Santo Spirito Travel Guide

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A town square with historic buildings, a church, and a bell tower.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art galleries and notable monuments in this vibrant area.
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Things to do

Florence Accademia Gallery Tour with Entrance Ticket Included

Florence Accademia Gallery Tour with Entrance Ticket Included

Rp890.679
per adult
92% of travellers recommend
Florence Accademia Gallery Tour with Entrance Ticket Included
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

Tuscany Experience In Pisa, Siena, San Gimignano & Chianti

Rp1.139.121
per adult
92% of travellers recommend
Tuscany Experience In Pisa, Siena, San Gimignano & Chianti
Best of Florence Tour with Fast Track Accademia & Duomo

Best of Florence Tour with David at Accademia & Duomo (with VIP option)

Rp1.298.907
per adult
96% of travellers recommend
Best of Florence Tour with David at Accademia & Duomo (with VIP option)
Florence David Tour: Michelangelo, Donatello & 48h Art Pass

Florence David Tour: Michelangelo, Donatello & 48h Art Pass

Rp1.422.612
per adult
Florence David Tour: Michelangelo, Donatello & 48h Art Pass
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

Rp2.412.256
per adult
100% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
Skip the line ticket & Audio guide to Brunelleschi's Dome

Reserved Entry Ticket & Audio guide to Brunelleschi's Dome

Rp1.216.437
per adult
Reserved Entry Ticket & Audio guide to Brunelleschi's Dome
See all activities in Florence

Top hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
The price is Rp3.214.467 per night from 31 Aug to 1 Sept
Rp3.214.467
Rp3.826.218 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free Wi-Fi and room service. Our guests praise the breakfast and the helpful staff in their reviews. Popular ...
9.8/10 Exceptional! (713 reviews)
"Good location, close to main attractions."

Reviewed on 21 Aug 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
The price is Rp1.776.459 per night from 31 Aug to 1 Sept
Rp1.776.459
Rp2.243.391 total
31 Aug - 1 Sept
includes taxes & fees
Stay at this residence in Florence. Enjoy free Wi-Fi, valet parking (surcharge) and daily housekeeping. Popular attractions Ponte Vecchio and Piazza del Duomo ...
9.2/10 Wonderful! (296 reviews)
"The location and staff is amazing! The room was huge, great AC!!"

Reviewed on 22 Aug 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
The price is Rp1.521.571 per night from 30 Aug to 31 Aug
Rp1.521.571
Rp1.963.014 total
30 Aug - 31 Aug
includes taxes & fees
Stay at this boutique hotel in Florence. Enjoy free Wi-Fi, breakfast (surcharge) and room service. Our guests praise the helpful staff in their reviews. Popular ...
8.4/10 Very good! (1,006 reviews)
"Very clean, nice rooms, staff and great breakfast / evening food in the restaurant. Location 20min walk to main Santa Maria Station."

Reviewed on 16 Aug 2026

UNA Hotels Vittoria Firenze
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Via dei Serragli 49 Florence FI
The price is Rp2.036.898 per night from 7 Sept to 8 Sept
Rp2.036.898
Rp2.488.548 total
7 Sept - 8 Sept
includes taxes & fees
Stay at this guesthouse in Florence. Enjoy free Wi-Fi, 2 meeting rooms and satellite TV channels. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (235 reviews)
"There was a fridge and AC in the room which was nice. Check-in desk was friendly, we actually checked in like an hour early and when checking out we checked out 15 minutes late, not charged and were able to drop our bags with a bathroom available in the lobby. The area felt safe at night and there ..."

Reviewed on 14 Aug 2026

Foresteria Valdese di Firenze - Casa per Ferie
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is Rp2.181.533 per night from 24 Aug to 25 Aug
Rp2.181.533
Rp2.688.973 total
24 Aug - 25 Aug
includes taxes & fees
Stay at this residence in Florence. Enjoy free Wi-Fi, concierge services and premium bedding. Our guests praise the helpful staff in their reviews. Popular attractions ...
Palazzo Mannaioni Suites
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
Stay at this hostel in Florence. Enjoy free Wi-Fi, daily housekeeping and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Cathedral of ...
7.8/10 Good! (64 reviews)
"No"

Reviewed on 30 Jul 2026

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Hostel Santa Monaca
See all 500 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas for the activities you enjoy most.
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Piazza del Duomo or Piazza di Santa Maria Novella while you're exploring the neighbourhood.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Santa Croce is known for its interesting museums, and you can plan a trip to Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito Travel Guide