & Suites: The Innfiniti Hotel & Suites offers a 3.5-star experience in the heart of the city, situated 1km from Santa Ana. This hotel caters to business travellers and those looking to immerse themselves in the urban landscape. Its central location allows easy access to local attractions and business centres, making it a convenient choice for professionals. The hotel features modern accommodations and essential amenities, ensuring guests have a comfortable and efficient stay during their visit to Panama City.

Where to stay near Santa Ana

Santa Ana, a vibrant neighbourhood in Panamá Province, offers a delightful blend of family-friendly atmospheres and business vibes. During your visit, immerse yourself in the warm Panamanian culture, where friendly locals enhance the lively experience. Explore nearby areas to uncover the best parts of Panama, characterised by luxurious relaxation and a welcoming environment. Whether you're seeking adventure or tranquillity, Santa Ana promises a memorable getaway.

  • Panama City: As the bustling capital of Panama, Panama City is a vibrant metropolis that blends modernity with rich history. Situated in close proximity to Santa Ana, the city offers a plethora of experiences for travellers. With consistent visitor numbers throughout the year, the city showcases a diverse cultural landscape, making it ideal for family, business, or city-themed adventures. Notably, you can explore various shopping centres and bustling malls, while local landmarks such as beaches and parks provide a refreshing escape from the urban hustle.
  • Casco Viejo: Located a mere 644m from Santa Ana, Casco Viejo is a historic neighbourhood that captures the essence of Panama's colonial past. This UNESCO World Heritage site is renowned for its charming streets, colonial architecture, and vibrant atmosphere. Visitors flock here for family-friendly activities, business meetings, and immersive city experiences. With its proximity to beaches and parks, plus an array of shopping options, Casco Viejo is an idyllic spot to enjoy leisurely strolls and cultural explorations.
  • Barrio Chino: Just 322m from Santa Ana, Barrio Chino, or Chinatown, is a lively neighbourhood that reflects the cultural diversity of Panama City. This vibrant area attracts visitors seeking business, family, and city-themed experiences. With its array of shopping centres and malls, it’s a haven for those looking to indulge in retail therapy. Additionally, the local museums and research facilities add an educational touch, making Barrio Chino a fascinating destination to explore the confluence of cultures in Panama.

Things to do near Santa Ana

Shopping

Nearby, you can explore the vibrant Mercado de Santa Ana, where local artisans offer unique crafts and souvenirs. For a more modern experience, visit Multiplaza Pacific Mall, featuring a range of international brands and local boutiques, perfect for finding gifts to take home.

Recreation

Wellness Centre Santa Ana offers a tranquil environment with holistic treatments, yoga classes, and meditation sessions to rejuvenate your mind and body. Nearby, Parque Natural Metropolitano provides scenic trails for hiking and birdwatching, allowing you to connect with nature while enjoying the beauty of Panama's diverse wildlife.

Adventure

Gatun Eco Adventures offers an exhilarating zipline and ropes course experience, located 48km from Santa Ana. Soar through the treetops and navigate challenging obstacles, immersing yourself in the lush surroundings and embracing the thrill of this outdoor adventure.

Nightlife

Explore the vibrant nightlife in Santa Ana by visiting Casa de la Cerveza for a variety of local brews. For a lively atmosphere, head to Bar El Bongo, where you can dance to rhythmic music and enjoy the company of locals and fellow travellers alike.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Ana

For a budget-friendly trip to Santa Ana, consider visiting between September and November when accommodation prices are lower. Tuesdays are the cheapest days to stay, while Saturdays tend to be more expensive. Utilise Expedia’s search tool to find the best deals based on your budget and preferences, and consider booking a package that combines flights and hotels for additional savings. Look for app deals and instant savings to further cut costs. Additionally, explore free activities in the area to make the most of your visit without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Utilise Expedia’s search tool to refine your preferences, including your budget, preferred location, and ideal type of accommodation. To discover the best prices and offers, sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservation in Santa Ana with your flights and activities through an Expedia package deal.

Find the best attractions near Santa Ana

Santa Ana in Panama City is an ideal destination for family and business-themed vacations, offering a delightful mix of culture and outdoor experiences. Visitors can explore local attractions such as the Santa Ana Church, Iglesia Santa Ana, and the nearby San Miguel, along with scenic hills and history museums that enrich the area’s historical significance. Whether you're seeking a cultural immersion or a leisurely day out, Santa Ana has something for everyone.

  • Metropolitan Cathedral of Panama: This stunning cathedral, located 805m from Santa Ana, showcases a blend of architectural styles, reflecting the rich cultural heritage of Panama. Its impressive façade and ornate interiors make it a significant religious and historical site.
  • Interoceanic Canal Museum: Situated 805m away, this museum offers fascinating insights into the history and significance of the Panama Canal. Visitors can explore interactive exhibits that capture the spirit of innovation and engineering behind this monumental achievement.
  • Independence Square: Also 805m from Santa Ana, this vibrant piazza serves as a gathering place, steeped in history and culture. Surrounded by colonial architecture, it is a perfect spot to immerse oneself in the local atmosphere and enjoy leisurely strolls.

Best time to go to Santa Ana

The best time to visit Santa Ana can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santa Ana falls in April, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature around Santa Ana falls in November, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

Reaching Santa Ana, Panama, is convenient with three major airports nearby. Panama City (PAC-Marcos A. Gelabert Intl.) is located 3km from Santa Ana, with luxurious hotels such as Hilton Panama and Sofitel Legend Casco Viejo, both offering various airport transportation services. Balboa (BLB-Panama Pacifico Intl.) is 6km away, featuring The Westin Playa Bonita Panama among other upscale options. Lastly, Panama City (PTY-Tocumen Intl.) is 21km from Santa Ana, where guests can stay at The Santa Maria, A Luxury Collection Hotel, with accessible airport shuttles. Each airport provides a range of transport services to ensure a seamless journey.

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighbourhood that travellers like for its seafood restaurants, shopping and parks. Are you looking for Santa Ana travel tips? Make sure that you visit Avenida Balboa and El Machetazo Santa Ana while you're in the neighbourhood.
Where is the best hotel for a stay in Santa Ana?
Based on our traveller data, Hotel Caracas - Casco Viejo is one of the top choices for your stay in Santa Ana. This hotel is a short 7-minute walk from Avenida Balboa, and it offers a restaurant and a bar. Another good choice for your stay in the area is Casco View Life Residences.
How many hotels can I expect to find in Santa Ana?
Expedia has 135 hotels and other accommodation options in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Santa Ana.
What is there to do in this Panama City neighbourhood?
If you're looking forward to a day of shopping in Santa Ana, consider El Machetazo Santa Ana or Avenida Balboa, and pick out the perfect souvenir. When you're sightseeing in Panama City, Albrook Shopping Mall and Avenida Central are also worth a stop.