A grand church interior with high vaulted ceilings, large columns, and a central altar.

Search Hotels in Santo Spirito, Florence

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santo Spirito hotels

1. Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (711 reviews)
"We had a wonderful stay - the property was beautiful, breakfast was great, and the staff were SO helpful and accommodating. I would recommend this hotel to anyone."
Canada
CHRISTINE
The price is Rp2.579.081
Rp3.128.560 total
includes taxes & fees
24 Aug - 25 Aug
Hotel Horto Convento

2. Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1,157 reviews)
"We loved it!"
United States
Beatriz
The price is Rp2.198.763
Rp2.710.211 total
includes taxes & fees
22 Aug - 23 Aug
Palazzo Mannaioni Suites

3. 1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (202 reviews)
"We had an amazing stay at 1900 Artevita. Friendly staff and very convenient location with close bus stop and comfortable walk to city centre"
Canada
Miket
The price is Rp1.175.752
Rp1.543.245 total
includes taxes & fees
23 Aug - 24 Aug
1900 Artevita

4. UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze
4.0 star property
Santo Spirito
8.4 out of 10, Very good, (1,005 reviews)
"Great staff and well located especially for the West Bank of the city. Slightly too far out for the city etc"
United Kingdom
Glenn
The price is Rp1.526.928
Rp1.969.926 total
includes taxes & fees
30 Aug - 31 Aug
UNA Hotels Vittoria Firenze

5. La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (183 reviews)
"Really nice, handy location"
United Kingdom
Kate
The price is Rp1.868.843
Rp2.305.645 total
includes taxes & fees
24 Aug - 25 Aug
La Fonderia Firenze

6. AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (238 reviews)
"A delight - the perfect escape from the hustle and bustle of Florence A great room full of character The terrace was perfect for breakfast and an early evening drink The staff were very helpful with great restaurant recommendations"
United Kingdom
Peter
The price is Rp5.937.980
Rp6.822.166 total
includes taxes & fees
24 Aug - 25 Aug
AdAstra Suites

7. Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments
Santo Spirito
9.8 out of 10, Exceptional, (152 reviews)
"We had a very nice stay. Claudia was very friendly and service minded The place serves continental breakfast - and is a good idea to supplement it a little bit! Nice and quiet area, where you can walk to most things We can only recommend it Else Marie Hansen May 2026"
Denmark
Else Marie
The price is Rp2.131.102
Rp2.593.045 total
includes taxes & fees
22 Aug - 23 Aug
Drom Florence Rooms & Apartments

8. Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (136 reviews)
"Amazing location, charming hotel and great breakfast"
Sweden
Carin
The price is Rp4.495.956
Rp5.235.856 total
includes taxes & fees
23 Aug - 24 Aug
Oltrarno Splendid

9. Mamo Florence - Aleardi Roof Apartment

Mamo Florence - Aleardi Roof Apartment
Santo Spirito
10.0 out of 10, Exceptional, (1 review)
"Excelente lugar y relacion precio - estancia"
Mexico
Roberto Carlos
The price is Rp1.952.960
Rp4.793.224 total
includes taxes & fees
31 Aug - 1 Sept
Mamo Florence - Aleardi Roof Apartment

10. Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is Rp10.119.201
Rp11.421.426 total
includes taxes & fees
23 Aug - 24 Aug
Torre di Bellosguardo

11. Casa Santo Nome di Gesù

Casa Santo Nome di Gesù
Santo Spirito
8.8 out of 10, Excellent, (379 reviews)
"Excellent location and wonderful staff in a unique building with an amazing history."
United Kingdom
Matthew
The price is Rp2.229.813
Rp2.702.713 total
includes taxes & fees
22 Aug - 23 Aug
Casa Santo Nome di Gesù

12. Home in Florence

Home in Florence
Santo Spirito
9.0 out of 10, Wonderful, (77 reviews)
"Wonderful stay again here-our second time. Beautifully clean, perfect location and friendly staff-thankyou for another lovely stay!"
United Kingdom
Victoria
The price is Rp1.696.587
Rp2.115.079 total
includes taxes & fees
29 Aug - 30 Aug
Home in Florence

13. La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (294 reviews)
"Lovely residence-style building in a quieter neighborhood that is close to all you need."
Canada
Jayme
The price is Rp1.782.715
Rp2.251.291 total
includes taxes & fees
31 Aug - 1 Sept
La Torre Del Cestello

14. Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (176 reviews)
"Quaint boutique hotel in great location. Clean comfortable room and nice breakfast. Wonderful restaurant almost next door and close to train station. Highly recommend."
United States
Timothy
The price is Rp4.043.533
Rp4.738.192 total
includes taxes & fees
6 Sept - 7 Sept
Ottantotto Firenze

15. Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
9.0 out of 10, Wonderful, (167 reviews)
"Excellent place"
United States
Laura Patricia
The price is Rp2.069.043
Rp2.566.252 total
includes taxes & fees
26 Aug - 27 Aug
Residenza D'Epoca Al Numero 8

16. L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B
Santo Spirito
8.6 out of 10, Excellent, (28 reviews)
"Very goord place to stay"
United States
Victor
The price is Rp1.794.299
Rp2.223.647 total
includes taxes & fees
24 Aug - 25 Aug
L'Antica Porta Boutique B&B

17. SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (26 reviews)
"Easy check in and very helpful and polite "
United States
Remi
The price is Rp11.604.658
Rp13.013.956 total
includes taxes & fees
20 Sept - 21 Sept
SPIRIT OF FLORENCE Boutique Rooms

18. Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.4 out of 10, Exceptional, (55 reviews)
"Excellent place to stay!"
United States
Diane
The price is Rp6.635.183
Rp7.547.534 total
includes taxes & fees
19 Sept - 20 Sept
Palazzo D'Oltrarno - Residenza D'Epoca

19. Mamo Florence - Bice & Krizia Apartments

Mamo Florence - Bice & Krizia Apartments
Santo Spirito
8.0 out of 10, Very good, (5 reviews)
"Very nice apartment and great location. The included parking and laundry facilities were the reason we selected the property, and were very happy with everything. Overall a lovely stay. "
United States
Michele
The price is Rp1.944.478
Rp4.876.087 total
includes taxes & fees
31 Aug - 1 Sept
Mamo Florence - Bice & Krizia Apartments

20. Santo Spirito Venti

Santo Spirito Venti
Santo Spirito
8.8 out of 10, Excellent, (86 reviews)
"Thankful the elevator was working. AC on the other hand was not strong enough to beat the heat wave, therefore we did not sleep comfortably for 2 nights. Host was responsive and communicative."
United States
lilian
The price is Rp2.629.710
Rp3.141.514 total
includes taxes & fees
25 Aug - 26 Aug
Santo Spirito Venti
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Find out more about Santo Spirito

Top reasons to visit Santo Spirito

  • Charming Piazza Santo Spirito: Experience the vibrant atmosphere and friendly locals in this picturesque square.
  • Historic San Spirito Church: Visit this remarkable church to appreciate its stunning architecture and rich history.
  • Bustling Public Market: Explore local treasures and savour the flavours of Tuscany at the lively market.
  • Delightful Wine Tours: Indulge in exquisite wine tastings that showcase the best of Tuscan vineyards.
  • Diverse Accommodation Options: Choose from stylish hotels and cosy bed & breakfasts for a personalised stay.

Find great hotels near Santo Spirito

Discover the charm of Santo Spirito with a range of delightful accommodation options, including stylish hotels and cosy bed & breakfasts. Whether you're seeking a city-themed experience or a pet-friendly retreat, you'll find personalised services and unique touches, such as antique furniture and the inviting atmosphere of Palazzo Ridolfi. Enjoy your stay in Florence, where every corner offers a glimpse of history and artistry.

  • The Social Hub Florence Lavagnini: A vibrant 4-star hotel that caters to adventurous spirits and business travellers alike. With a commendable guest rating of 9.0 out of 10, this accommodation is located 2km from Santo Spirito. The Social Hub Florence Lavagnini offers a unique blend of contemporary design and engaging social spaces, making it an ideal choice for those seeking a lively atmosphere. Guests can indulge in various adventure sports and recreational activities either onsite or nearby, ensuring an exciting stay in Florence.
  • B&B Hotel Firenze Pitti Palace al Ponte Vecchio: This charming 4-star property, with a guest rating of 9.0 out of 10, is situated 1km from Santo Spirito. The B&B Hotel Firenze Pitti Palace al Ponte Vecchio is well-suited for families looking for adventure and memorable experiences. With amenities like bicycle rentals available in the vicinity, guests can easily explore the stunning surroundings. The hotel also provides thoughtful services for children, including babysitting and childcare options, making it a family-friendly choice for your stay in Florence.
  • Grand Hotel Cavour: Rated at an impressive 9.2 out of 10, this 4-star hotel is located 2km from Santo Spirito, nestled in a bustling shopping district. The Grand Hotel Cavour is perfect for families and shopping enthusiasts, with a range of amenities tailored for children, including in-room and onsite babysitting services. The hotel’s elegant design and proximity to shopping make it a desirable base for those looking to enjoy both cultural attractions and retail therapy while in Florence.

Where to stay near Santo Spirito

Santo Spirito, nestled in the heart of Florence, offers a vibrant blend of culture and history. Wander through the charming Piazza Santo Spirito, where friendly locals and a romantic atmosphere await. Explore the rich Florentine Renaissance heritage while enjoying trendy cafes and secluded spots. This neighbourhood is perfect for those seeking a luxury experience or a relaxing getaway, making it an ideal base to discover the enchanting essence of Florence and its surroundings.

  • Florence: As the cradle of the Renaissance, Florence boasts an extraordinary blend of art, culture, and history. Located in the heart of Tuscany, this vibrant city attracts visitors year-round, with peak seasons in March to April and September. Here, you can immerse yourself in world-renowned museums, stunning architecture, and charming piazzas. Explore the Uffizi Gallery, marvel at the Florence Cathedral, and stroll across the iconic Ponte Vecchio. The lively atmosphere is complemented by a variety of shopping areas, spas, and theatres, making it an ideal destination for families and culture enthusiasts alike.
  • Duomo: Just 1km from Santo Spirito, the Duomo neighbourhood is famous for its magnificent cathedral, Santa Maria del Fiore, with its striking dome designed by Brunelleschi. This area experiences moderate seasonal fluctuations in visitor numbers, peaking during the summer months. Duomo offers a delightful mix of bustling markets, public squares, and shopping areas, perfect for those looking to immerse themselves in local life. Be sure to wander through the nearby historic sites and enjoy the vibrant street performances that often take place in the piazzas.
  • San Giovanni: Also located 1km from Santo Spirito, San Giovanni is a charming neighbourhood known for its rich history and cultural offerings. Visitors flock here during the summer, making it a lively spot for family-friendly activities and cultural experiences. The area features a blend of shopping areas and public markets, where you can find local delicacies and artisan products. Don’t miss the chance to visit the historic landmarks and picturesque squares that define this enchanting part of Florence.

Things to do near Santo Spirito

Shopping

Santo Spirito offers a charming shopping experience with local boutiques and artisan shops. Explore the vibrant Mercato di Santo Spirito for unique souvenirs, or visit nearby artisan workshops for handmade crafts. Enjoy a leisurely stroll through the area to discover hidden gems and delightful gifts.

Recreation

In Santo Spirito, unwind at the luxurious Villa Cora, where rejuvenating spa treatments and serene gardens create a tranquil escape. Explore the nearby Giardino di Boboli, offering peaceful walks and stunning views, perfect for relaxation amidst nature's beauty.

Adventure

Experience the thrill of motor racing at Mugello Circuit, located 27km from Santo Spirito. Feel the adrenaline rush as you witness high-speed races and enjoy the vibrant atmosphere, perfect for motorsport enthusiasts and adventure seekers alike.

Nightlife

Santo Spirito buzzes with life after dark. Enjoy a glass of wine at Le Volpi e L’Uva, or dive into the vibrant atmosphere at the lively Caffè degli Artigiani. For a laid-back vibe, try the rustic charm of Il Santo Bevitore, where you can unwind with friends.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santo Spirito

Santo Spirito offers budget-friendly travel options for visitors. The best months to save on accommodation are January, February, and November, while Mondays typically offer the lowest rates. For optimal deals, book your hotel at least a month in advance or explore last-minute offers on Expedia. Consider using public transport, which is economical and convenient. Additionally, many attractions in the area can be enjoyed for free, such as exploring the charming streets and local markets. Combining your hotel, flights, and activities into a package can yield significant savings.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santo Spirito are January to February and November, where the prices are slightly lower. This is in comparison to May to June and September, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel around Santo Spirito is usually 1 month out from when you are planning to stay. If you're a little more spontaneous, you could also peruse Expedia's last minute deals which could secure you a cheaper stay. Look out for the green banner below the price to spot the deals.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santo Spirito is Monday. The most expensive day to stay around Santo Spirito is Friday.
  • Find cheap hotels on Expedia: Utilise Expedia's search tool to refine your preferences, including your budget, preferred location, and desired type of accommodation. For instance, selecting the Eco-certified option will reveal sustainable and environmentally-friendly hotels currently available. To find the most affordable prices and offers, arrange the price filter from low to high.
  • Consider bundling your trip: You can make significant savings by combining your hotel reservation in Santo Spirito with your flights and activities through an Expedia package.

Find the best attractions near Santo Spirito

Santo Spirito offers a delightful blend of culture, city exploration, and outdoor activities. Visitors can enjoy the charming Santo Spirito Square, visit the historic San Spirito church, and wander through nearby piazzas and palaces, making it ideal for families and culture enthusiasts alike. Whether you're keen on immersing yourself in local history or simply enjoying the vibrant atmosphere, Santo Spirito is a wonderful destination for a memorable vacation.

  • San Lorenzo Church: Located a mile from Santo Spirito, this church offers a rich cultural atmosphere with its stunning Renaissance architecture and historical significance. Visitors can admire the intricate artworks and the unique layout of the church, which reflects the artistic heritage of Florence.
  • Marsilis Tower: Just 1km away, this historic tower stands as a testament to Florence's medieval past. Its impressive structure and surrounding views provide a glimpse into the city's rich history, making it an intriguing spot for history enthusiasts.
  • Piazza di Santa Maria Novella: Situated 1km from Santo Spirito, this vibrant square is a hub of urban life and culture. Surrounded by beautiful architecture and lively cafés, it's an ideal place to soak in the Florentine atmosphere while enjoying the local scene.

Best time to go to Santo Spirito

The best time to visit Santo Spirito can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santo Spirito falls in July and August. August has moderately high visitor numbers and sunny weather. The coolest average temperature around Santo Spirito falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January41.4°F (5.2°C)Light RainMostly SunnyModerately LowSlightly Low
February43.0°F (6.1°C)Light RainMostly SunnyModerately LowSlightly Low
March47.8°F (8.8°C)Light RainMostly SunnyAverageAverage
April54.3°F (12.4°C)Light RainMostly SunnyAverageAverage
May60.4°F (15.8°C)Light RainMostly SunnyAverageSlightly High
June69.6°F (20.9°C)Light RainSunnyAverageSlightly High
July75.2°F (24.0°C)No RainSunnyModerately HighAverage
August75.2°F (24.0°C)No RainSunnyModerately HighAverage
September67.3°F (19.6°C)Light RainMostly SunnyModerately HighSlightly High
October58.8°F (14.9°C)Light RainMostly SunnyAverageAverage
November50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly Low
December43.5°F (6.4°C)Light RainMostly SunnyModerately LowAverage

The nearest major airports for your trip to Santo Spirito

Reaching Santo Spirito in Florence, Tuscany, is convenient via Florence Airport (FLR-Peretola), located 5km away. Notable hotels nearby include the 5-star Hotel Lungarno, just 5km from the airport, offering transfers and shuttles. The Bernini Palace, situated 6km away, also provides various transportation services, including an airport shuttle. For those considering Bologna Airport (BLQ-Guglielmo Marconi), located 85km away, the Grand Hotel Majestic and Starhotels Excelsior are excellent 5-star options, both 5km from the airport and offering shuttle services. Pisa Airport (PSA-Galileo Galilei) is 68km from Santo Spirito, with the 5-star Hotel Pisa Tower Plaza just 3km from the airport.

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Piazza Santo Spirito and Santo Spirito Basilica as part of your Santo Spirito travel plans.
What's a favourite place to stay in Santo Spirito?
Based on our traveller data, Hotel Horto Convento is one of the top choices for your stay in Santo Spirito. This hotel is a short 14-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and a bar. Other good options for your stay in the neighbourhood include La Torre Del Cestello and UNA Hotels Vittoria Firenze.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 524 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.
What can I see and do in this Florence neighbourhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Piazza Santo Spirito and Santo Spirito Basilica are some other places worth a visit. Piazza di Santa Maria Novella and Piazza del Duomo are some popular places to visit in the area around Santo Spirito. When you're sightseeing in Florence, Piazza del Carmine and Santa Maria della Carmine are also worth a stop.