A white colonial church with ornate architecture and a large wooden door.

Search Hotels in Santa Ana, Antigua Guatemala

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Santa Ana hotels

A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

1. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is Rp678.698
Rp828.012 total
includes taxes & fees
18 Oct - 19 Oct
Hostal Casa Buho
A room with two beds, a small table with a lamp, a window with a curtain, and a wall-mounted mirror.

2. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is Rp236.919
Rp506.775 total
includes taxes & fees
6 Oct - 7 Oct
Castillo De Los Gigantes
A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

3. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
Villas Santa Ana-Ricardo
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

4. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (249 reviews)
"The staff was very friendly and the room and surrounding property were very pretty and clean"
United States
Logan
The price is Rp1.523.911
Rp1.859.171 total
includes taxes & fees
24 Sept - 25 Sept
Casa Noble Hotel
Hotel Villa Colonial with a colonial architectural style, featuring a large arched entrance and a signboard.

5. Villa Colonial

Villa Colonial
3.0 star property
0.7 km from Santa Ana
9.2 out of 10, Wonderful, (216 reviews)
"The whole experience was good"
United States
Mercedes
The price is Rp1.525.918
Rp1.861.620 total
includes taxes & fees
24 Sept - 25 Sept
Villa Colonial
A covered outdoor area with a stone staircase, lush greenery, and a seating area with tables and chairs.

6. Hotel Eterna Primavera Antigua

Hotel Eterna Primavera Antigua
3.0 star property
Historic Center, 1.1 km from Santa Ana
8.8 out of 10, Excellent, (322 reviews)
"Good parking option and breakfast included"
United States
Carlos
The price is Rp1.365.296
Rp1.665.661 total
includes taxes & fees
1 Oct - 2 Oct
Hotel Eterna Primavera Antigua
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

7. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (922 reviews)
"Excelent place"
United States
Gaston
The price is Rp1.325.069
Rp1.616.584 total
includes taxes & fees
27 Sept - 28 Sept
El Carmen Hotel
A restaurant with a brick wall, wine racks, and tables set for dining.

8. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,004 reviews)
"Great breakfast."
Canada
Harvey
The price is Rp2.446.312
Rp3.091.804 total
includes taxes & fees
14 Oct - 15 Oct
Los Pasos Boutique Hotel & Spa

9. Hotel Genessis

Hotel Genessis
3.5 star property
0.9 km from Santa Ana
9.2 out of 10, Wonderful, (145 reviews)
"Excellent hotel! So happy we chose Hotel Genessis for our stay. Its location is convenient, breakfast was great, and staff were super sweet."
United States
Jasmine
The price is Rp1.740.975
Rp2.123.971 total
includes taxes & fees
24 Sept - 25 Sept
Hotel Genessis
A cozy room with a round table, striped armchairs, and a potted plant.

10. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,009 reviews)
"Very clean room staff was very helpful with accommodations and I would come back again"
United States
Simon
The price is Rp3.373.083
Rp4.561.336 total
includes taxes & fees
27 Sept - 28 Sept
Hotel Camino Real Antigua
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

11. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,157 reviews)
"Outstanding staff and the hotel was beautiful"
United States
Mario
The price is Rp4.247.586
Rp5.399.788 total
includes taxes & fees
27 Sept - 28 Sept
Hotel Museo Spa Casa Santo Domingo
A covered corridor with tiled flooring, potted plants, and a wooden bench.

12. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (804 reviews)
"Very nice hotel!"
United States
Katie
The price is Rp1.609.560
Rp1.963.663 total
includes taxes & fees
29 Sept - 30 Sept
Hotel Las Farolas
A pool area with a stone archway, a small waterfall, and a view of a building with a balcony.

13. Hotel Posada del Angel

Hotel Posada del Angel
4.0 star property
1 km from Santa Ana
9.6 out of 10, Exceptional, (318 reviews)
"Friendly staff, nice breakfast downstairs or on the rooftop, comfortable and relaxing stay."
United States
Michael
The price is Rp3.485.519
Rp4.252.333 total
includes taxes & fees
26 Sept - 27 Sept
Hotel Posada del Angel
A corner with two upholstered chairs, a small round table, and a potted plant.

14. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (458 reviews)
"Excellent location. Staff friendly and helpful."
United States
Martin
The price is Rp1.518.898
Rp1.853.056 total
includes taxes & fees
24 Sept - 25 Sept
Ciel-Luxe Hotels
An outdoor patio with stone flooring, wicker furniture, and umbrellas providing shade.

15. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (368 reviews)
"Great location, very friendly staff and very clean."
United States
Martha
The price is Rp732.350
Rp893.467 total
includes taxes & fees
28 Sept - 29 Sept
Hotel Casa Carmina by AHS
A building with a covered patio area, a garden with various plants, and a hanging vine with purple flowers.

16. Hotel Aurora

Hotel Aurora
3.5 star property
Historic Center, 1.1 km from Santa Ana
9.6 out of 10, Exceptional, (425 reviews)
"Location was about as perfect as can be, nice size room and staff was very helpful for restaurants, things to do, travel related stuff, highly recommend"
United States
Paul
The price is Rp1.335.178
Rp1.628.917 total
includes taxes & fees
27 Sept - 28 Sept
Hotel Aurora
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

17. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (275 reviews)
"Excellent location, delicious breakfast, nice garden, friendly staff."
United States
Liang
The price is Rp3.212.460
Rp3.919.201 total
includes taxes & fees
30 Sept - 1 Oct
Las Cruces Boutique Hotel
A multi-level outdoor garden with potted plants and a wooden pergola structure.

18. Naif Boutique Hotel

Naif Boutique Hotel
3.0 star property
Historic Center, 1.4 km from Santa Ana
9.0 out of 10, Wonderful, (495 reviews)
"Great Service and breakfasts …"
United States
GIOVANNI
The price is Rp1.415.014
Rp1.726.317 total
includes taxes & fees
24 Sept - 25 Sept
Naif Boutique Hotel
A corridor with tiled flooring, wooden benches, and potted plants.

19. Hotel Meson del Valle by AHS

Hotel Meson del Valle by AHS
3.0 star property
1.2 km from Santa Ana
8.6 out of 10, Excellent, (541 reviews)
"The staff was very helpful, the trim was cleaned and the location very convenient."
United States
JUANCARLO
The price is Rp713.166
Rp870.063 total
includes taxes & fees
24 Sept - 25 Sept
Hotel Meson del Valle by AHS
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

20. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (932 reviews)
"Beautiful hotel and great stay."
United States
Judy
The price is Rp4.292.160
Rp5.504.695 total
includes taxes & fees
24 Sept - 25 Sept
El Convento Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

10/10 Excellent
"Everything was excellent. Housekeeping, Breakfast staff, Bar Staff, Reception.......all of them."
Elvin Anthony 5-night trip
Posted 15 hours ago
Wyndham Garden Guatemala City

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favourite place to stay in Santa Ana?
Based on our traveller data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.