Otay Mesa Travel Guide
San Diego



Visit Otay Mesa
Stay near popular Otay Mesa attractions
Things to do

From Tijuana: Valle de Guadalupe Private Winery Tour

From Tijuana: Valle de Guadalupe Shared Winery Tour

Taco Tuesday Hop to Tijuana from San Diego

Tijuana: Guided City Tour with Local Food and Beer Tasting

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
"Staff was amazing and beds were sooo comfy"
Reviewed on 19 Oct 2026

Wyndham San Diego Bayside
"Love this place! It’s right in the heart of so much to do in SD."
Reviewed on 18 Oct 2026

Handlery Hotel
"The parking was a little confusing on my first time there. Scanning room card at the proper area of the machine."
Reviewed on 19 Oct 2026

Bay Club Hotel & Marina
"We loved where the hotel was located! Lots of restaurants nearby. The rooms were a nice size. We had a view of the harbor. We would definitely stay here again!"
Reviewed on 19 Oct 2026

Paradise Point Resort & Spa

Sheraton San Diego Resort
Where to stay in Otay Mesa

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach
The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

Gaslamp Quarter
Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Nova SD – discover Gaslamp Quarter, a destination also famous for its shopping.

Mission Beach
If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

















