Search Hotels in Santo Spirito, Florence

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santo Spirito hotels

Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (603)
"Excellent stay"
United States
Renata
The price is Rp2.001.981
Rp2.478.142 total
includes taxes & fees
25 Jan - 26 Jan 2026
Hotel Horto Convento

Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments
Santo Spirito
9.8 out of 10, Exceptional, (136)
"Ver clean and quiet, wonderful stay."
United States
kevin
Drom Florence Rooms & Apartments

Mamo Florence - Bice & Krizia Apartments

Mamo Florence - Bice & Krizia Apartments
Santo Spirito
9.0 out of 10, Wonderful, (2)
"Nice stay. Location was slightly off the beaten track, which we liked. Staff were responsive to us on the phone immediately. Nice flat."
United States
Christopher Pat
The price is Rp1.475.823
Rp3.635.403 total
includes taxes & fees
12 Jan - 13 Jan 2026
Mamo Florence - Bice & Krizia Apartments

Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (97)
"It was Wonderful!!!"
United States
MARGARITA
The price is Rp2.592.733
Rp3.128.162 total
includes taxes & fees
19 Jan - 20 Jan 2026
Oltrarno Splendid

La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (172)
"Breakfast outside was lovely"
United States
Kenneth
The price is Rp1.648.951
Rp2.050.385 total
includes taxes & fees
18 Jan - 19 Jan 2026
La Fonderia Firenze

La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (230)
"Great location and great rooms"
United States
David
The price is Rp1.681.076
Rp2.125.146 total
includes taxes & fees
11 Jan - 12 Jan 2026
La Torre Del Cestello

Santo Spirito Venti

Santo Spirito Venti
Santo Spirito
8.8 out of 10, Excellent, (59)
"Great location, friendly staff, I definitely recommend it."
Canada
Pedro
Santo Spirito Venti

Home in Florence

Home in Florence
Santo Spirito
9.0 out of 10, Wonderful, (70)
"Perfect place, super friendly owners, really helpful. "
United Kingdom
Paul
The price is Rp1.507.937
Rp1.895.270 total
includes taxes & fees
26 Jan - 27 Jan 2026
Home in Florence

Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1073)
"Perfect stay"
United States
Juan P
Palazzo Mannaioni Suites

UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze
4.0 star property
Santo Spirito
8.4 out of 10, Very good, (1000)
"Super nice reception staffs, everyone is so friendly and welcoming. But don’t like the red room decoration. "
Canada
Tina
The price is Rp2.257.874
Rp2.759.623 total
includes taxes & fees
9 Jan - 10 Jan 2026
UNA Hotels Vittoria Firenze

AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (221)
"Great Room - Lovely breakfast excellent strong Cappuccino and lovely yoghurts. Thanks see you soon. "
United Kingdom
Tim
The price is Rp3.048.129
Rp3.628.904 total
includes taxes & fees
18 Jan - 19 Jan 2026
AdAstra Suites

SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (24)
"This boutique was an absolute must stay. From the location to the comfort of our room and the lovely staff, it was all you could ask for during a stay in Florence. The walkability was incredible, and even though there is a lively crowd nightly outside of the building, your room is peaceful. Highly recommend this hotel to anyone looking for a unique stay in Florence! "
United States
Chris
The price is Rp2.677.193
Rp3.181.451 total
includes taxes & fees
20 Jan - 21 Jan 2026
SPIRIT OF FLORENCE Boutique Rooms

Mamo Florence - Margot Apartment

Mamo Florence - Margot Apartment
Santo Spirito
10.0 out of 10, Exceptional, (1)
"Good"
Italy
Lynette
The price is Rp2.184.326
Rp4.651.461 total
includes taxes & fees
9 Jan - 10 Jan 2026
Mamo Florence - Margot Apartment

Appartamenti degli Artisti by Mmega

Appartamenti degli Artisti by Mmega
Santo Spirito
8.6 out of 10, Excellent, (29)
"We stayed here in November and had a wonderful experience. The location worked perfectly for my husband and I, close enough to the center to get everywhere easily, yet set in a quiet residential part of Florence where we could feel the local rhythm of the city. The staff who look after the house were all very easy to communicate with. The whole stay was smooth and comfortable. We truly enjoyed our time here!"
United States
Ray
The price is Rp1.427.944
Rp3.384.205 total
includes taxes & fees
26 Jan - 27 Jan 2026
Appartamenti degli Artisti by Mmega

Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.4 out of 10, Exceptional, (46)
"Excellent place to stay!"
United States
Diane
The price is Rp1.984.292
Rp2.419.427 total
includes taxes & fees
18 Jan - 19 Jan 2026
Palazzo D'Oltrarno - Residenza D'Epoca

1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (177)
"This property is great and the manager is very kind and helpful."
United States
Elizabeth
1900 Artevita

Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
8.8 out of 10, Excellent, (139)
"Our stay was wonderful! Roxy was so welcoming and helpful! The room and view was beautiful as well! Great location with amazing food and sights nearby! "
United States
Jacqueline
The price is Rp1.681.076
Rp2.125.146 total
includes taxes & fees
27 Jan - 28 Jan 2026
Residenza D'Epoca Al Numero 8

Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103)
"Beautiful property and wonderful staff."
United States
Brad
The price is Rp6.340.037
Rp7.249.925 total
includes taxes & fees
3 Jan - 4 Jan 2026
Torre di Bellosguardo

Hotel Firenze 2000

Hotel Firenze 2000
2.0 star property
Santo Spirito
7.2 out of 10, Good, (189)
"The staff was wonderful and very helpful; 24 hr service ! The room was very clean and breakfast was plentiful. Great location if you don’t mind a short walk to the historic town center ; would definitely recommend."
Canada
Josee
The price is Rp1.115.385
Rp1.404.453 total
includes taxes & fees
19 Jan - 20 Jan 2026
Hotel Firenze 2000

Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (193)
"The room was clean a d comfortable, and the staff was very courteous and helpful. The location was also good with most attractions being a 30 to 40 minute walk or less."
United States
Roger
Foresteria Valdese di Firenze - Casa per Ferie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza di Santa Maria Novella or Via de' Calzaiuoli while you're exploring the neighbourhood.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Find out more about Santo Spirito

Top reasons to visit Santo Spirito

  • Vibrant Market Experience: Explore the lively public market and shopping areas, offering a taste of local life and unique products.
  • Culinary Delights: Indulge in exquisite Tuscan cuisine at charming eateries, showcasing authentic flavours of the region.
  • Cultural Richness: Discover historic churches, captivating art museums, and charming piazzas that reflect Florence's artistic heritage.
  • Picturesque Strolls: Wander through quaint streets, enjoying breathtaking views and the warm atmosphere of friendly locals.
  • Authentic Accommodations: Choose from a variety of charming hotels and bed & breakfasts that enhance your Florentine experience.

Find great hotels near Santo Spirito

In the charming neighbourhood of Santo Spirito, Florence, you'll discover a delightful selection of accommodations, including hotels and bed & breakfasts tailored to your needs. Whether you seek a pet-friendly stay, city-themed amenities, or easy access to shopping, this area offers a variety of options. Enjoy the unique atmosphere of Santo Spirito while selecting from accessible hotels and cosy lodgings that cater to all your travel desires in beautiful Tuscany.

  • c-hotels Ambasciatori: This 4-star hotel offers a blend of comfort and convenience, perfect for both business and leisure travellers. Located 1.3km from Santo Spirito, c-hotels Ambasciatori is pet-friendly, ensuring that your furry companions are welcome too. The hotel boasts essential amenities like food and water bowls for pets, creating a homely atmosphere. Guests can enjoy a range of business facilities alongside personalised service, making it an ideal choice for professionals on the move.
  • Globus Urban Hotel: Situated 1.6km from Santo Spirito, the Globus Urban Hotel is a vibrant 4-star establishment tailored for the adventurous spirit. Nestled in the heart of the shopping district, it offers easy access to a variety of city attractions. Guests can partake in exciting activities such as hiking, biking, and exploring on scooters, immersing themselves in Florence’s dynamic landscape. The hotel’s chic urban theme enhances the overall experience, making it a perfect choice for those seeking excitement and convenience.
  • Hotel Pendini: Located 1.4km from Santo Spirito, this charming 3-star hotel combines city-themed elegance with pet-friendly policies. Hotel Pendini is set in a bustling shopping district, making it an excellent choice for shoppers and explorers alike. The property allows dogs and has specific pet policies to ensure a comfortable stay for all guests. The warm atmosphere and central location make it a popular pick for those looking to delve into Florence's vibrant culture while enjoying the comforts of home.

Where to stay near Santo Spirito

Discover the authentic charm of Santo Spirito, nestled in the heart of historic Florence. This trendy neighbourhood offers a delightful mix of culture and relaxation, where you can admire breathtaking views and experience the warmth of friendly locals. Stroll through its quaint streets, visit artisan shops, and savour exquisite Tuscan cuisine. Nearby, explore the romantic ambience of the Oltrarno district, making it an ideal base for an unforgettable Florentine getaway.

  • Florence: As the heart of Tuscany, Florence is a city steeped in art and history, making it an essential stop for any traveller. Its bustling streets are alive with culture-themed experiences, from the iconic Uffizi Gallery to the historic Ponte Vecchio. Visitors can enjoy vibrant local markets and exquisite shopping areas, all while soaking in the beauty of its piazza squares and historic landmarks. The city’s charm peaks from March to April and September, providing a rich tapestry of experiences for families and culture enthusiasts alike.
  • Duomo: Located a mere 1.4km from Santo Spirito, Duomo is renowned for its stunning cathedral, the Santa Maria del Fiore, which dominates the skyline. This neighbourhood offers a moderately seasonal travel experience, with peak visitor numbers from July to September. Duomo is a hub for culture-themed activities, featuring bustling markets and educational venues. Visitors can stroll through its picturesque piazza squares and explore the nearby bridges, making it a delightful area for families and culture seekers to immerse themselves in Florentine life.
  • Santa Maria Novella: Just 1.4km from Santo Spirito, Santa Maria Novella is a vibrant neighbourhood that blends history with modern-day living. The area is consistently popular among travellers, especially during the spring and autumn months. With its charming public markets and shopping areas, it's perfect for those seeking a taste of local life. Notable landmarks include the splendid basilica and historic places, making it a rich cultural experience for families and tourists alike. Santa Maria Novella’s atmosphere is both welcoming and engaging, ensuring a memorable visit.

Things to do near Santo Spirito

Santo Spirito offers a delightful blend of cultural and outdoor activities for visitors. You can explore the vibrant public market and shopping areas, indulge in local cuisine, and enjoy various sports activities. Additionally, consider taking an apartment tour to immerse yourself in the authentic Florentine lifestyle. This charming neighbourhood is perfect for those seeking a rich cultural experience while enjoying the picturesque streets of Florence.

Shopping

Santo Spirito offers a delightful shopping experience. Visit the Central Market, a vibrant public market just 1.6km away, or explore Pitti Vintage, a charming store located 966m from the area. Don't miss the Mercato di Sant'Ambrogio, another lively market 3.2km away, perfect for unique souvenirs.

Recreation

At Hidron, indulge in family-friendly aquatic activities, perfect for relaxation and fun, located a mere 11.3km from Santo Spirito. For sports enthusiasts, the Stadio Artemio Franchi offers a vibrant atmosphere just 3.2km away, while the Nelson Mandela Forum provides a serene space for wellness and relaxation, also 3.2km distant.

Adventure

Experience the thrill of FiesoleBike Day Tours, offering outdoor cycling adventures just 1.6km from Santo Spirito, where you can soak in the stunning landscapes. For motorsport enthusiasts, the Mugello Circuit, located 27.4km away, promises exhilarating races. Enjoy scenic hikes at Parco di Montececeri, only 6.4km away, amidst breathtaking views.

Nightlife

In Santo Spirito, enjoy a vibrant nightlife with venues like Teatro Verdi and Teatro della Pergola, both offering a romantic atmosphere filled with culture and entertainment. For a family-friendly outing, visit the nearby Arcetri Observatory, where you can marvel at the stars while soaking in the fun vibes.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santo Spirito

Santo Spirito offers budget-friendly travel options for visitors. The best months to save on accommodation are January, February, and November, while Mondays typically offer the lowest rates. For optimal deals, book your hotel at least a month in advance or explore last-minute offers on Expedia. Consider using public transport, which is economical and convenient. Additionally, many attractions in the area can be enjoyed for free, such as exploring the charming streets and local markets. Combining your hotel, flights, and activities into a package can yield significant savings.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santo Spirito are January to February and November, where the prices are slightly lower. This is in comparison to May to June and September, where prices are slightly higher.
  • The best time to book a hotel: The cheapest time to book a hotel around Santo Spirito is usually 1 month out from when you are planning to stay. If you're a little more spontaneous, you could also peruse Expedia's last minute deals which could secure you a cheaper stay. Look out for the green banner below the price to spot the deals.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santo Spirito is Monday. The most expensive day to stay around Santo Spirito is Friday.
  • Find cheap hotels on Expedia: Utilise Expedia's search tool to refine your preferences, including your budget, preferred location, and desired type of accommodation. For instance, selecting the Eco-certified option will reveal sustainable and environmentally-friendly hotels currently available. To find the most affordable prices and offers, arrange the price filter from low to high.
  • Consider bundling your trip: You can make significant savings by combining your hotel reservation in Santo Spirito with your flights and activities through an Expedia package.

Find the best attractions near Santo Spirito

Santo Spirito offers a rich cultural experience for tourists seeking a blend of city life and outdoor activities. Notable attractions include the charming piazzas, historic churches, and captivating art museums. This vibrant area caters to families and culture enthusiasts alike, ensuring a memorable visit filled with exploration and discovery.

  • San Lorenzo Church: Located approximately 1.6km from Santo Spirito, San Lorenzo Church is a remarkable example of Renaissance architecture, renowned for its cultural significance and serene atmosphere that invites contemplation.
  • Accademia delle Arti del Disegno: Just 1.4km away, this historic academy showcases stunning art and architecture, providing a glimpse into Florence's artistic heritage amidst picturesque urban scenery.
  • Florence Design Academy: Situated 1.6km from Santo Spirito, this modern institution is a hub of creativity and innovation, offering a vibrant city vibe that inspires aspiring designers and artists alike.

Best time to go to Santo Spirito

The best time to visit Santo Spirito can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Santo Spirito falls in July and August. August has moderately high visitor numbers and sunny weather. The coolest average temperature around Santo Spirito falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January41.4°F (5.2°C)Light RainMostly SunnyModerately LowSlightly Low
February43.0°F (6.1°C)Light RainMostly SunnyModerately LowSlightly Low
March47.8°F (8.8°C)Light RainMostly SunnyAverageAverage
April54.3°F (12.4°C)Light RainMostly SunnyAverageAverage
May60.4°F (15.8°C)Light RainMostly SunnyAverageSlightly High
June69.6°F (20.9°C)Light RainSunnyAverageSlightly High
July75.2°F (24.0°C)No RainSunnyModerately HighAverage
August75.2°F (24.0°C)No RainSunnyModerately HighAverage
September67.3°F (19.6°C)Light RainMostly SunnyModerately HighSlightly High
October58.8°F (14.9°C)Light RainMostly SunnyAverageAverage
November50.2°F (10.1°C)Light RainMostly SunnyAverageSlightly Low
December43.5°F (6.4°C)Light RainMostly SunnyModerately LowAverage

The nearest major airports for your trip to Santo Spirito

When travelling to Santo Spirito in Florence, the major airport options include Florence Airport (FLR-Peretola), located 4.8km away, Bologna Airport (BLQ-Guglielmo Marconi) at 54.8km, and Pisa Airport (PSA-Galileo Galilei) which is 67.6km distant. Near Florence Airport, excellent hotel choices are the 5-star Sina Villa Medici, featuring 24-hour airport shuttle services, and the Four Seasons Hotel Firenze, both 3-6.4km away. For Bologna Airport, the 4.5-star Hotel Maxim and Hotel Internazionale offer convenient access. In Pisa, the 5-star Hotel Villa Casanova and Grand Hotel Bonanno provide shuttle services, ensuring a smooth transition from the airports to your accommodation.

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighbourhood known for its stunning river views. Make sure that you visit Porta Romana and Piazza Santo Spirito as part of your Santo Spirito travel plans.
What's a favourite place to stay in Santo Spirito?
Based on Expedia customer reviews, Oltrarno Splendid is the highest ranked property in Santo Spirito. This B&B is a short 7-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and free WiFi. Other favourite options in the area include AdAstra Suites and SPIRIT OF FLORENCE Boutique Rooms.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 480 hotels and other accommodation options in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of booking. Enter dates in and click on "Search", then filter by "fully refundable" to get top deals in Santo Spirito.
What can I see and do in this Florence neighbourhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighbourhood, Porta Romana and Piazza Santo Spirito are some other places worth a visit. A few places to visit in the area around Santo Spirito include Piazza di Santa Maria Novella, Piazza del Carmine and Santa Maria della Carmine. When you're sightseeing in Florence, Brancacci Chapel and Il Nabucco di Matteo Gabellini are also worth a stop.