Our top choices for Upstate South Carolina hotels

Holiday Inn Express Gaffney by IHG

Gaffney

Kevin

Rp1.702.754 total

includes taxes & fees

12 Apr - 13 Apr

Hampton Inn Anderson/ Alliance Business Park

Anderson

osiry

Rp2.056.673 total

includes taxes & fees

5 Apr - 6 Apr

Hampton Inn Greer Greenville, SC

Greer

Tyler

Rp2.572.640 total

includes taxes & fees

2 Apr - 3 Apr

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Tara

Rp2.044.866 total

includes taxes & fees

5 Apr - 6 Apr

Clemson University's James F. Martin Inn

Clemson

Elliott

Rp2.808.322 total

includes taxes & fees

31 Mar - 1 Apr

Tru by Hilton Spartanburg

Spartanburg

Krystal

Rp1.727.024 total

includes taxes & fees

12 Apr - 13 Apr

Four Points by Sheraton Spartanburg

Spartanburg

Edsel

Rp1.906.454 total

includes taxes & fees

5 Apr - 6 Apr

Spartanburg Marriott

Spartanburg

Timothy

Rp2.224.040 total

includes taxes & fees

12 Apr - 13 Apr

3 restaurants, breakfast, dinner served; Modern European cuisine

AC Hotel by Marriott Spartanburg

Spartanburg

Terry

Rp2.619.844 total

includes taxes & fees

5 Apr - 6 Apr

Comfort Inn & Suites Greer - Greenville

Greer

susan

Rp1.772.203 total

includes taxes & fees

12 Apr - 13 Apr

Holiday Inn Express Hotel & Suites Spartanburg-North by IHG

Spartanburg

Christine

Rp1.713.265 total

includes taxes & fees

12 Apr - 13 Apr

Hampton Inn Easley

Easley

Wesley

Rp2.457.943 total

includes taxes & fees

6 Apr - 7 Apr

Hampton Inn & Suites Greenville Airport, SC

Greenville

Tara

Rp1.889.279 total

includes taxes & fees

12 Apr - 13 Apr

The Inn at Patrick Square

Clemson

Lauren

Rp2.996.801 total

includes taxes & fees

31 Mar - 1 Apr

Comfort Suites Greenville Airport

Greenville

Brandon

Rp1.890.726 total

includes taxes & fees

26 Apr - 27 Apr

Tru by Hilton Seneca Clemson

Seneca

Clifford

Rp2.082.972 total

includes taxes & fees

26 Apr - 27 Apr

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Karen

Rp1.580.160 total

includes taxes & fees

26 Apr - 27 Apr

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

HANS

Rp2.018.600 total

includes taxes & fees

13 Apr - 14 Apr

Hilton Garden Inn Anderson

Anderson

Sadie

Rp1.872.151 total

includes taxes & fees

13 Apr - 14 Apr

Quality Inn Seneca Clemson Area US-123

Downtown

Billy

Rp1.557.811 total

includes taxes & fees

12 Apr - 13 Apr

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Holiday Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Room was very roomy with plenty of extra linens. Very accessible to shopping and restaurants."

Aparthotel

Full-sized fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Nice gym, good breakfast and the rooms are clean and well appointed. Good hotel stayed one night with my family "

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Stay at Jos Taylor Retreat: 9 Mi to Greenville!

Taylors

"This rental is a time capsule that takes you back to Grandma and Grandpa's home. The owner is great to communicate with, as well as their property manager. Quaint older furniture, complete with blankets on the couches. There's all you need to cook and even a great cast-iron frying pan. I wish we had stayed here longer."

Cottage

Blue Ridge Mtn Cabin Near Hiking & Biking Trails!

Travelers Rest

"Great place for the weekend "

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

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Stay near popular Southeastern United States attractions

Clemson University

4.7/5 (738 reviews)

Take a campus tour or just explore the area of Clemson University during your travels in Clemson. Experience the area's theatre scene or attend a football match.

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Fred W. Symmes Chapel

4.8/5 (13 reviews)

You can find out about the history of Cleveland with a visit to Fred W. Symmes Chapel. Wander the lakeside and forests in this relaxing area.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, sports teams and sights from Frankie's Fun Park to The Shops at Greenridge.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Hyatt Regency Greenville

8/10 Good

"Property was clean for the most part. Lot of issues with people on the floors partying, but I think it was a special group that was in town for something. Had to call the front desk for security as we couldn’t sleep it almost 1 AM. But the staff was amazing. That’s for sure."