The Best Hotels Closest to Florida Keys National Marine Sanctuary in Key West - 2026 Updated Prices

Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds

Almond Tree Inn Hotel - Adults Only

Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary

Jimmy

Rp4.877.154 total

includes taxes & fees

1 Jun - 2 Jun

Key West Villas

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Jennifer

Rp3.965.112 total

includes taxes & fees

4 Jun - 5 Jun

The Gardens Hotel

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Markus

Rp5.408.723 total

includes taxes & fees

28 Jun - 29 Jun

Orchid Key Inn - Adults Only

Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary

Michael

Rp5.478.628 total

includes taxes & fees

3 Jun - 4 Jun

Queen with Pool View | Minibar, in-room safe, individually decorated, individually furnished

Simonton Court Historic Inn & Cottages

Historic Seaport, 1 km from Florida Keys National Marine Sanctuary

Olha

Rp3.600.787 total

includes taxes & fees

1 Jun - 2 Jun

The Marquesa Hotel

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Julian

Rp7.221.778 total

includes taxes & fees

1 Jun - 2 Jun

Douglas House - Adults Only

Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary

Matthew

Rp3.621.137 total

includes taxes & fees

3 Jun - 4 Jun

The Conch House Heritage Inn

Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary

Lucy

Rp4.779.591 total

includes taxes & fees

9 Jun - 10 Jun

11 Gecko's Garden - Adults Only | Premium bedding, pillow-top beds, individually decorated

Tropical Inn

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

Akhenaton

Rp3.843.700 total

includes taxes & fees

7 Jun - 8 Jun

Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary

Elizabeth

Rp7.825.173 total

includes taxes & fees

21 Jun - 22 Jun

Coco Plum Inn

Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary

Brinkley

Rp4.074.365 total

includes taxes & fees

2 Jun - 3 Jun

Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary

Troy

Rp3.408.285 total

includes taxes & fees

2 Jun - 3 Jun

L'Habitation Guest House

Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary

Megan

Rp2.516.751 total

includes taxes & fees

2 Jun - 3 Jun

Duval House

Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary

gerald

Rp3.180.584 total

includes taxes & fees

3 Jun - 4 Jun

Marrero's Guest Mansion

Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary

Robert

Rp5.009.005 total

includes taxes & fees

4 Jun - 5 Jun

Santa Maria Suites

Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary

Jill

Rp7.422.850 total

includes taxes & fees

21 Jun - 22 Jun

Superior Studio Suite, 1 King Bed with Sofa bed, Accessible, Refrigerator & Microwave | Free WiFi, bed sheets

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary

Annette

Rp4.318.977 total

includes taxes & fees

3 Jun - 4 Jun

Southernmost House - Adult Exclusive

Uptown - Upper Duval, 1.2 km from Florida Keys National Marine Sanctuary

BOBBY J.

Rp6.109.268 total

includes taxes & fees

28 Jun - 29 Jun

3 outdoor pools, a heated pool, pool loungers

Ambrosia Key West

Old Town Key West, 1 km from Florida Keys National Marine Sanctuary

Lori

Rp4.970.710 total

includes taxes & fees

1 Jun - 2 Jun

The Grand Guesthouse

Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary

Jacqueline

Rp3.669.990 total

includes taxes & fees

1 Jun - 2 Jun

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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property	Property class	Guest rating
Almond Tree Inn Hotel - Adults Only	3.5 star property	10.0 Exceptional 1,001 reviews	View
Key West Villas	3.5 star property	9.8 Exceptional 261 reviews	View
The Gardens Hotel	4.0 star property	9.8 Exceptional 1,002 reviews	View
Orchid Key Inn - Adults Only	3.5 star property	9.8 Exceptional 1,003 reviews	View
Simonton Court Historic Inn & Cottages	2.5 star property	9.8 Exceptional 969 reviews	View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

10/10 Excellent

"Our first time at the opal and our first time at Key West enjoyed the service and the location would go again"

Southwinds Motel

6/10 Okay

"This place is fine to rest your head if you want to be in Old Town on a budget. But even budget prices are way too high for what is essentially a very dated motel. Our room wasn’t ready until 4, but we were allowed to leave our bags unsecured under a table in the lobby until then. The air conditioner thudded loudly all night against the wall because it was improperly installed, and the bathroom was massive with a ton of dead space around the narrow prison shower and tiny vanity. Everything shabby. The small fridge, TV, and coffee maker were all stacked on top of each other and shared the same outlet. When the power went out in the middle of the afternoon, the staff did not seem particularly concerned. Breakfast was included, but nothing special—muffins squashed in plastic wrap, weak coffee with grounds floating in it served in flimsy styrofoam cups. Yogurt. Bagels. They charged extra for amenities—use of the small pool in the parking lot and towels for the beach—that did not seem to be worth the extra $65. Housekeeping only comes every third day. Beggars can’t be choosers. But if you’re not desperate or on a tight budget, look elsewhere."

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

4.4/5 (128 reviews)

Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.

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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?

Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1545 hotels and other accommodation options you'll find within a mile.

What's the best place to stay close to Florida Keys National Marine Sanctuary?

Southernmost Beach Resort and Guesthouses is one of the top choices for your stay based on our traveller data, and this hotel offers 3 outdoor pools and a full-service spa. It's located just a short 0.7 mi (1.1 km) from Florida Keys National Marine Sanctuary. Other good choices close by include La Concha Key West, Autograph Collection and Opal Key Resort & Marina, Key West.

How many hotels will I find near Florida Keys National Marine Sanctuary?

Expedia has 1545 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.

If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.

What can I see and do near Florida Keys National Marine Sanctuary?

Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society and Red Barn Theater if you're interested in local theatre.

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Our top choices for Florida Keys National Marine Sanctuary hotels

Almond Tree Inn Hotel - Adults Only

Key West Villas

The Gardens Hotel

Orchid Key Inn - Adults Only

Simonton Court Historic Inn & Cottages

The Marquesa Hotel

Douglas House - Adults Only

The Conch House Heritage Inn

Tropical Inn

H2O Suites - Adults Only

Coco Plum Inn

Island City House Hotel

L'Habitation Guest House

Duval House

Marrero's Guest Mansion

Santa Maria Suites

Alexanders Guesthouse - Adult Exclusive, LGBTQ Friendly

Southernmost House - Adult Exclusive

Ambrosia Key West

The Grand Guesthouse

Compare popular hotels close to Florida Keys National Marine Sanctuary

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

Frequently asked questions