Santo Spirito Travel Guide
Florence
Visit Santo Spirito
Popular places to visit
Piazza Santo Spirito
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the fascinating museums and notable monuments in this vibrant area.
Porta Romana
Find out about the history of Arcetri when you spend time at Porta Romana. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.
Brancacci Chapel
A dazzling array of Renaissance frescoes adorn the walls of the most famous chapel of Florence’s 750-year-old Church of Santa Maria del Carmine.
Santo Spirito Basilica
Learn about the local history of Florence when you take a trip to Santo Spirito Basilica. Stroll along the riverfront or visit the churches in this vibrant area.
Torrigiani Garden
Explore the great outdoors at Torrigiani Garden, a lovely green space in Florence. Stroll along the riverfront or visit the stunning cathedral in this vibrant area.
Piazza del Carmine
You can learn about the history of Florence with a trip to Piazza del Carmine. Amble around this vibrant area's riverfront or experience its acclaimed art galleries.
Things to do
Florence Accademia Gallery Tour with Entrance Ticket Included
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti
The Best of Tuscany in One Day Sightseeing Tour
Skip the Line: Florence's Accademia Gallery Priority Entrance Ticket
Siena, San Gimignano, Monteriggioni & Chianti from Florence
Pisa, Siena and San Gimignano day trip from Florence
Top hotels in Santo Spirito
Hotel Horto Convento
Our stay was fantastic! The breakfast was delicious, the drinks were amazing and the staff was a delight. I absolutely love the fact that we were able to sleep in peace with no outside noise. If I go back to Florence, I would definitely stay at this hotel again
Reviewed on 6 Feb 2026
Palazzo Mannaioni Suites
Very helpful at the front desk. Check in was seamless - very attentive staff to all of our needs :)
Reviewed on 5 Feb 2026
UNA Hotels Vittoria Firenze
Perfect stay! Not only was the check-in smooth, but everything else was also satisfying. The breakfast was delicious, the staff were friendly, and the location was ideal. There wasn't a single thing I didn't like. I’ll definitely be back!
Reviewed on 1 Jan 2026
La Torre Del Cestello
The Torre del Cestello had the "Room with a View" (complete with garden below) that I had been dreaming of for my first visit to Florence. The desk staff were all pleasant, helpful, and set me up with a map and suggestions when I checked in. There was easy access in and out of the room. Quiet but ...
Reviewed on 18 Jan 2026
Casa Santo Nome di Gesù
Pretty neat place. Run by nuns. Great building. Friendly staff Breakfast included. Rooms simple clean. Beautiful location. Would definitely go back.
Reviewed on 28 Jan 2026
Oltrarno Splendid
Fantastic hotel in a really vibrant neighborhood full of amazing food, shops and historical sites. Great staff. Breakfast was varied enough to keep our interest for 6 days. Can’t recommend this hotel any more highly.
Reviewed on 28 Jan 2026
Other neighbourhoods around Santo Spirito
San Frediano
San Frediano is known for its stunning river views, and you can plan a trip to Piazza Santo Spirito and Boboli Gardens while you're in town.
Oltrarno
Oltrarno is a destination visitors seek out for its fascinating museums, picturesque gardens and beautiful river views. You might also want to check out attractions like Pitti Palace or Via Maggio while you're exploring the neighbourhood.
Santa Maria Novella
Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.
San Giovanni
If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.
Historic Centre of Florence
Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza di Santa Maria Novella and Via de' Calzaiuoli are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.
Duomo
Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.
