Otay Mesa West Travel Guide
San Diego
Visit Otay Mesa West
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and entertainment choices.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
USS Midway Museum with Direct-to-Gate
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
San Diego: Museum of Illusions Entry Ticket
City Cruises San Diego: Signature Dinner Cruise
San Diego Whale Watching & Dolphin Cruise
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
Top hotels in Otay Mesa West
Bay Club Hotel & Marina
I love the Bayclub Hotel and Marina. The staff is helpful and friendly. The views are amazing. The restaurant is very good and they have happy hour from 2:00-6:00 each day. I absolutely enjoy the server Miriam, who works at breakfast time. She is always so friendly, so polite, and we will go out ...
Reviewed on 3 Feb 2026
Hard Rock Hotel San Diego
Very clean hotel. I was always seeing someone cleaning.
Reviewed on 2 Feb 2026
Paradise Point Resort & Spa
Always a good time
Reviewed on 30 Jan 2026
The DEXTRO Little Italy, BW Premier Collection
Very clean, comfy and spacious room. The staff was friendly and the location was good, if you’re looking to be close to Little Italy restaurants.
Reviewed on 3 Feb 2026
San Diego Mission Bay Resort
Great room, great amenities, the resort was so nice.
Reviewed on 21 Jan 2026
The Sofia Hotel
Excellent location! The staff was friendly and the hotel is lovely. Our room was nice and spacious, and the bed was very comfortable. I would not hesitate to stay here again in the future.
Reviewed on 29 Jan 2026
Other neighbourhoods around Otay Mesa West
East Village
Travellers choose East Village for its great bars. Hop aboard the metro at City College Trolley Station or Park and Market Trolley Station and check out top sights like Petco Park.
Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.
Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
