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Our top choices for South Main hotels

1. Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (888 reviews)
"This place had"
United States
Marvin
The price is Rp1.087.088
Rp1.271.892 total
includes taxes & fees
2 Aug - 3 Aug
Candlewood Suites Houston Medical Center by IHG

2. Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.0 out of 10, Good, (1,360 reviews)
"Room was clean and the staff was very nice."
United States
Juan
The price is Rp1.541.206
Rp1.803.211 total
includes taxes & fees
3 Aug - 4 Aug
Wyndham Houston near NRG Park/Medical Center

3. Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,006 reviews)
"convenient to medical center"
United States
Mike
The price is Rp1.051.067
Rp1.229.750 total
includes taxes & fees
19 Aug - 20 Aug
Quality Inn & Suites NRG Park - Medical Center

4. Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.8 out of 10, Excellent, (1,001 reviews)
"Very good all around. Very close to the stadium."
Canada
marty
The price is Rp1.572.604
Rp1.839.948 total
includes taxes & fees
21 Aug - 22 Aug
Comfort Suites Houston near Medical Center- NRG Stadium

5. Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,001 reviews)
The price is Rp1.508.052
Rp1.764.420 total
includes taxes & fees
23 Jul - 24 Jul
Wingate Houston near NRG Park/Medical Center

6. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,844 reviews)
"Everything was perfect hotel was so nice & very clean"
United States
Taishiana
The price is Rp2.512.326
Rp2.939.420 total
includes taxes & fees
21 Aug - 22 Aug
Blossom Hotel Houston, Curio Collection by Hilton

7. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,602 reviews)
"Clean room, great breakfast and friendly staff."
United States
Sonya
The price is Rp2.264.018
Rp2.662.940 total
includes taxes & fees
28 Jul - 29 Jul
Hyatt Place Houston Medical Center

8. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.4 out of 10, Very good, (1,531 reviews)
"Nice stay and great staff"
United States
Alelia
The price is Rp1.448.763
Rp1.784.570 total
includes taxes & fees
26 Jul - 27 Jul
Hotel Ylem

9. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,267 reviews)
"Always very friendly and accommodating. Superior transportation support to and from hotel. Excellent breakfast"
United States
Theresa
The price is Rp2.174.621
Rp2.557.790 total
includes taxes & fees
28 Jul - 29 Jul
Hyatt House Houston Medical Center

10. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,164 reviews)
"The customer service is amazing from the valet to the front desk"
United States
Tanasia
The price is Rp3.052.955
Rp3.800.014 total
includes taxes & fees
2 Aug - 3 Aug
The Westin Houston Medical Center/Museum District

11. Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 9.4 km from South Main
9.4 out of 10, Exceptional, (1,483 reviews)
"Staff was so nice! The happy hour was great as well and we were really happy with the property."
United States
Angela
The price is Rp1.684.395
Rp1.970.742 total
includes taxes & fees
3 Aug - 4 Aug
Drury Inn & Suites Houston Near the Galleria

12. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
6.6 km from South Main
8.4 out of 10, Very good, (1,736 reviews)
"Excellent place to stay with family"
United States
Fahad
The price is Rp1.799.825
Rp2.105.796 total
includes taxes & fees
26 Jul - 27 Jul
DoubleTree by Hilton Hotel Houston - Greenway Plaza

13. Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (359 reviews)
"Clean quiet rooms nice breakfast great staff"
United States
Keitha
The price is Rp1.702.495
Rp1.991.918 total
includes taxes & fees
22 Jul - 23 Jul
Best Western Plus Pearland/Houston Medical Center Hotel

14. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
6.5 km from South Main
7.8 out of 10, Good, (1,543 reviews)
"The kitchen staff was wonderful and one of the nicest breakfast I've had at any hotel!"
United States
Christy
The price is Rp1.120.600
Rp1.311.103 total
includes taxes & fees
16 Aug - 17 Aug
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

15. Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.2 out of 10, Wonderful, (164 reviews)
"Clean room & nice location"
United States
Andres
The price is Rp1.021.421
Rp1.194.978 total
includes taxes & fees
31 Jul - 1 Aug
Studio 6 Houston, TX – Pearland/Medical Center

16. Sonesta ES Suites Houston Galleria

Sonesta ES Suites Houston Galleria
3.0 star property
The Galleria, 8.4 km from South Main
8.4 out of 10, Very good, (1,334 reviews)
"The hotel is well located and very comfortable"
United States
Jorge Luis
The price is Rp1.660.381
Rp1.942.636 total
includes taxes & fees
27 Jul - 28 Jul
Sonesta ES Suites Houston Galleria

17. Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
3.0 star property
10.2 km from South Main
9.2 out of 10, Wonderful, (1,112 reviews)
"Staff was great, room clean, good location!"
United States
John
The price is Rp2.116.649
Rp2.476.479 total
includes taxes & fees
11 Aug - 12 Aug
Best Western Plus Downtown Inn & Suites

18. Homewood Suites by Hilton Houston Memorial

Homewood Suites by Hilton Houston Memorial
3.0 star property
16.4 km from South Main
9.6 out of 10, Exceptional, (1,006 reviews)
"Excellent for families. Clean and helpful staff."
United States
Anup Dharia
The price is Rp1.690.846
Rp1.978.290 total
includes taxes & fees
9 Aug - 10 Aug
Homewood Suites by Hilton Houston Memorial

19. Hyatt Place Houston/Galleria

Hyatt Place Houston/Galleria
3.0 star property
8.7 km from South Main
8.8 out of 10, Excellent, (1,547 reviews)
"Excellent stay!!!"
United States
Loukisha
The price is Rp1.812.748
Rp2.132.761 total
includes taxes & fees
7 Aug - 8 Aug
Hyatt Place Houston/Galleria

20. Hyatt Place Houston/Sugar Land

Hyatt Place Houston/Sugar Land
3.0 star property
21.4 km from South Main
8.8 out of 10, Excellent, (1,928 reviews)
"Perfect stay , everything was as expected and smelled amazing"
United States
Raul
The price is Rp2.277.759
Rp2.619.423 total
includes taxes & fees
23 Jul - 24 Jul
Hyatt Place Houston/Sugar Land
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Desk, laptop workspace, iron/ironing board (on request), rollaway beds
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.8
Excellent
1,001 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
888 reviews
View
Premium bedding, pillow-top beds, in-room safe, desk
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.0
Good
1,360 reviews
View
Hypo-allergenic bedding, in-room safe, desk, blackout curtains
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,006 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,001 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Tour the beautiful green spaces, buzzing theater district and professional sports arenas nestled beneath a dramatic cityscape of gleaming skyscrapers.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Looking for sights you might find in a travel guide about South Main? Consider a visit to NRG Park while you're in the neighbourhood.
Where is the best hotel for a stay in South Main?
Based on our traveller data, Wyndham Houston near NRG Park/Medical Center is one of the top choices for your stay in South Main. This hotel is a short 3-minute walk from NRG Park, and it offers a restaurant and an outdoor pool.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 60 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
Popular attractions in South Main include NRG Park. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.