A calm lake with a row of canoes on the shore and a single canoe on the water.

Southern Minnesota hotel guide. Best Western hotel in Southern Minnesota, Minnesota

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
24 Oct - 25 Oct
Tomorrow
25 Oct - 26 Oct
Next weekend
30 Oct - 1 Nov
In two weeks
6 Nov - 8 Nov

Our top choices for Southern Minnesota Best Western

1. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
United States
Vicky
Rp1.711.091
Rp1.969.896 total
includes taxes & fees
29 Oct - 30 Oct
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2. Best Western Fairmont

Best Western Fairmont
Fairmont
United States
Harlsnd
Rp2.314.208
Rp2.565.878 total
includes taxes & fees
5 Nov - 6 Nov
Best Western Fairmont
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Southern Minnesota Hotel Reviews

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent
"Staff was extremely helpful and knowledgeable. Restaurant was clean and food was great. Very close to everything and parking was easy and inexpensive."
Rebecca 3-night trip
Posted less than an hour ago
Hotel Indigo Rochester – Mayo Clinic Area by IHG
AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic

10/10 Excellent
"nice breakfast"
Kristine 1-night trip
Posted less than an hour ago
AmericInn by Wyndham Rochester Near Mayo Clinic
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent
"B"
Linda 1-night trip
Posted 2 hours ago
Hyatt House Rochester/Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

10/10 Excellent
"We had returned for another round of days at Mayo Clinic. We stayed here for a previous appointment at Mayo. The Staff is very friendly and helpful. The Shuttle Staff, Shelly and Eric got us to our appointments safely and in a timely manner. There is alot of construction going on in Rochester making commuting to Mayo Clinic a very anxious prospect. The Shuttle service is a Blessing. Rooms are clean, beds are comfortable with enough pillows to make you feel comfortable. Breakfast was good and actually earlier than posted which is amazing in light of needing to catch an early Shuttle. Our room lock stopped working after a long day at Mayo. The desk staff notified maintenance who promptly came and changed the battery and everything was good again. Would like to thank the staff for making a stressful visit so much easier."
Marilyn 3-night trip
Posted 2 hours ago
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Brentwood Inn & Suites

Brentwood Inn & Suites

8/10 Good
"While the property is old, I found it very clean. Location is excellent. Bed was not great. Staff was incredibly accommodating."
Alicia 2-night trip
Posted 3 hours ago
Brentwood Inn & Suites
Express Suites Riverport Inn & Suites

Express Suites Riverport Inn & Suites

8/10 Good
"it’s good"
Ty 1-night trip
Posted 8 hours ago
Express Suites Riverport Inn & Suites
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"The hotel was very nice and convenient for travel to the Mayo Clinic with direct access to the underground walk way. The room was clean and nice to have the continental breakfast option. Construction was taking place outside of the hotel to improve the Mayo Clinic buildings in the area. The windows seemed to be rather low on their sound proofing ability. Almost seemed like the windows were open at times."
Angela 5-night trip
Posted 1 day ago
Kahler Inn and Suites - Mayo Clinic Area
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

10/10 Excellent
"Close to Mayo with hourly shuttle service. Also parking underground was secure. Good breakfast included and the bar/restaurant very nice too. We will stay here again when my husband gets his other shoulder done."
Grace 3-night trip
Posted 1 day ago
EVEN Hotel Rochester - Mayo Clinic Area by IHG
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

8/10 Good
"The staff were very friendly and helpful"
saida 2-night trip
Posted 1 day ago
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

Explore a world of travel with Expedia