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Our top choices for South Main hotels

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is Rp1.656.615
Rp1.938.239 total
includes taxes & fees
2 Feb - 3 Feb
Comfort Suites Houston near Medical Center- NRG Stadium

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (829 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is Rp1.317.186
Rp1.541.107 total
includes taxes & fees
20 Jan - 21 Jan
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,001 reviews)
"Clean rooms, quiet property. We will be back again. "
United States
Javier
The price is Rp1.278.346
Rp1.495.513 total
includes taxes & fees
25 Jan - 26 Jan
Quality Inn & Suites NRG Park - Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (998 reviews)
"Easy access to stadium "
United States
Richard
The price is Rp1.840.683
Rp2.153.598 total
includes taxes & fees
19 Jan - 20 Jan
Wingate Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,207 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is Rp2.178.423
Rp2.548.756 total
includes taxes & fees
19 Jan - 20 Jan
Wyndham Houston near NRG Park/Medical Center

Four Points by Sheraton Houston Intercontinental Airport

Four Points by Sheraton Houston Intercontinental Airport
3.0 star property
29.9 km from South Main
8.4 out of 10, Very good, (1,006 reviews)
"This place was amazing! Stayed in 4 places in days, this was the absolute best !"
United States
Debra
The price is Rp1.418.508
Rp1.659.655 total
includes taxes & fees
30 Jan - 31 Jan
Four Points by Sheraton Houston Intercontinental Airport

Comfort Suites Houston West at Clay Road

Comfort Suites Houston West at Clay Road
2.5 star property
22.8 km from South Main
8.4 out of 10, Very good, (1,001 reviews)
"Safe hotel"
United States
Nick
The price is Rp1.234.440
Rp1.444.294 total
includes taxes & fees
29 Jan - 30 Jan
Comfort Suites Houston West at Clay Road

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31.1 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"It was a great stay "
United States
Thrideep
The price is Rp1.472.546
Rp1.731.997 total
includes taxes & fees
23 Jan - 24 Jan
Hilton Garden Inn Houston/Bush Intercontinental Airport

GreenTree Inn Houston IAH Airport

GreenTree Inn Houston IAH Airport
2.0 star property
31.4 km from South Main
6.6 out of 10, (1,003 reviews)
"It was ok, to spend a night waiting for a flight. "
United States
Hamlet
The price is Rp911.898
Rp1.066.920 total
includes taxes & fees
19 Jan - 20 Jan
GreenTree Inn Houston IAH Airport

Days Inn & Suites by Wyndham Houston Hobby Airport

Days Inn & Suites by Wyndham Houston Hobby Airport
2.5 star property
15.8 km from South Main
8.6 out of 10, Excellent, (1,002 reviews)
"Awesome friendly staff and spotless rooms. Kudos to the manager."
United States
Mauricio
The price is Rp1.249.638
Rp1.462.076 total
includes taxes & fees
19 Jan - 20 Jan
Days Inn & Suites by Wyndham Houston Hobby Airport

Hampton Inn & Suites Houston I-10 West Park Row

Hampton Inn & Suites Houston I-10 West Park Row
2.5 star property
29.3 km from South Main
8.8 out of 10, Excellent, (674 reviews)
"Great staff, Clean room. "
United States
Corliss
The price is Rp1.215.864
Rp1.433.200 total
includes taxes & fees
24 Jan - 25 Jan
Hampton Inn & Suites Houston I-10 West Park Row

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD
3.0 star property
28.8 km from South Main
9.0 out of 10, Wonderful, (980 reviews)
"Area is nice and quiet. Hotel was clean. "
United States
Isabel
The price is Rp1.337.450
Rp1.564.817 total
includes taxes & fees
20 Jan - 21 Jan
La Quinta Inn & Suites by Wyndham Houston NW Beltway8/WestRD

DoubleTree by Hilton Houston Intercontinental Airport

DoubleTree by Hilton Houston Intercontinental Airport
4.0 star property
31.5 km from South Main
8.4 out of 10, Very good, (1,002 reviews)
"Clean rooms, friendly staff. Yummy warm cookies upon checkin! "
United States
Amanda
The price is Rp2.201.727
Rp2.576.021 total
includes taxes & fees
30 Jan - 31 Jan
DoubleTree by Hilton Houston Intercontinental Airport

Haven Inn & Suites Downtown Houston

Haven Inn & Suites Downtown Houston
2.5 star property
North Houston, 18.7 km from South Main
9.4 out of 10, Exceptional, (1,002 reviews)
"Better breakfast options. "
United States
Cecilia
Haven Inn & Suites Downtown Houston

Moxy Houston Downtown

Moxy Houston Downtown
3.0 star property
Downtown Houston, 11.2 km from South Main
8.8 out of 10, Excellent, (712 reviews)
"Staff was very pleasant and the rooms were clean."
United States
Elizabeth
The price is Rp1.794.244
Rp2.138.781 total
includes taxes & fees
15 Feb - 16 Feb
Moxy Houston Downtown

Four Points by Sheraton Houston Hobby Airport

Four Points by Sheraton Houston Hobby Airport
3.0 star property
Southeast Houston, 15.3 km from South Main
7.8 out of 10, Good, (1,001 reviews)
"Staff"
United States
Omolara
The price is Rp999.710
Rp1.169.659 total
includes taxes & fees
19 Jan - 20 Jan
Four Points by Sheraton Houston Hobby Airport

WoodSpring Suites Houston Northwest

WoodSpring Suites Houston Northwest
2.5 star property
23.8 km from South Main
7.6 out of 10, Good, (519 reviews)
"Great experience!!"
United States
Bryant
The price is Rp1.029.938
Rp1.184.429 total
includes taxes & fees
19 Jan - 20 Jan
WoodSpring Suites Houston Northwest

Hilton Garden Inn Houston Hobby Airport, TX

Hilton Garden Inn Houston Hobby Airport, TX
3.0 star property
15 km from South Main
8.8 out of 10, Excellent, (1,001 reviews)
"Staff was amazing and attentive. Our room was clean, the amenities were enjoyable. We will be back for sure!"
United States
SAMANTHA
The price is Rp1.547.356
Rp1.810.407 total
includes taxes & fees
24 Jan - 25 Jan
Hilton Garden Inn Houston Hobby Airport, TX

Embassy Suites Houston Downtown

Embassy Suites Houston Downtown
3.5 star property
10.4 km from South Main
9.2 out of 10, Wonderful, (1,004 reviews)
"Staff was courteous at check-in and the room was clean."
United States
Ifeanyi
The price is Rp2.755.621
Rp3.224.078 total
includes taxes & fees
15 Feb - 16 Feb
Embassy Suites Houston Downtown

Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG

Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG
2.5 star property
29.9 km from South Main
8.2 out of 10, Very good, (1,055 reviews)
"Great place to stay overnight. "
United States
Raul
The price is Rp1.198.977
Rp1.402.803 total
includes taxes & fees
30 Jan - 31 Jan
Holiday Inn Express & Suites Houston IAH - Beltway 8 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Main Street Square Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
Where is the best hotel for a stay in South Main?
Based on Expedia customer reviews, Comfort Suites Houston near Medical Center- NRG Stadium is the highest ranked property in South Main. This hotel is a short 10-minute walk from NRG Stadium, and it offers free breakfast and a fitness centre. Other top choices in the neighbourhood include Candlewood Suites Houston Medical Center by IHG and Quality Inn & Suites NRG Park - Medical Center.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 64 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.