Serra Mesa Travel Guide
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's entertainment choices and fascinating museums.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Things to do
USS Midway Museum with Direct-to-Gate
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
LEGOLAND® California Resort
San Diego: Museum of Illusions Entry Ticket
City Cruises San Diego: Signature Dinner Cruise
San Diego Whale Watching & Dolphin Cruise
Top hotels in Serra Mesa
Paradise Point Resort & Spa
The room and view was great, it was very easy to request towels etc. the staff were very friendly.
Reviewed on 17 Feb 2026
Hard Rock Hotel San Diego
Room was perfect
Reviewed on 17 Feb 2026
The DEXTRO Little Italy, BW Premier Collection
The first room they put us in was not what we had paid for which was supposed to be a king bed on top floor with city views. Instead they offered us a two double beds on the freeway side which was like sleeping on the freeway…almost. In the morning I tried to take a shower and only the hot and boiling ...
Reviewed on 17 Feb 2026
The Sofia Hotel
Good
Reviewed on 18 Feb 2026
Wyndham San Diego Bayside
Perfect location! Very clean and the staff were wonderful! The bay view was gorgeous.
Reviewed on 18 Feb 2026
Days Inn by Wyndham San Diego Hotel Circle
Room was clean ,beds are good
Reviewed on 17 Feb 2026
Other neighbourhoods around Serra Mesa
Mission Valley
Known for its stunning beaches and popular shops, there's plenty to explore in Mission Valley. Check out top attractions like Mission Valley Mall and Fashion Valley Mall, and jump on the metro at Hazard Center Station or Mission Valley Center Station to see more of the city.
North Park
North Park is well liked for its restaurants, and you can visit sights like San Diego Zoo and San Diego Natural History Museum if you have time to explore the area.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Old Town San Diego
The abundant dining options and seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Little Italy
Visitors to Little Italy love its captivating waterfront views, and you can check out Maritime Museum of San Diego and San Diego Bay. If you want to see more in the area, you can get around town on the metro at County Center - Little Italy Station.
