Search Hotels in South Main, Houston

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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,297 reviews)
"Hotel clean and convenient "
United States
Mitzi
The price is Rp1.718.900
Rp2.011.113 total
includes taxes & fees
20 Apr - 21 Apr
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Great location if you’re headed to NRG, room was very clean. Good for an overnight "
United States
Daisy
The price is Rp1.551.307
Rp1.815.029 total
includes taxes & fees
23 Apr - 24 Apr
Comfort Suites Houston near Medical Center- NRG Stadium

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,002 reviews)
"Great location"
United States
Jeremy
The price is Rp1.357.931
Rp1.588.779 total
includes taxes & fees
26 Apr - 27 Apr
Wingate Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (852 reviews)
"Room was clean. It had a musty smell though. "
United States
Ryan
The price is Rp1.271.986
Rp1.488.224 total
includes taxes & fees
11 May - 12 May
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,002 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is Rp1.154.241
Rp1.350.461 total
includes taxes & fees
17 May - 18 May
Quality Inn & Suites NRG Park - Medical Center

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
19.4 km from South Main
9.6 out of 10, Exceptional, (36 reviews)
"loveeeee. so cute came here for spring break. comfy little spot definitely recommend!"
United States
Danielle
The price is Rp1.581.388
Rp1.850.224 total
includes taxes & fees
20 Apr - 21 Apr
Palace Inn Blue 290 W 43rd & Bingle Rd

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (27 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is Rp1.392.309
Rp1.629.003 total
includes taxes & fees
20 Apr - 21 Apr
Hotel Royale

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (166 reviews)
"This was a great location from downtown. The price was fair, and the rooms were spacious and clean. Great customer service!"
United States
Tarevea
The price is Rp1.566.348
Rp1.887.606 total
includes taxes & fees
23 Apr - 24 Apr
Palace Inn Blue Edgebrook

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (223 reviews)
"I always go to this hotel after comparing my stay at other hotels. This hotel is perfect for solo travelers and families."
United States
Regina
The price is Rp1.531.712
Rp1.792.104 total
includes taxes & fees
7 May - 8 May
Best Western Plus Pearland/Houston Medical Center Hotel

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,004 reviews)
"Clean and courteous staff."
United States
chris
The price is Rp1.455.908
Rp1.703.412 total
includes taxes & fees
11 May - 12 May
Tru by Hilton Houston Webster NASA

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,842 reviews)
"Very comfortable stay. Staff was very friendly, great location, 1 mile away from the airport car rental return, places to eat in walking distance next door to gas station. The room was nice for a 1 or 2 night stay."
United States
Tanasha
The price is Rp1.592.217
Rp1.872.765 total
includes taxes & fees
8 May - 9 May
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Crystal Inn - NorthWest - 290

Crystal Inn - NorthWest - 290
2.0 star property
24.8 km from South Main
9.8 out of 10, Exceptional, (52 reviews)
"The best hotel I’ve been in excellent rooms perfect customer service rooms are phenomenal"
United States
Michael
The price is Rp1.715.118
Rp1.972.438 total
includes taxes & fees
20 Apr - 21 Apr
Crystal Inn - NorthWest - 290

Home2 Suites by Hilton Houston Pasadena

Home2 Suites by Hilton Houston Pasadena
3.0 star property
24.3 km from South Main
9.4 out of 10, Exceptional, (860 reviews)
"Breakfast offerings were limited, but overall, the stay was great. Beds were comfortable, room was clean, staff was friendly. Felt safe in our hotel and would gladly stay again."
United States
Travis
The price is Rp1.644.644
Rp1.924.137 total
includes taxes & fees
23 Apr - 24 Apr
Home2 Suites by Hilton Houston Pasadena

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,720 reviews)
"Perfect hotel if need to stay close to the airport. Great service and amenities, very nice and spacious rooms."
Canada
Ashraf
The price is Rp1.884.774
Rp2.205.185 total
includes taxes & fees
3 May - 4 May
SpringHill Suites by Marriott Houston Intercontinental Arprt

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,201 reviews)
"Super clean and close to the AirPort "
United States
Keiry
The price is Rp2.176.987
Rp2.547.074 total
includes taxes & fees
8 May - 9 May
Courtyard by Marriott Houston Intercontinental Airport

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,002 reviews)
"Great food at the bar. "
United States
Markus
The price is Rp1.730.929
Rp2.044.954 total
includes taxes & fees
25 Apr - 26 Apr
Doubletree by Hilton Houston Hobby Airport

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
22.6 km from South Main
8.8 out of 10, Excellent, (776 reviews)
"This location has a gym, hot tub, and pool. The staff are all very courteous and helpful. The room was exceptionally clean and comfortable. I will definitely visit this location again."
United States
David
The price is Rp1.373.229
Rp1.551.748 total
includes taxes & fees
4 May - 5 May
Best Western Plus Manvel Inn & Suites

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Room clean, staff and amenities top notch."
United States
Keith
The price is Rp1.581.388
Rp1.850.224 total
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.6 out of 10, Excellent, (4,085 reviews)
"Good location and value "
United States
Marc
The price is Rp1.686.241
Rp1.972.953 total
includes taxes & fees
20 Apr - 21 Apr
Club Quarters Hotel Downtown, Houston

Hilton Houston North

Hilton Houston North
3.5 star property
30.5 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"Very convenient location, clean, and staff was exceptional "
United States
Shatoria
The price is Rp2.356.268
Rp2.756.833 total
includes taxes & fees
24 Apr - 25 Apr
Hilton Houston North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,001 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,297 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,002 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
852 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,002 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on our traveller data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 9-minute walk from NRG Stadium, and it offers a restaurant and an outdoor pool.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 66 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.