A bench, a bicycle, and a lake surrounded by trees.

Upstate South Carolina hotel guide. Best Western hotel in Upstate South Carolina, South Carolina

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
1 Sept - 2 Sept
Tomorrow
2 Sept - 3 Sept
This weekend
4 Sept - 6 Sept
Next weekend
11 Sept - 13 Sept

Our top choices for Upstate South Carolina Best Western

A modern living room with a fireplace, two sofas, and a coffee table.
A reception area with two wooden reception desks, a blue accent wall, and a mounted television.
A hotel room with two beds, a desk, a TV, and a window with curtains.
A modern gym with various exercise equipment, motivational wall graphics, and a large window offering a view of the outdoors.

1. Best Western Spartanburg Northwest

Best Western Spartanburg Northwest
Spartanburg
United States
Porsche
Rp1.641.943
Rp1.859.007 total
includes taxes & fees
6 Sept - 7 Sept
Best Western Spartanburg Northwest
A fire pit with a bench on a concrete patio, surrounded by trees and a view of a body of water.
A modern restaurant with wooden flooring, bar seating, and a coffee station.
A Best Western hotel with a modern design, multiple flags, and well-lit signage.
A hotel room with two beds, a desk, a chair, a desk lamp, a bathroom with a mirror, and a window with curtains.

2. Best Western Travelers Rest Greenville

Best Western Travelers Rest Greenville
Travelers Rest
United States
Liz
Rp1.715.312
Rp1.886.843 total
includes taxes & fees
1 Oct - 2 Oct
Best Western Travelers Rest Greenville
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.
A multi-story hotel with a prominent entrance, parking area, and a car parked in front.

3. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
Rp1.717.439
Rp1.889.182 total
includes taxes & fees
4 Sept - 5 Sept
Best Western Seneca-Clemson
A modern lobby with a reception desk, seating area, and a television screen.
A hotel room with two beds, a desk with a lamp, a chair, a patterned rug, and a large window.
A swimming pool with lounge chairs and tables, surrounded by brick buildings and a covered seating area.
A hotel with a covered entrance, brick exterior, and a sign indicating it is a Best Western hotel.

4. Best Western Spartanburg I-26

Best Western Spartanburg I-26
Spartanburg
United States
Jonathan
Rp1.581.689
Rp1.755.676 total
includes taxes & fees
8 Sept - 9 Sept
Best Western Spartanburg I-26
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Top Upstate South Carolina Hotel Reviews

Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center

8/10 Good
"Enjoyed the stay, it was clean and would stay again"
Gerald 3-night trip
Posted 10 hours ago
Best Western Plus Clemson Hotel & Conference Center
Hilton Greenville

Hilton Greenville

10/10 Excellent
"Beautiful hotel"
Austin 1-night trip
Posted 21 hours ago
Hilton Greenville
Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"Fantastic hotel and price. The staff are so friendly and helpful. This is an older property so it’s not fancy, but very clean and well staffed."
Tammy 3-night trip
Posted 23 hours ago
Embassy Suites Greenville Golf Resort & Conference Center
Spartanburg Marriott

Spartanburg Marriott

10/10 Excellent
"From the first moment, we were impressed with the property. The common areas are clean. The registration representative was friendly and personable. All questions were answered. The room was clean with a great view. the location was perfect for our event. We went to see "Backbone" at the Chapman Cultural Arts center less than a mile away. The streets were quiet and we felt safe walking to and from the event after 9pm. Very happy with choice and will visit again."
Christophus 1-night trip
Posted 1 day ago
Spartanburg Marriott
Comfort Suites At WestGate Mall

Comfort Suites At WestGate Mall

8/10 Good
"None"
Edison 2-night trip
Posted 4 days ago
Comfort Suites At WestGate Mall

Explore a world of travel with Expedia