Search Hotels in Santa Fe, Medellin

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31 Dec - 1 Jan
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1 Jan - 2 Jan
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2 Jan - 4 Jan
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9 Jan - 11 Jan

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Our top choices for Santa Fe hotels

Front of property
Hotel Boutique Olaya 54

Hotel Boutique Olaya 54

Hotel Boutique Olaya 54
3.0 star property
Santa Fe
10.0 out of 10, Exceptional, (1)
"Convenient and cozy . Per friendly was a plus ! "
United States
Alfonso
The price is Rp1.189.969
Rp1.189.969 total
30 Jan - 31 Jan 2026
Hotel Boutique Olaya 54
Breakfast area
Ayenda Casa San Pablo

Ayenda Casa San Pablo

Ayenda Casa San Pablo
2.5 star property
Santa Fe
8.0 out of 10, Very good, (7)
"Room was very small, the bathroom tiny and uncomfortable to navigate. Facilities were clean and the staff courteous."
United States
Jose
The price is Rp926.911
Rp926.911 total
30 Jan - 31 Jan 2026
Ayenda Casa San Pablo
Restaurant
Hotel Attic 33

Hotel Attic 33

Hotel Attic 33
3.0 star property
Laureles, 1.9 km from Santa Fe
9.6 out of 10, Exceptional, (16)
"Clean room, staff, love the place."
United States
Luis
The price is Rp822.892
Rp822.892 total
11 Jan - 12 Jan 2026
Hotel Attic 33
Presidential Suite | Premium bedding, minibar, in-room safe, blackout curtains
Hotel Once22

Hotel Once22

Hotel Once22
3.0 star property
8.9 km from Santa Fe
9.6 out of 10, Exceptional, (32)
"Great stay as usual, wonderful service from check-in to check-out"
United States
Al
The price is Rp1.007.607
Rp1.007.607 total
6 Jan - 7 Jan 2026
Hotel Once22
Terrace/patio
Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta

Fairfield by Marriott Medellin Sabaneta
3.5 star property
8.4 km from Santa Fe
9.4 out of 10, Exceptional, (244)
"great location "
United States
Juliana
The price is Rp1.207.512
Rp1.207.512 total
9 Jan - 10 Jan 2026
Fairfield by Marriott Medellin Sabaneta
Garden
4 Sur Hotel

4 Sur Hotel

4 Sur Hotel
3.0 star property
Guayabal, 1.8 km from Santa Fe
9.4 out of 10, Exceptional, (203)
"It was very comfortable. "
United States
Alejandro
The price is Rp1.451.701
Rp1.505.006 total
8 Jan - 9 Jan 2026
4 Sur Hotel
Restaurant
ibis budget Medellín Itagüí Metro

ibis budget Medellín Itagüí Metro

ibis budget Medellín Itagüí Metro
3.0 star property
6.9 km from Santa Fe
9.0 out of 10, Wonderful, (404)
"Great location with clean rooms!"
United States
Camila
The price is Rp795.129
Rp795.129 total
1 Jan - 2 Jan 2026
ibis budget Medellín Itagüí Metro
Lobby sitting area
Hotel Nutibara

Hotel Nutibara

Hotel Nutibara
3.0 star property
La Candelaria, 3.8 km from Santa Fe
7.4 out of 10, Good, (538)
"Good, staff very friendley. "
United States
Robert
The price is Rp1.427.233
Rp1.427.233 total
29 Jan - 30 Jan 2026
Hotel Nutibara
Reception
The Host Medellin Only Adults

The Host Medellin Only Adults

The Host Medellin Only Adults
3.0 star property
Astorga, 1.8 km from Santa Fe
9.8 out of 10, Exceptional, (14)
"Great ambience and room, excellent breakfast "
United States
Shailendra
The price is Rp2.494.661
Rp2.494.661 total
2 Jan - 3 Jan 2026
The Host Medellin Only Adults
Design Studio Suite, 1 Queen Bed, Non Smoking, Kitchenette | Living area | 43-inch Smart TV with cable channels, TV
Indie Universe Creative Hotel

Indie Universe Creative Hotel

Indie Universe Creative Hotel
2.5 star property
Laureles, 2.4 km from Santa Fe
8.4 out of 10, Very good, (149)
"I love the designs of the room and views."
United States
Giovanni Blu
Indie Universe Creative Hotel
Outdoor pool
Los Patios Cool Living

Los Patios Cool Living

Los Patios Cool Living
3.0 star property
Laureles, 2 km from Santa Fe
9.4 out of 10, Exceptional, (436)
"Great hotel, with very helpful and friendly staff! Highly recommended! "
United States
Sean
Los Patios Cool Living
Panoramic Loft, 1 King Bed | Down duvets, in-room safe, desk, laptop workspace
Firenze Lofts

Firenze Lofts

Firenze Lofts
3.0 star property
La América, 4 km from Santa Fe
9.6 out of 10, Exceptional, (383)
"Clean room and staff was amazing."
United States
Janny
Firenze Lofts
Exterior
Nakúa Stay + Work

Nakúa Stay + Work

Nakúa Stay + Work
2.5 star property
El Poblado, 2.4 km from Santa Fe
9.4 out of 10, Exceptional, (117)
"Everything was great . Clean "
United States
Gilberto
The price is Rp1.224.063
Rp1.224.063 total
2 Jan - 3 Jan 2026
Nakúa Stay + Work
Front of property
Hotel Lleras 10

Hotel Lleras 10

Hotel Lleras 10
3.0 star property
Zona Rosa, 2 km from Santa Fe
8.2 out of 10, Very good, (335)
"Great hotel , staff is great "
United States
Luis
Hotel Lleras 10
Sun deck
The Morgana Poblado Suites Hotel

The Morgana Poblado Suites Hotel

The Morgana Poblado Suites Hotel
3.5 star property
Buenos Aires, 2.3 km from Santa Fe
8.8 out of 10, Excellent, (864)
"Staff always super nice and very approachable"
United States
Hector
The Morgana Poblado Suites Hotel
Outdoor pool
La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin

La Quinta by Wyndham Medellin
3.5 star property
San Diego, 1.9 km from Santa Fe
8.8 out of 10, Excellent, (1003)
"Breakfast, clean room and room service amazing!"
United States
Lyandra Jiliénne
The price is Rp1.411.280
Rp1.411.280 total
14 Jan - 15 Jan 2026
La Quinta by Wyndham Medellin
Deluxe Double Room, City View | Minibar, in-room safe, individually decorated, individually furnished
Moa Select

Moa Select

Moa Select
3.0 star property
Belen, 2.5 km from Santa Fe
9.2 out of 10, Wonderful, (204)
"Clean and pretty rooms and excellent breakfast. "
United States
ALYNEL
The price is Rp810.874
Rp810.874 total
20 Jan - 21 Jan 2026
Moa Select
Minibar, in-room safe, desk, laptop workspace
Hotel Madeiro

Hotel Madeiro

Hotel Madeiro
3.0 star property
Zona Rosa, 2.2 km from Santa Fe
8.4 out of 10, Very good, (246)
"Incredible location and my time at Madeiro was very nice. I recommend everyone to stay here. "
United States
David
Hotel Madeiro
Deluxe Double Room | In-room safe, blackout curtains, iron/ironing board
Hunters By Jalo

Hunters By Jalo

Hunters By Jalo
3.0 star property
Provenza, 2.3 km from Santa Fe
9.0 out of 10, Wonderful, (224)
"Really nice hotel! "
United States
IBRAHIM
The price is Rp1.001.219
Rp1.001.219 total
8 Jan - 9 Jan 2026
Hunters By Jalo
Restaurant
Nomada Hotel Origen

Nomada Hotel Origen

Nomada Hotel Origen
3.0 star property
Manila, 1.4 km from Santa Fe
9.4 out of 10, Exceptional, (100)
"Lovely place, great service, awesome food!"
United States
Alejandro
The price is Rp1.143.830
Rp1.143.830 total
28 Jan - 29 Jan 2026
Nomada Hotel Origen
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Fe

Find the best Santa Fe areas for the activities you enjoy most.
El Castillo Museum showing heritage architecture and château or palace

El Poblado

El Poblado is highly notable for its popular shops, and you might want to visit top sights like Golden Mile and Oviedo Shopping Center. See more of Medellín by jumping on the metro at Poblado Station or Aguacatala Station.

Rock of Guatape featuring a house, mist or fog and tranquil scenes

Laureles

Laureles is known for its ample dining options, and you can make a stop by Unicentro Shopping Center and Belén Andrés Escobar Sports Complex while in the area.

Provenza

If you're looking for some top things to see and do in Provenza and surrounding area, you can visit Golden Mile and Oviedo Shopping Center.

Laureles - Estadio

While you're in Laureles - Estadio, take in top sights like Atanasio Giradot Stadium or Unicentro Shopping Center, and hop on the metro to see more of the city at Estadio Station or Suramericana Station.

Zona Rosa

When in Zona Rosa, you can plan a visit to Golden Mile and Oviedo Shopping Center, some noteworthy sights in the nearby area.

Top Santa Fe Hotel Reviews

Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

10/10 Excellent
"Everything was perfect! And the service desk guys Juan David and Angelica was great!"
William 4-night trip
Posted 3 days ago
Calle Flora Hotel by Jalo

Frequently asked questions

What's it like in Santa Fe?
You'll be sure to have fun exploring Medellín's Santa Fe neighbourhood. Consider a visit to Santa Fe Zoological Park as part of your Santa Fe travel plans.
How many hotels will I be able to find in Santa Fe?
If you're searching for places to stay in Medellín, choose from one of Expedia's 12 hotels and other accommodation options in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes, you'll find most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Santa Fe.
What is there to do around this Medellín neighbourhood?
Santa Fe Zoological Park is an attraction you might want to check out while you're in Santa Fe. While you're out sightseeing, Medellin's Museum of Modern Art and Monterrey Comercial Mall are a couple of additional sights to visit in Medellín.