The Best Hotels in Mayo Clinic, Phoenix - 2026 Updated Prices

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Our top choices for Mayo Clinic hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

Mayo Clinic

Michael

Rp2.198.355 total

includes taxes & fees

21 Oct - 22 Oct

A modern infinity pool with a view of mountains and a sunset.

2. Talking Stick Resort

9 km from Mayo Clinic

Jessica

Rp4.684.185 total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with two beds, a desk with a chair, a TV, and a lamp.

3. Comfort Suites Scottsdale Talking Stick Entertainment District

9.7 km from Mayo Clinic

LAURA

Rp2.238.372 total

includes taxes & fees

1 Nov - 2 Nov

A hotel lobby with a reception desk, seating area, and a large wall mural.

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

Central Scottsdale, 9 km from Mayo Clinic

Wilson

Rp1.728.892 total

includes taxes & fees

25 Oct - 26 Oct

A water park with a multi-level water slide, palm trees, and a pool area with lounge chairs.

5. Holiday Inn Club Vacations Scottsdale Resort by IHG

13.3 km from Mayo Clinic

Nadine

Rp4.910.375 total

includes taxes & fees

2 Nov - 3 Nov

A cluster of modern, multi-story buildings with a river in the foreground.

6. Inn at Eagle Mountain

3 km from Mayo Clinic

Stephanie

Rp2.649.349 total

includes taxes & fees

25 Oct - 26 Oct

A Holiday Inn Express & Suites reception desk with a modern design, including a digital display and a sign above the desk.

7. Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

20.2 km from Mayo Clinic

Than

Rp3.115.246 total

includes taxes & fees

1 Nov - 2 Nov

A courtyard with outdoor seating and a fire pit, surrounded by a building with multiple windows and doors.

8. Aiden by Best Western Scottsdale North

8.8 km from Mayo Clinic

Marie

Rp2.101.997 total

includes taxes & fees

26 Oct - 27 Oct

An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

9. Wekopa Casino Resort

10.1 km from Mayo Clinic

jennifer

Rp2.930.215 total

includes taxes & fees

20 Oct - 21 Oct

An outdoor dining area with wicker furniture and candles, overlooking a well-maintained garden and buildings.

10. Sonesta Suites Scottsdale Gainey Ranch

12.4 km from Mayo Clinic

Eric

Rp3.677.964 total

includes taxes & fees

25 Oct - 26 Oct

A building with a symmetrical facade, multiple balconies, and a central entrance.

11. Hilton Vacation Club Scottsdale Links Resort

11.4 km from Mayo Clinic

Jacob

Rp3.213.206 total

includes taxes & fees

28 Oct - 29 Oct

An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

12. Hyatt Place Scottsdale - North

14.2 km from Mayo Clinic

Ted

Rp3.451.622 total

includes taxes & fees

25 Oct - 26 Oct

A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

13. Hyatt House North Scottsdale

14.2 km from Mayo Clinic

Cassie

Rp2.773.625 total

includes taxes & fees

25 Oct - 26 Oct

A woman in a swimsuit and straw hat by a pool with a rock waterfall and lounge chairs in the background.

14. Hilton Phoenix Tapatio Cliffs Resort

25.4 km from Mayo Clinic

Dwight

Rp3.199.651 total

includes taxes & fees

30 Oct - 31 Oct

A spacious lobby with a large seating area, a reception desk, and artwork on the walls.

15. Best Western Plus Scottsdale Thunderbird Suites

Thunderbird Industrial Airpark, 12.3 km from Mayo Clinic

Susan

Rp2.307.657 total

includes taxes & fees

26 Oct - 27 Oct

A spacious living area with a kitchen, modern furniture, and a fireplace.

16. Fountain Park Hotel, BW Signature Collection

7.2 km from Mayo Clinic

Guadalupe

Rp2.243.376 total

includes taxes & fees

21 Oct - 22 Oct

A modern breakfast area with a sign reading "EXPRESS START BREAKFAST" and a "GOOD MORNING" sign on the wall.

17. Holiday Inn Express & Suites Phoenix - Airport North by IHG

23.2 km from Mayo Clinic

XIN

Rp2.445.976 total

includes taxes & fees

1 Nov - 2 Nov

An indoor water park with slides, a wave pool, and seating areas.

18. Great Wolf Lodge Arizona

10.3 km from Mayo Clinic

Dejanira

Rp3.353.081 total

includes taxes & fees

1 Nov - 2 Nov

A modern lobby with a sofa, a coffee table, and a seating area with chairs.

19. Holiday Inn Hotel & Suites PHOENIX AIRPORT by IHG

25.4 km from Mayo Clinic

linda

Rp2.292.867 total

includes taxes & fees

1 Nov - 2 Nov

A spacious lobby with a high ceiling, multiple seating areas, a reception desk, and a television screen.

20. Embassy Suites by Hilton Phoenix Scottsdale

17.9 km from Mayo Clinic

Matthew

Rp3.209.119 total

includes taxes & fees

1 Nov - 2 Nov

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Where to stay in Mayo Clinic

Find the best Mayo Clinic areas for the activities you enjoy most.

A cityscape with prominent buildings including a Chase bank and The Arizona Republic building.

Downtown Phoenix

Cheer on the Phoenix Suns at an NBA game or walk around the city’s historic precinct as you explore the state capital.

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A fountain with three horses, surrounded by red flowers and storefronts.

Old Town

Gourmet restaurants interesting history and top sights from Scottsdale Waterfront to Western Spirit: Scottsdale's Museum of the West – discover Old Town, a destination also famous for its shopping.

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A hiker on a rocky trail with mountains in the background.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Golf Club Scottsdale and Tom's Thumb Trail.

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A rocky hill with palm trees and a body of water.

Camelback East

You might take some time to check out the abundant dining options in Camelback East. Spend some time visiting top spots like Biltmore Fashion Park, and catch the metro at 44th Street - Washington Station or 50th Street Station to see more of the area.

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A mountainous landscape with a city in the valley below.

North Phoenix

While you're in North Phoenix, take in top sights like Reach 11 Sports Complex and jump on the metro at 19th Avenue/ Dunlap Station to see more of the city.

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Top Mayo Clinic Hotel Reviews

DoubleTree Resort by Hilton Paradise Valley - Scottsdale

8/10 Good

"Great location, great shuttle service to downtown. Hotel is currently remodeling and had lots of construction going on, but noise was minimal. Room was newly updated, looked great. Loved the warm cookies upon checkin."

FOUNDRE Phoenix

8/10 Good

"Great location sexy and chic hotel. The rooms give and industrial vibe but very chic. The art that is displayed throughout the hotel was amazing. The meet far that I can go down stairs to catch breakfast brunch lunch and dinner at Match is amazing. The staff at this location was amazing in particular Ms KAZ always greeting me with a smile very pleasant and the right person for the job. Onlyyyyy complaint in the room area the bed railing was dusty and the room had a strong male cologne scent I didn’t really like it. Over all comfort quality location vibe was a 10"

Arizona Biltmore, LXR Hotels & Resorts

10/10 Excellent

"Beautiful, well maintained property that is an architectural gem. Room was recently renovated and clean. Pools are generally great, although the larger one with the water slide (which is a lot of fun), could have been cleaned and there was a lack of staff at that one. Other than that, it’s a really special hotel."

Frequently asked questions

What is Mayo Clinic like?

Travellers will be sure to find plenty to entertain them in Scottsdale's Mayo Clinic neighbourhood.

Where is the best place to stay in Mayo Clinic?

Based on Expedia customer reviews, Sonesta Select Scottsdale at Mayo Clinic Campus is the highest ranked property in Mayo Clinic. This hotel offers a restaurant and an outdoor pool.

How many hotels should I expect to find in the Mayo Clinic area?

With 14 Expedia hotels and other accommodation options in Mayo Clinic to choose from, this is a good starting point for exploring the greater Scottsdale area.

If I need to cancel my hotel reservation in Mayo Clinic, will I receive a refund?

Yes! Most hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then you can filter by "fully refundable" to view the best options available in Mayo Clinic.

What is there to do around this Scottsdale neighbourhood?

A few places to visit in the area around Mayo Clinic include Eagle Mountain Golf Course, Golf Club at Eagle Mountain and SunRidge Canyon Golf Club. Make a stop at Talking Stick Resort Casino and OdySea Aquarium while you're sightseeing around the area.

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Our top choices for Mayo Clinic hotels

1. Sonesta Select Scottsdale at Mayo Clinic Campus

2. Talking Stick Resort

3. Comfort Suites Scottsdale Talking Stick Entertainment District

4. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

5. Holiday Inn Club Vacations Scottsdale Resort by IHG

6. Inn at Eagle Mountain

7. Holiday Inn Express Hotel & Suites Phoenix North Scottsdale by IHG

8. Aiden by Best Western Scottsdale North

9. Wekopa Casino Resort

10. Sonesta Suites Scottsdale Gainey Ranch

11. Hilton Vacation Club Scottsdale Links Resort

12. Hyatt Place Scottsdale - North

13. Hyatt House North Scottsdale

14. Hilton Phoenix Tapatio Cliffs Resort

15. Best Western Plus Scottsdale Thunderbird Suites

16. Fountain Park Hotel, BW Signature Collection

17. Holiday Inn Express & Suites Phoenix - Airport North by IHG

18. Great Wolf Lodge Arizona

19. Holiday Inn Hotel & Suites PHOENIX AIRPORT by IHG

20. Embassy Suites by Hilton Phoenix Scottsdale

Where to stay in Mayo Clinic

Downtown Phoenix

Old Town

Rio Verde Foothills

Camelback East

North Phoenix

Top Mayo Clinic Hotel Reviews

DoubleTree Resort by Hilton Paradise Valley - Scottsdale

Frequently asked questions

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