South Main Travel Guide
Houston
Visit South Main
Popular places to visit
NRG Stadium
Catch an event at NRG Stadium during your trip to Houston. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
George R. Brown Convention Center
During your trip, find out what's happening in George R. Brown Convention Center, a top convention centre in Houston. Experience the great live music and lively festivals in this vibrant area.
NASA Johnson Space Center
After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event.
Daikin Park
Catch an event at Daikin Park during your trip to Houston. Experience the lively festivals and great live music in this vibrant area.
Toyota Center
Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed art galleries and entertainment choices in this vibrant area.
Space Center Houston
This iconic “mission control” was immortalized for its role in the first moon landing.
Things to do
Space Center Houston Admission Ticket
Houston's Official City & Mural Tour!
Houston: Houston Botanic Garden Entry Ticket
Astroville Tunnel Tour of Downtown Houston (Air-Conditioned)
Houston: Children's Museum Houston Entry Ticket
Top hotels in South Main
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
The room was quite spacious.
Reviewed on 30 Jan 2026
Blossom Hotel Houston, Curio Collection by Hilton
Service was excellent
Reviewed on 1 Feb 2026
Hotel Zaza Houston Museum District
All aspects of Hotel Zaza are consistently excellent. Rooms are clean & comfortable. Staff is friendly & accommodating regardless of how busy they are. Excellent restaurant. Highly recommended
Reviewed on 27 Jan 2026
The Whitehall Houston
Staff was very welcoming and nice! My experience was lovely and I enjoyed a great view of outside! Everything I needed I had there, very organized.
Reviewed on 1 Feb 2026
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
Estancia cómoda, limpieza muy bien, desayuno limitado y el mismo,
Reviewed on 31 Jan 2026
Club Quarters Hotel Downtown, Houston
Great staff! Only issue was the slow elevator
Reviewed on 2 Feb 2026
Other neighbourhoods around South Main
Astrodome
While you're in Astrodome, take in top sights like NRG Stadium or NRG Arena, and hop on the metro to see more of the city at Stadium Park/Astrodome Station or Smith Lands Station.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Museum District
Known for its abundant dining options and interesting museums, there's plenty to explore in Museum District. Top attractions like Children's Museum of Houston and Houston Natural Science Museum are major draws, and you can catch the metro at Museum District Station or Hermann Park/Rice U Station to see more of the city.
South Central Houston
If you're spending time in South Central Houston, check out sights like Children's Museum of Houston or Houston Natural Science Museum and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Greater Third Ward
If you're spending time in Greater Third Ward, check out sights like Carl Lewis International Track and Field Complex or Fertitta Center and hop on the metro to see more of the city at Elgin/Third Ward Station or TSU/UH Athletics District Station.
