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7 Nov - 8 Nov
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8 Nov - 9 Nov
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13 Nov - 15 Nov
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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.4 out of 10, Very good, (1,960 reviews)
"Good place to stay for work."
United States
Renato
The price is Rp2.351.570
Rp2.674.911 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
A hotel room with a kitchenette, dining area, and a ceiling fan.

2. Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1,002 reviews)
"clean room nice place to stay"
Mexico
Anonymous traveller
The price is Rp1.965.370
Rp2.235.620 total
includes taxes & fees
6 Dec - 7 Dec
Quality Suites San Diego Otay Mesa
A hotel room with a large bed, a desk with a chair, a nightstand, a mirror, and a blue-striped carpet.

3. Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very good, (2,039 reviews)
"Me and my husband loved it we tried different ones and this one is one of the best from now on is going to be our favorite to stay,very clean and breakfast was so good so many options for breakfast"
United States
Edna
The price is Rp1.982.691
Rp2.184.826 total
includes taxes & fees
6 Dec - 7 Dec
Best Western Chula Vista/Otay Valley Hotel
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.

4. Ayres Hotel San Diego South - Chula Vista

Ayres Hotel San Diego South - Chula Vista
3.0 star property
6.5 km from Otay Mesa
9.8 out of 10, Exceptional, (1,029 reviews)
"I was very impressed with this hotel. The rooms were comfortable and modern and the staff was warm and welcoming."
United States
Rosemary
The price is Rp3.076.939
Rp3.390.602 total
includes taxes & fees
29 Nov - 30 Nov
Ayres Hotel San Diego South - Chula Vista
A compact hotel room with a kitchenette, a bed, a small seating area, and a window providing natural light.

5. Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,651 reviews)
"Great stay"
United States
Daniel
The price is Rp2.802.710
Rp3.082.981 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express San Diego South - Chula Vista by IHG
View from property

6. SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (816 reviews)
"Great hotel"
United States
leslie
The price is Rp3.718.194
Rp4.097.264 total
includes taxes & fees
17 Nov - 18 Nov
SpringHill Suites by Marriott Chula Vista Eastlake
A hotel room with two beds, a television, a desk, and a dresser.

7. La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,792 reviews)
"Clean room , friendly staff , always helpful, breakfast good , always great to return"
United States
Luis
The price is Rp1.860.454
Rp2.046.499 total
includes taxes & fees
22 Nov - 23 Nov
La Quinta Inn by Wyndham San Diego Chula Vista
A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

8. Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.4 out of 10, Very good, (1,727 reviews)
"The breakfast and the staff were great!"
United States
Xochitl
The price is Rp1.875.829
Rp2.067.164 total
includes taxes & fees
29 Nov - 30 Nov
Comfort Inn Chula Vista San Diego South
A motel with a sign indicating amenities like Wi-Fi, TV, and pool.

9. Valli Hi Motel

Valli Hi Motel
2.0 star property
7.9 km from Otay Mesa
8.2 out of 10, Very good, (1,167 reviews)
"Great stay and good room."
United States
Christian
The price is Rp1.465.209
Rp1.669.532 total
includes taxes & fees
8 Nov - 9 Nov
Valli Hi Motel
A swimming pool with palm trees and a mountain in the background.

10. Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (2,215 reviews)
"Great stay!"
United States
Kimberly
The price is Rp1.645.195
Rp2.026.872 total
includes taxes & fees
9 Nov - 10 Nov
Sycuan Casino Resort
A modern living room with a stone fireplace, sofas, a coffee table, and a view of the upper floor.

11. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (4,225 reviews)
"Great property, friendly staff and a restaurant with good food and live music next door. Had an excellent time!"
United States
Candas
The price is Rp2.424.977
Rp2.672.203 total
includes taxes & fees
29 Nov - 30 Nov
Best Western Plus Marina Gateway Hotel
A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

12. Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.8 out of 10, Excellent, (1,575 reviews)
"Great stay"
United States
fannie
The price is Rp2.013.033
Rp2.218.262 total
includes taxes & fees
6 Dec - 7 Dec
Hercor Hotel - Urban Boutique
A spacious lobby with a fireplace, wooden furniture, and a chandelier.

13. Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
8.8 out of 10, Excellent, (1,421 reviews)
"Great service from the staff!"
United States
Erika
The price is Rp1.894.280
Rp2.154.744 total
includes taxes & fees
22 Nov - 23 Nov
Best Western Americana Inn
A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

14. The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,206 reviews)
"Solid place to stay"
United States
Neal
The price is Rp1.675.297
Rp1.938.235 total
includes taxes & fees
6 Dec - 7 Dec
The Rambler Hotel
A room with two teal armchairs, a small round table with a lamp, and a large cityscape painting on the wall.

15. SureStay Hotel by Best Western Chula Vista San Diego Bay

SureStay Hotel by Best Western Chula Vista San Diego Bay
3.0 star property
14.7 km from Otay Mesa
8.0 out of 10, Very good, (2,020 reviews)
"A good hotel, with a good location at a very good price, has a reasonable breakfast."
Brazil
Sergio
The price is Rp1.383.454
Rp1.524.497 total
includes taxes & fees
16 Nov - 17 Nov
SureStay Hotel by Best Western Chula Vista San Diego Bay
An outdoor seating area with a fire feature, string lights, and a view of the city skyline.

16. Loews Coronado Bay Resort

Loews Coronado Bay Resort
4.0 star property
17.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1,166 reviews)
"Lovely place to stay, beautiful scenery. The only downside is everything is far away- gas station, restaurants, you have to UBER or have a rental car to travel for amenities outside of what the resort offers."
United States
Josh
The price is Rp3.521.024
Rp4.867.667 total
includes taxes & fees
29 Nov - 30 Nov
Loews Coronado Bay Resort
A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

17. Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.4 out of 10, Good, (2,455 reviews)
"A modest and clean hotel, recommended, with reasonable prices."
United States
AHMAD
The price is Rp1.237.939
Rp1.361.733 total
includes taxes & fees
8 Nov - 9 Nov
Hotel Palmeras Chula Vista
A high-rise building complex with multiple floors, large windows, and a waterfront view.

18. Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 24.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,890 reviews)
"Love this hotel super nice"
United States
Sarah
The price is Rp3.239.740
Rp4.741.986 total
includes taxes & fees
9 Nov - 10 Nov
Manchester Grand Hyatt San Diego
A hotel room with two beds, a desk, and a chair.

19. Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.6 out of 10, Good, (1,192 reviews)
"Great stay for a stay !"
United States
Monserrat
The price is Rp1.306.425
Rp1.439.689 total
includes taxes & fees
16 Nov - 17 Nov
Howard Johnson by Wyndham National City/San Diego South
A resort with two-story buildings, balconies, and a pool area.

20. Humphreys Half Moon Inn

Humphreys Half Moon Inn
3.5 star property
29.3 km from Otay Mesa
9.2 out of 10, Wonderful, (3,161 reviews)
"Best place to stay in San Diego and I will be coming back"
United States
Ronald
The price is Rp2.785.706
Rp3.563.895 total
includes taxes & fees
23 Nov - 24 Nov
Humphreys Half Moon Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Otay Mesa

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
8.4
Very good
1,960 reviews
View
A hotel room with a kitchenette, dining area, and a ceiling fan.
Quality Suites San Diego Otay Mesa
2.5 star property
7.2
Good
1,002 reviews
View
A spacious lobby with a fireplace, wooden furniture, and a chandelier.
Best Western Americana Inn
2.5 star property
8.8
Excellent
1,421 reviews
View
A spacious lobby with a modern design, featuring a large seating area, a reception desk, and large windows offering views of the city.
Ayres Hotel San Diego South - Chula Vista
3.0 star property
9.8
Exceptional
1,029 reviews
View
A modern living room with a large window, a fireplace, and a kitchen area.
Rodeway Inn San Diego South San Ysidro Border
2.0 star property
8.0
Very good
318 reviews
View

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Top Otay Mesa Hotel Reviews

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Otay Mesa

10/10 Excellent

Amazing very clean nice
United Kingdom
Umit
Reviewed August 3, 2025
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Frequently Asked Questions

What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveller data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.