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18 Dec - 19 Dec
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19 Dec - 20 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Sant' Ambrogio hotels

Lobby lounge
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
5.0 star property
Sant' Ambrogio
10.0 out of 10, Exceptional, (13)
"This hotel was quite the find! The staff was amazing, attentive, respectful. The amenities, attention to detail, experience was amazing! We will definitely be back."
United States
Nicole
The price is Rp8.022.701
Rp9.138.769 total
includes taxes & fees
12 Jan - 13 Jan 2026
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
Rooftop terrace
Appartamento Puccini

Appartamento Puccini

Appartamento Puccini
Sant' Ambrogio
7.8 out of 10, Good, (76)
"The apartment is located perfectly"
Germany
Thomas
Appartamento Puccini
Apartment, 4 Bedrooms | Terrace/patio
Pilastri Garden by Mmega

Pilastri Garden by Mmega

Pilastri Garden by Mmega
Sant' Ambrogio
6.0 out of 10, (2)
"Overall the property was good for the night we had! Great location. Accommodated the people we had. It was quiet "
United States
Sara
Pilastri Garden by Mmega
Premium Apartment | Terrace/patio
Ciompi Prestige by Mmega

Ciompi Prestige by Mmega

Ciompi Prestige by Mmega
Sant' Ambrogio
9.0 out of 10, Wonderful, (2)
The price is Rp2.484.936
Rp4.928.719 total
includes taxes & fees
18 Jan - 19 Jan 2026
Ciompi Prestige by Mmega
Deluxe Villa | Minibar, individually decorated, individually furnished, desk
Villa Tortorelli

Villa Tortorelli

Villa Tortorelli
Sant' Ambrogio
9.6 out of 10, Exceptional, (66)
"Beautiful property! Loved our stay here! "
United States
Olga
Villa Tortorelli
Comfort Apartment, 1 Bedroom, Non Smoking | Living area | Flat-screen TV
Santa Croce Place by Mmega

Santa Croce Place by Mmega

Santa Croce Place by Mmega
Sant' Ambrogio
6.8 out of 10, (5)
"The apartment was not kept well. Consumables like sugar, detergent etc. kept under lock and key. Mosquitoes were a hassle. The bathroom was very tiny. The bedroom is next to the road, so was very noisy. Although it is located at an excellent location."
India
Sachit
Santa Croce Place by Mmega
City view
Iris Apartments by Mmega

Iris Apartments by Mmega

Iris Apartments by Mmega
Sant' Ambrogio
7.8 out of 10, Good, (12)
"Excellent location bit a bit noisy at night."
United States
Stephen
The price is Rp1.495.483
Rp3.449.251 total
includes taxes & fees
19 Dec - 20 Dec
Iris Apartments by Mmega
Deluxe Quadruple Room | Free WiFi
Residenza d'Epoca White Room

Residenza d'Epoca White Room

Residenza d'Epoca White Room
Sant' Ambrogio
7.4 out of 10, Good, (63)
"LOVED this place! It’s huge, cute, clean, centrally located, and has a super nice bathroom. Also has your own A/C unit which was awesome! Highly recommend especially for the price."
United States
Amelia
Residenza d'Epoca White Room
40-inch flat-screen TV with satellite channels
Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca

Dimora del Cardinale - Residenza d'epoca
Sant' Ambrogio
9.8 out of 10, Exceptional, (56)
"We had an easy check-in. Friendly staff welcomed us and we settled in quickly so we could enjoy the sites. We walked to all tours and restaurants. The restaurant next door was so good, we ate their twice! The property is well located to everything - food, shopping and more!"
United States
Stacey
The price is Rp1.612.620
Rp2.009.156 total
includes taxes & fees
21 Dec - 22 Dec
Dimora del Cardinale - Residenza d'epoca
Apartment, 2 Bedrooms | 2 bedrooms, free WiFi, bed sheets
Borgo Pinti Cozy Flat 

Borgo Pinti Cozy Flat 

Borgo Pinti Cozy Flat 
Sant' Ambrogio
7.4 out of 10, Good, (3)
"Excellent property beyond our expectations. After a stressful day of traveling internationally, the key and entry taxed us. The key continued to be an issue for us (skeleton key with 4 locks). But otherwise, it's location and the property itself, awesome!"
United States
Stephanie
Borgo Pinti Cozy Flat 
Interior detail
Alfieri9

Alfieri9

Alfieri9
3.0 star property
Sant' Ambrogio
9.6 out of 10, Exceptional, (158)
"Hotel was in a nice quiet neighborhood, but still only a short walk to main attractions. The breakfast was excellent. Staff interactions were good."
United States
Colin
Alfieri9
Presidential Suite, 1 Bedroom, Hot Tub, City View | 1 bedroom, premium bedding, down duvets, desk
Palazzo dei Ciompi Suites

Palazzo dei Ciompi Suites

Palazzo dei Ciompi Suites
Sant' Ambrogio
7.6 out of 10, Good, (392)
"worst customer service and guest support I have had ever experienced "
United States
Eduard
Palazzo dei Ciompi Suites
Garden
Locanda Orchidea - B&B

Locanda Orchidea - B&B

Locanda Orchidea - B&B
Sant' Ambrogio
9.2 out of 10, Wonderful, (233)
"Perfect location, superb room, + wonderful staff - a brilliant stay all round! "
United Kingdom
TARA
Locanda Orchidea - B&B
Comfort Apartment | Living area | 32-inch flat-screen TV with digital channels
Don Giovanni by Mmega

Don Giovanni by Mmega

Don Giovanni by Mmega
Sant' Ambrogio
9.0 out of 10, Wonderful, (7)
"Perfect location Very clean Nicely appointed"
United States
Luanne
Don Giovanni by Mmega
Interior entrance
Hotel D'Azeglio

Hotel D'Azeglio

Hotel D'Azeglio
2.0 star property
Sant' Ambrogio
7.8 out of 10, Good, (340)
"The place was walking distance very clean and quiet stuff very friendly a plus including breakfast "
United States
Beatriz
The price is Rp864.640
Rp1.127.603 total
includes taxes & fees
21 Dec - 22 Dec
Hotel D'Azeglio
Bar (on property)
Hotel Villa Liana

Hotel Villa Liana

Hotel Villa Liana
3.0 star property
Sant' Ambrogio
8.6 out of 10, Excellent, (342)
"Within reasonable walking distance of center of town, beautiful room with on site parking."
United States
Terry
Hotel Villa Liana
Interior entrance
Hotel Bavaria

Hotel Bavaria

Hotel Bavaria
1.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (408)
"Hermes was very helpful on how to get around the city. He recommended a place to eat. We loved it so much that we went twice. "
United States
Juan
The price is Rp1.184.957
Rp1.440.658 total
includes taxes & fees
18 Jan - 19 Jan 2026
Hotel Bavaria
Restaurant
Hotel Bodoni

Hotel Bodoni

Hotel Bodoni
2.0 star property
Sant' Ambrogio
8.2 out of 10, Very good, (792)
"Nice people and convenient location!!!!"
United States
julio
The price is Rp1.251.544
Rp1.553.198 total
includes taxes & fees
7 Jan - 8 Jan 2026
Hotel Bodoni
Garden
Hotel Regency

Hotel Regency

Hotel Regency
5.0 star property
Sant' Ambrogio
9.4 out of 10, Exceptional, (442)
"Amazing stay as always. Beautiful hotel but the staff make it great. Feels like a home away from home. Perfect location that is easily walkable everywhere in the historic center."
United States
Aaron
The price is Rp4.628.218
Rp5.404.817 total
includes taxes & fees
22 Dec - 23 Dec
Hotel Regency
View from property
B&B di Piazza del Duomo

B&B di Piazza del Duomo

B&B di Piazza del Duomo
Sant' Ambrogio
9.2 out of 10, Wonderful, (245)
"great location."
Australia
Ankur
The price is Rp1.672.247
Rp2.074.804 total
includes taxes & fees
22 Dec - 23 Dec
B&B di Piazza del Duomo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Via de' Calzaiuoli or Giotto's Campanile while you're exploring the neighbourhood.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Sant' Ambrogio Hotel Reviews

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World

10/10 Excellent
"Everything was wonderful. If I had a criticism it would be that the breakfast room was too cold. But that would hardly prevent us from visiting again!"
Jade 3-night trip
Posted 2 weeks ago
The James Suite Hotel Firenze 1564 - Small Luxury Hotels of the World
Hotel Villa Liana

Hotel Villa Liana

10/10 Excellent
"Great staff. very friendly. "
Pedro 1-night trip
Posted 2 months ago
Hotel Villa Liana

Frequently asked questions

What's it like in Sant' Ambrogio?
Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio as part of your Sant' Ambrogio travel plans.
What's a favourite hotel to stay in Sant' Ambrogio?
Based on Expedia customer reviews, Alfieri9 is the highest ranked property in Sant' Ambrogio. This hotel is a short 15-minute walk from Piazza del Duomo, and it offers free WiFi and valet parking. Other favourite options in the area include B&B di Piazza del Duomo and Hotel Regency.
How many hotels can I expect to find in Sant' Ambrogio?
If you're searching for places to stay in Florence, Expedia has something to meet your needs with 515 Sant' Ambrogio hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.
What is there to do around this Florence neighbourhood?
Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Piazza Massimo D'Azeglio and Mercato di Sant'Ambrogio are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Sant' Ambrogio include Jewish Museum, FiesoleBike Day Tours and Galleria d'Arte Civico69. When you're sightseeing in Florence, Teatro della Pergola and Casa Buonarroti are also worth a stop.