Visit South Main
Popular places to visit
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the great live music and acclaimed theatre scene in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theatre scene and entertainment choices in this vibrant area.
Rice University
Walk around the campus of Rice University, a top university in Houston. Experience the area's acclaimed art galleries and great live music.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art galleries and lively festivals in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
Things to do
Space Center Houston Admission Ticket
Houston Museum of Natural Sciences: Planetarium Ticket
Houston's Official City & Mural Tour!
Houston: Houston Botanic Garden Entry Ticket
Houston: Children's Museum Houston Entry Ticket
Top hotels in South Main
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
Staff was very nice
Reviewed on 21 Dec 2025
Hilton Houston Plaza/Medical Center
Great
Reviewed on 21 Dec 2025
Club Quarters Hotel Downtown, Houston
Wonderful experience great staff
Reviewed on 17 Dec 2025
The Whitehall Houston
Great hotel and friendly staff
Reviewed on 17 Dec 2025
Blossom Hotel Houston, Curio Collection by Hilton
I love this hotel!
Reviewed on 21 Dec 2025
The Royal Sonesta Houston Galleria
Great overall stay!!!
Reviewed on 16 Dec 2025
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Astrodome, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at M. D. Anderson Station or Museum District Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Continental Club or Midtown Arts and Theater Center Houston and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area.
River Oaks
Gardens and monuments are just a few things travellers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area.
