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Check prices for these dates

Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Santa Isabel hotels

Lobby
Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali

Fairfield Inn & Suites by Marriott Mexicali
2.5 star property
Mexicali
9.6 out of 10, Exceptional, (1003)
"Staff friendly really clean overall Great hotel!!! A plus great location "
United States
Daniel
The price is Rp1.689.023
Rp1.908.596 total
includes taxes & fees
2 Jan - 3 Jan 2026
Fairfield Inn & Suites by Marriott Mexicali
Outdoor pool
Holiday Inn Express & Suites Mexicali by IHG

Holiday Inn Express & Suites Mexicali by IHG

Holiday Inn Express & Suites Mexicali by IHG
3.0 star property
Mexicali
9.4 out of 10, Exceptional, (1004)
"Great service, the room was really clean, decent breakfast. "
United States
Jose
The price is Rp2.207.145
Rp2.494.074 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express & Suites Mexicali by IHG
Free daily continental breakfast
City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali

City Express Plus by Marriott Mexicali
3.5 star property
Mexicali
8.6 out of 10, Excellent, (1003)
"Excellent hotel"
United States
Agustin
The price is Rp1.243.947
Rp1.405.658 total
includes taxes & fees
4 Jan - 5 Jan 2026
City Express Plus by Marriott Mexicali
Outdoor pool
Calafia Hotel

Calafia Hotel

Calafia Hotel
3.5 star property
Eguía
8.2 out of 10, Very good, (1001)
"The room was nice and clean. We stayed for a couple of nights and were very happy with our visit."
United States
Lauren
The price is Rp1.296.407
Rp1.464.940 total
includes taxes & fees
21 Dec - 22 Dec
Calafia Hotel
Property amenity
Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali

Courtyard by Marriott Mexicali
3.0 star property
Mexicali
9.4 out of 10, Exceptional, (819)
"Great location, clean hotel rooms, friendly staff. "
United States
Elizabeth
The price is Rp1.739.192
Rp1.965.287 total
includes taxes & fees
24 Dec - 25 Dec
Courtyard by Marriott Mexicali
Interior entrance
Sleep Inn Mexicali

Sleep Inn Mexicali

Sleep Inn Mexicali
3.0 star property
Mexicali
8.4 out of 10, Very good, (1003)
"Friendly staff, clean rooms "
United States
Sara
The price is Rp1.029.958
Rp1.246.249 total
includes taxes & fees
19 Jan - 20 Jan 2026
Sleep Inn Mexicali
Front of property – evening/night
Hotel Araiza Mexicali

Hotel Araiza Mexicali

Hotel Araiza Mexicali
4.0 star property
Mexicali
8.6 out of 10, Excellent, (1722)
"Great hotel "
United States
Beatriz
The price is Rp1.961.608
Rp2.216.634 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Araiza Mexicali
Exterior
Hotel Lucerna Mexicali

Hotel Lucerna Mexicali

Hotel Lucerna Mexicali
4.0 star property
Mexicali
9.2 out of 10, Wonderful, (1431)
"Great stay! "
United States
Fabiola
The price is Rp1.748.058
Rp1.975.306 total
includes taxes & fees
4 Jan - 5 Jan 2026
Hotel Lucerna Mexicali
Front of property
Hotel Cosmos Don Carlos

Hotel Cosmos Don Carlos

Hotel Cosmos Don Carlos
3.0 star property
Eguía
8.0 out of 10, Very good, (491)
"Great stay!"
United States
Gustavo Adolfo
Hotel Cosmos Don Carlos
Lobby
City Express Junior by Marriott Mexicali

City Express Junior by Marriott Mexicali

City Express Junior by Marriott Mexicali
3.0 star property
Mexicali
7.8 out of 10, Good, (1001)
"Excellent location and great price. Will definitely stay here again"
United States
Luis
The price is Rp1.085.438
Rp1.226.544 total
includes taxes & fees
9 Jan - 10 Jan 2026
City Express Junior by Marriott Mexicali
Front of property
Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña

Extended Suites Mexicali Cataviña
3.0 star property
Mexicali
8.0 out of 10, Very good, (2204)
"Very nice people clean rooms all new appliances excellent service and great location will recommend to anyone looking for good rest! "
United States
JOSE
Extended Suites Mexicali Cataviña
Daily cooked-to-order breakfast (MXN 290 per person)
Real Inn Mexicali

Real Inn Mexicali

Real Inn Mexicali
4.0 star property
Civic Center
8.2 out of 10, Very good, (1553)
"It was a good stay. "
United States
Miguel
The price is Rp1.457.250
Rp1.646.693 total
includes taxes & fees
1 Jan - 2 Jan 2026
Real Inn Mexicali
Front of property – evening/night
Hotel del Norte

Hotel del Norte

Hotel del Norte
3.0 star property
Mexicali Historic Center
8.2 out of 10, Very good, (1000)
"Lots of food choices. Safe."
United States
Eddie
The price is Rp807.028
Rp1.013.636 total
includes taxes & fees
19 Jan - 20 Jan 2026
Hotel del Norte
Free daily continental breakfast
City Express by Marriott Mexicali

City Express by Marriott Mexicali

City Express by Marriott Mexicali
3.0 star property
Mexicali
8.2 out of 10, Very good, (1004)
"The are is safe and nice restaurants around. "
United States
Judy
The price is Rp1.281.538
Rp1.448.138 total
includes taxes & fees
28 Dec - 29 Dec
City Express by Marriott Mexicali
Reception
Motel Olimpo

Motel Olimpo

Motel Olimpo
2.0 star property
Mexicali
8.0 out of 10, Very good, (2)
"Nice and a clean place. "
United States
Sonia
The price is Rp605.552
Rp696.379 total
includes taxes & fees
20 Jan - 21 Jan 2026
Motel Olimpo
Exterior
One Mexicali

One Mexicali

One Mexicali
3.0 star property
Mexicali
7.8 out of 10, Good, (1000)
"NICE PLACE"
United States
ROBERTO
The price is Rp1.170.610
Rp1.322.790 total
includes taxes & fees
28 Dec - 29 Dec
One Mexicali
Garden
Hotel Colonial Mexicali

Hotel Colonial Mexicali

Hotel Colonial Mexicali
3.5 star property
Civic Center
8.0 out of 10, Very good, (1000)
"Great hotel"
United States
Juan
Hotel Colonial Mexicali
Double Room | Free WiFi, bed sheets
Motel Diana

Motel Diana

Motel Diana
2.5 star property
Mexicali
8.8 out of 10, Excellent, (8)
"Bed was hard "
United States
Luger
The price is Rp524.817
Rp603.546 total
includes taxes & fees
19 Jan - 20 Jan 2026
Motel Diana
Interior
Hotel Siesta Real

Hotel Siesta Real

Hotel Siesta Real
3.0 star property
Mexicali
8.2 out of 10, Very good, (901)
"Easy Parking and Excellent Restaurant "
United States
ARTURO
The price is Rp1.422.702
Rp1.607.653 total
includes taxes & fees
21 Dec - 22 Dec
Hotel Siesta Real
Double Room, 2 Queen Beds | Iron/ironing board, free rollaway beds, free WiFi
Motel Las Fuentes

Motel Las Fuentes

Motel Las Fuentes
2.5 star property
Mexicali
7.8 out of 10, Good, (147)
"Clean and quiet"
Mexico
Luis
The price is Rp572.961
Rp704.745 total
includes taxes & fees
20 Jan - 21 Jan 2026
Motel Las Fuentes
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Isabel Hotel Reviews

Hotels in Santa Isabel with star rating

Frequently asked questions

What's the best place for a stay in Santa Isabel?
Hotel Lucerna Mexicali, located 7.5 mi (12.1 km) from the heart of Santa Isabel, is a top choice for your stay, based on our traveller data. Other good choices for your stay in the area are Hotel Araiza Mexicali and Real Inn Mexicali. See all available top hotels, or vacation rentals in Santa Isabel.
If I need to cancel my hotel reservation in Santa Isabel, will I receive a refund?
Yes! You'll find that most hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, it might still be possible to cancel it and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Isabel.
What is staying in Santa Isabel like?
Visitors to Santa Isabel will definitely find plenty to explore and enjoy. There are 70 hotels and other accommodation options in the surrounding area. Find out more about Santa Isabel.
What is there to see in Santa Isabel?
Places to visit in the wider area include Mexicali Border Port I, City Forest and Zoo and Plaza Comercial La Cachanilla. You'll also find Eagles Nest Stadium and Imperial Valley Mall in the area. Take a look at what more there is to see and do in Expedia's Santa Isabel guide.
What's the seasonal weather like in Santa Isabel?
The hottest months are usually July and August, with an average temperature of 34°C, while the coldest months are December and January, with an average of 16°C. Average annual precipitation for Santa Isabel is 84 mm.