Search Business Hotels in South America

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

South America Accommodation: Most Popular Cities to Stay

HotelsHotels

Cartagena

Cartagena

Check availability on South America Business Hotels

Our top choices for South America business-friendly hotels

View from property
Radisson Blu Plaza El Bosque Santiago

Radisson Blu Plaza El Bosque Santiago

Radisson Blu Plaza El Bosque Santiago
4.0 star property
Las Condes
8.8 out of 10, Excellent, (1008)
"Clean Rooms, Staff was very kind and friendly."
United States
Ignacio
The price is Rp2.102.688
Rp2.102.688 total
25 Dec - 26 Dec
Radisson Blu Plaza El Bosque Santiago
Reception
Grand Hyatt Sao Paulo

Grand Hyatt Sao Paulo

Grand Hyatt Sao Paulo
5.0 star property
Itaim Bibi
9.4 out of 10, Exceptional, (1006)
"Very nice room. "
United States
Reinaldo
The price is Rp3.196.210
Rp3.356.020 total
includes taxes & fees
3 Jan - 4 Jan 2026
Grand Hyatt Sao Paulo
37-inch TV with cable channels
Pullman Santiago Vitacura

Pullman Santiago Vitacura

Pullman Santiago Vitacura
5.0 star property
Vitacura
9.0 out of 10, Wonderful, (907)
"Clean and quiet"
United States
Nathan
The price is Rp1.575.882
Rp1.575.882 total
28 Dec - 29 Dec
Pullman Santiago Vitacura
Outdoor pool, pool umbrellas, pool loungers
NH Collection Medellín Royal

NH Collection Medellín Royal

NH Collection Medellín Royal
5.0 star property
El Poblado
9.2 out of 10, Wonderful, (1000)
"Room was perfect, very modern settings and super comfortable beds."
United States
oscar
The price is Rp1.533.198
Rp1.533.198 total
22 Dec - 23 Dec
NH Collection Medellín Royal
Breakfast, lunch, dinner served; international cuisine
NM Lima Hotel

NM Lima Hotel

NM Lima Hotel
4.0 star property
San Isidro
9.2 out of 10, Wonderful, (1003)
"Excelent place, great food, nice people"
United States
Renato
The price is Rp1.297.026
Rp1.426.729 total
20 Dec - 21 Dec
NM Lima Hotel
Breakfast, lunch, dinner served; Peruvian cuisine
Pullman Lima San Isidro

Pullman Lima San Isidro

Pullman Lima San Isidro
4.0 star property
San Isidro
9.2 out of 10, Wonderful, (795)
"Everything was great about the hotel clean, the staff and amenities were all excellent."
United States
Nestor
The price is Rp1.637.093
Rp1.800.802 total
10 Jan - 11 Jan 2026
Pullman Lima San Isidro
2 restaurants, breakfast, lunch, dinner served; international cuisine
Hotel Plaza El Bosque Ebro

Hotel Plaza El Bosque Ebro

Hotel Plaza El Bosque Ebro
4.0 star property
Las Condes
9.0 out of 10, Wonderful, (1001)
"Simply a very pleasant hotel to stay at in a very nice area of town with plenty of great dining options nearby."
United States
Gerald
The price is Rp1.969.184
Rp2.136.064 total
19 Dec - 20 Dec
Hotel Plaza El Bosque Ebro
Premium bedding, minibar, in-room safe, desk
Hotel Madero Buenos Aires, WorldHotels Elite

Hotel Madero Buenos Aires, WorldHotels Elite

Hotel Madero Buenos Aires, WorldHotels Elite
4.5 star property
Puerto Madero
9.2 out of 10, Wonderful, (1003)
"The staff is absolutely wonderful. Hotel is great too!"
United States
Anthony Miles
The price is Rp3.662.050
Rp3.712.078 total
11 Jan - 12 Jan 2026
Hotel Madero Buenos Aires, WorldHotels Elite
Exterior
Regal Pacific Buenos Aires

Regal Pacific Buenos Aires

Regal Pacific Buenos Aires
4.5 star property
El Centro
9.0 out of 10, Wonderful, (1000)
"This is an excellent hotel in Buenos Aires "Microcentro". Good hotel and close by walking distance to Buenos Aires main attractions. Good place to stay also for business purposes."
United States
Jorge
Regal Pacific Buenos Aires
Lobby sitting area
GHL Hotel Capital

GHL Hotel Capital

GHL Hotel Capital
4.0 star property
Fontibon
9.2 out of 10, Wonderful, (1352)
"Ir was really grat staying in this hotel"
United States
Julio
The price is Rp1.320.844
Rp1.320.844 total
26 Dec - 27 Dec
GHL Hotel Capital
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top South America Hotel Reviews

Lennox Hotel Buenos Aires

Lennox Hotel Buenos Aires

10/10 Excellent
"The hotel is about 5-10 mins to the Theatre district and other major attractions. The hotel itself is clean & modern inside, staff were very good, progressional & friendly. I’d definitely stay again."
Richard 2-night trip
Posted 3 weeks ago
Lennox Hotel Buenos Aires

Explore a world of travel with Expedia

Frequently asked questions

Why book your business-friendly hotel in South America with Expedia?
Here at Expedia, our top task is to help you choose the perfect stay at the right price. From luxurious, corporate-friendly getaways to affordable hotels filled with handy amenities, you'll have your next work trip organised in just a few clicks.
How can I find cheap business-friendly hotels in South America?
When work takes you to South America, our "business friendly" filter will help you find the right hotel. From fast WiFi to meeting rooms and workspaces, they have the amenities you need to do your job. You can also narrow your search by your budget and preferred star rating to view the cheapest properties.